The role of public relations strategies and tactics in building symmetric donor relationships

This study researched relationships between nonprofit organizations and their donors. The researcher looked into the different public relations strategies and tactics that nonprofits use to build and maintain relationships with their donors, and then examined the effectiveness of those strategies and tactics. The study required a content analysis of nonprofit websites to determine the strategies and tactics that nonprofit organizations use to build relationships with their donors. It also included a focus panel of nonprofit donors who discussed which strategies and tactics donors need to establish and maintain and mutually beneficial relationship with a nonprofit organization and which strategies and tactics donors feel are ineffective at creating relationships. The study supported the hypothesis that certain public relations strategies and tactics cause beneficial donor relations particularly among donors considering lapsing. The study also found that the strategies and tactics that best fulfill donor needs either do not appear or lack salience on nonprofit websites

Aseptic Machining of Live Bendable Osteochondral Allografts for Articular Surface Remodeling

Young patients diagnosed with post-traumatic osteoarthritis (PTOA) face significant hurdles to restoring pain-free joint function. While surgical interventions exist for replacing damaged cartilage, few are able to offer complete replacement of the articular surface with a bearing material that maintains the longevity and mechanical properties of native articular cartilage necessary to prevent the need for costly and painful revision procedures. Osteochondral allograft technology has begun to address this need by allowing surgeons to resurface constrained small to medium articular defects with live tissue-bank-sourced cartilage tissue explants. A primary limitation surgeons face when choosing osteochondral allotransplantation to treat large articular surface deficits is the scarcity of high-quality live explant tissue with sufficient congruence to fully restore the biomechanical function in the affected joint. This dissertation asserts that augmentation of native tissues donated to tissue banks is a promising strategy for providing more physiologically appropriate tissue replacements for patients with PTOA, providing significant symptomatic relief and allowing young patients to delay or prevent invasive total joint arthroplasty treatments.This dissertation aims to improve treatment modalities for this patient population by developing a surgical technique that enables adaptive reshaping of the articular surface of donor osteochondral tissue explants. The driving hypothesis of this dissertation is that osteochondral allografts that conform better to the opposing articular surface result in better clinical outcomes than those with lesser congruence with the native joint. The corollary hypothesis is that better conformity may be achieved by providing some measure of bending flexibility to the allograft, using streamlined tissue processing procedures to cut grooves in the bony substrate. To address these needs, we first developed, implemented, and validated the technology for milling grooves on the back of large human and canine osteochondral allografts. This resulted in the development of a process for milling grooves in patellar osteochondral samples using a computer-numerically controlled 3-axis milling machine. Sample-specific spatial information was captured within machining fixtures to generate machining paths. The curvature of human and canine osteochondral allografts was captured using a laser scanning system to fit B-Spline surfaces and generate articular curvature maps for the modified allografts. We hypothesize that due to the surface modification enabled by the bending method, bendable osteochondral allografts may provide better curvature matching for patella transplants in the patellofemoral joint. We used a cadaveric knee joint model to investigate patellofemoral joint congruence for unbent and bendable osteochondral allografts at various flexion angles. Shell and bendable allografts were machined from donor human patellae and inserted into the patellofemoral joint space of five knee joints, creating 25 femur-patella osteochondral allograft pairings. Patellofemoral joints with either shell or bendable allografts were loaded at 15-degree increments from 15 to 90 degrees flexion, and the resultant patellofemoral joint contact area was measured and compared against the native patellofemoral contact areas. On average, no significant difference in contact area was found between native patellofemoral joints and OCAs or BOCAs, indicating that both types of allografts restored native congruence. This result aligned with prior computational models of the behavior of bendable and shell allografts in the patellofemoral joint. This finding suggests that future investigations of the benefits of BOCA for allografting other joints could be initiated using computational methods, as the results of the current study suggest that the computational predictions may remain valid under the right set of conditions. Clinical studies of outcomes of osteochondral tissue transplantation indicate that maintenance of donor chondrocyte viability is crucial for the long-term success of the transplanted tissue. In order to assure that CNC machined allografts maintained appropriate chondrocyte viability and tissue sterility, we created a sterile environment for CNC milling of fresh canine patellar osteochondral allografts and quantified allograft chondrocyte viability for up to two weeks post-milling. Following machining and extended culture, bending of the allografts produced neither fracture of the samples nor resulted in loss of chondrocyte viability when compared to non-grooved controls. Therefore, these results provide basic scientific support for the clinical use of bendable osteochondral allografts. Having developed a method of bendable allografts and verifying the tissue viability and sterility, in addition to simulating joint contact in the cadaveric model, we ran a study to assess the performance of bendable osteochondral allografts and shell allografts in the contralateral stifle joints of purpose-bred dogs. This animal model was used to measure the clinical outcomes of bendable osteochondral allografts transplantation following in-vivo loading. Functional clinical outcomes were collected, including force mat kinematics, lameness scoring, range of motion, and pain scoring. At the termination of the study, allograft tissue and synovial fluid from the joint were recovered to assess the sterility, chondrocyte viability, chondrocyte morphology, and bony integration of the allograft. The allografts showed no signs of infection or rejection, and the CNC-machined shell allografts performed well in the joint. Unfortunately, the grooves machined for the bendable allograft patellae were more appropriate in width for the human patella. The removal of excess bony tissue destabilized the bendable allografts and led to fractures and fissures in the tissue. Based on the fissuring and fragmentation mode of failure noted in the canine BOCAs, the size and number of the machined grooves must be optimized for preclinical testing so the potential advantages of bendable OCAs can be realized without compromising their integrity and osteointegration during healing. Bulk mechanical properties and failure thresholds dependent on the width of allograft grooves must be established to reduce the risk of post-transplantation failure. Ongoing work aims to establish safe geometrically-based machining criteria and determine load-to-failure thresholds for osteochondral allografts to improve tissue integrity and functional viability post-transplantation. This aim will be addressed by loading canine bendable allografts with variable groove widths to assess the threshold for mechanical failure against simulated femoral trochlea. The aim of this study is to define allograft bulk mechanical properties and failure thresholds for producing bendable osteochondral allografts. The final chapter of this dissertation aims to assess the impact of sustained mechanical loading on the fluid exchange between the interfibrillar and extrafibrillar space in native articular cartilage, as the fluid load support in articular cartilage is crucial to the maintenance of the low coefficient of friction within the tissue. In our study, we developed a technique to measure water extruded from the interfibrillar space in articular cartilage by applying static compression to unconfined tissue. Preliminary results indicate that the loading and pressurization of the articular tissue can potentially make previously trapped interfibrillar water content more accessibl

O assédio moral organizacional à luz da psicodinâmica do trabalho

Resumo: Através dessa monografia pretendemos discutir a questão do assédio moral organizacional como prática sistemática da organização do trabalho, violência que decorre do poder diretivo do empregador, expresso na forma jurídica do jus variandi. Mostramos como o abuso desse poder deverá ser limitado pelos direitos fundamentais, especialmente pela dignidade da pessoa humana. Para tanto, traçamos um histórico da violência moral no ambiente de trabalho, e de seu combate através das reinvindicações trabalhistas. Na sequência, a partir da ótica da psicodinâmica do trabalho, objetivamos compreender como as empresas exploram o sofrimento do trabalhador como meio de atingir seus interesses, especialmente o de aumento da produtividade, bem como buscamos apresentar o conceito de assédio moral organizacional utilizado pela doutrina e suas diferenças com o assédio moral interpessoal. Por fim, através da casuística jurídica, discutimos duas possibilidades de posicionamentos em relação aos casos de assédio moral organizaciona

Avaliação metabólica e síndrome metabólica em pacientes HIV positivo atendidos no ambulatório municipal de DST/HIV/AIDS do município de Maringá

Orientador: Prof.ª Dr.ª Márcia Regina BatistaDissertação (mestrado em Biociências Aplicadas à Farmácia) - Universidade Estadual de Maringá, 2011RESUMO: Problemas cardiovasculares são as principais causas de óbito nos países desenvolvidos. Tem se notado ao longo dos anos um aumento progressivo da mortalidade de pacientes HIV positivo devido a problemas de ordem cardiovascular. Alterações metabólicas e síndrome metabólica aumentam o risco de problemas cardíacos e são freqüentemente associadas ao uso de terapia antiretroviral. Portanto, buscamos avaliar a presença e evolução da síndrome metabólica em pacientes HIV positivo usuários de antiretrovirais. Este é um estudolongitudinal, retrospectivo e prospectivo avaliando parâmetros propostos pelo NCEP-ATPIII além de peso e colesterol total. As avaliações ocorrem em 2 fases distintas, com um intervalo de 6 ±1mês das coletas. Dentre os 45 pacientes analisados 15,5% apresentaram síndrome metabólica na 1ª fase do estudo e 26,7% na 2ª fase (p = 0,004). Valores diminuídos de HDL foram identificados em 53,3% dos pacientes em ambas as fases, e valores aumentados de triglicerídeos em 42,2% dos pacientes na 1ª fase e 51,1% na 2ª fase. Dois dos pacientes (4,44%) foram capazes de reverter o quadro de síndrome metabólica. Foi possível caracterizar a síndrome metabólica e observar o aumento de intensidade e do número de indivíduos acometidos por alterações metabólicas entre os pacientes acompanhados. Alguns pacientes foram capazes de reverter essa tendência, possivelmente devido a alterações de hábitos de vidaABSTRACT: Cardiovascular diseases are the main cause o death in developed countries. It’s been noticed through the years a progressive increase in HIV positive patients mortality due cardiovascular problems. Metabolic alterations and metabolic syndrome increase the risk of cardiac problems and are frequently associated with the use of antiretroviral therapy. Therefore we seek to evaluate the presence and evolution of metabolic syndrome in HIV positive patients. This is a longitudinal, retrospective and prospective study that evaluating NCEP-ATPIII proposed parameters besides weight and total cholesterol. The evaluations occurred in 2 distinctive phases, with a 6 ±1month period between the collect of data. Amongst the 45 analyzed patients 15% showed metabolic syndrome in the first study phase and 26,7 in the second phase (p = 0,004). Diminished HDL levels were identified in 53,3% of the patients in both phases, increased levels of triglycerides in 42,2% of the patients in the first phase and 51,1 in the second first. Two of the patients (4,44%) were able to revert the metabolic syndrome characterization. It was possible to identify the metabolic syndrome and to observe its increase in intensity and in number of patients subject to metabolic alterations amongst the followed patients. A few of the patients were able to revert this tendency, possibly duo to changes in lifestyle44 f. : il

Para-péri scolaire : on y mange, on y joue, mais encore ?

L’école est un bastion, légitimée par tous et toutes, installée dans ses murs, appuyée sur ses certitudes républicaines. Et pourtant ce n’est qu’une maison dans la ville, fréquentée par tant de diversité qu’elle en a perdu son latin. Même chargée de violence symbolique, elle est avant tout ce qu’en font les élèves et les profs. On y pleure et on y rit comme dans la vraie vie. Autour ou à côté, il y a ces drôles d’institutions qui s’occupent des enfants qui quittent la forteresse scolaire à heures fixes. Ces institutions proches n’ont pas la même stature, les professionnel×le×s qui y travaillent n’ont pas la même réputation. Ce qu’ils/elles dispensent ne serait donc pas de l’éducation ? Faut-il continuer à creuser le fossé qui séparerait enseigner et éduquer