Mental health and developmental disorders in infancy and early childhood. The PDM-2

We provide a general introduction to the theoretical and empirical sources informing the development of the Infancy and Early Childhood Section (IEC) of the second edition of the Psychodynamic Diagnostic Manual (PDM-2). We offer a brief exploration of the evolution of developmental psychoanalysis and its applications to infant mental health, along with an example of applying the IEC framework to clinical and developmental data from a longitudinal study based on developmental and psychodynamic principles. This article illustrates the evolution of theory in the context of interdisciplinary integration and explores its implications for diagnosis and clinical formulatio

Zinc transporter 8 and MAP3865c homologous epitopes are recognized at T1D onset in Sardinian children

Our group has recently demonstrated that Mycobacterium avium subspecies paratuberculosis (MAP) infection significantly associates with T1D in Sardinian adult patients. Due to the potential role played by MAP in T1D pathogenesis, it is relevant to better characterize the prevalence of anti-MAP antibodies (Abs) in the Sardinian population, studying newly diagnosed T1D children. Therefore, we investigated the seroreactivity against epitopes derived from the ZnT8 autoantigen involved in children at T1D onset and their homologous sequences of the MAP3865c protein. Moreover, sera from all individuals were tested for the presence of Abs against: the corresponding ZnT8 C-terminal region, the MAP specific protein MptD, the T1D autoantigen GAD65 and the T1D unrelated Acetylcholine Receptor. The novel MAP3865c281–287 epitope emerges here as the major C-terminal epitope recognized. Intriguingly ZnT8186–194 immunodominant peptide was cross-reactive with the homologous sequences MAP3865c133–141, strengthening the hypothesis that MAP could be an environmental trigger of T1D through a molecular mimicry mechanism. All eight epitopes were recognized by circulating Abs in T1D children in comparison to healthy controls, suggesting that these Abs could be biomarkers of T1D. It would be relevant to investigate larger cohorts of children, followed over time, to elucidate whether Ab titers against these MAP/Znt8 epitopes wane after diagnosis

The Vehicle Routing Problem with Divisible Deliveries and Pickups

The vehicle routing problem with divisible deliveries and pickups is a new and interesting model within reverse logistics. Each customer may have a pickup and delivery demand that have to be served with capacitated vehicles. The pickup and the delivery quantities may be served, if beneficial, in two separate visits. The model is placed in the context of other delivery and pickup problems and formulated as a mixed-integer linear programming problem. In this paper, we study the savings that can be achieved by allowing the pickup and delivery quantities to be served separately with respect to the case where the quantities have to be served simultaneously. Both exact and heuristic results are analysed in depth for a better understanding of the problem structure and an average estimation of the savings due to the possibility of serving pickup and delivery quantities separately

Does the Danube exist? Versions of reality given by various regional climate models and climatological datasets

We present an intercomparison and verification analysis of several regional climate models (RCMs) nested into the same run of the same Atmospheric Global Circulation Model (AGCM) regarding their representation of the statistical properties of the hydrological balance of the Danube river basin for 1961-1990. We also consider the datasets produced by the driving AGCM, from the ECMWF and NCEP-NCAR reanalyses. The hydrological balance is computed by integrating the precipitation and evaporation fields over the area of interest. Large discrepancies exist among RCMs for the monthly climatology as well as for the mean and variability of the annual balances, and only few datasets are consistent with the observed discharge values of the Danube at its Delta, even if the driving AGCM provides itself an excellent estimate. Since the considered approach relies on the mass conservation principle and bypasses the details of the air-land interface modeling, we propose that the atmospheric components of RCMs still face difficulties in representing the water balance even on a relatively large scale. Their reliability on smaller river basins may be even more problematic. Moreover, since for some models the hydrological balance estimates obtained with the runoff fields do not agree with those obtained via precipitation and evaporation, some deficiencies of the land models are also apparent. NCEP-NCAR and ERA-40 reanalyses result to be largely inadequate for representing the hydrology of the Danube river basin, both for the reconstruction of the long-term averages and of the seasonal cycle, and cannot in any sense be used as verification. We suggest that these results should be carefully considered in the perspective of auditing climate models and assessing their ability to simulate future climate changes.Comment: 25 pages 8 figures, 5 table

Repositório de Recursos de Informação da Rede de Agricultura de Precisão da Embrapa (Rede AP): manual do usuário: Versão 1.0.

Perfis de Acesso e Administração. Acesso ao Repositório. Repositório de Dados. Visualizar Dados Georreferenciados. Catalogação de Metadados

Baroclinic instability of a symmetric, rotating, stratified flow: a study of the nonlinear stabilisation mechanisms in the presence of viscosity

This paper presents the analysis of symmetric circulations of a rotating baroclinic flow, forced by a steady thermal wind and dissipated by Laplacian friction. The analysis is performed with numerical time-integration. Symmetric flows, vertically bound by horizontal walls and subject to either periodic or vertical wall lateral boundary conditions, are investigated in the region of parameter-space where unstable small amplitude modes evolve into stable stationary nonlinear solutions. The distribution of solutions in parameter-space is analysed up to the threshold of chaotic behaviour and the physical nature of the nonlinear interaction operating on the finite amplitude unstable modes is investigated. In particular, analysis of time-dependent energy-conversions allows understanding of the physical mechanisms operating from the initial phase of linear instability to the finite amplitude stable state. Vertical shear of the basic flow is shown to play a direct role in injecting energy into symmetric flow since the stage of linear growth. Dissipation proves essential not only in limiting the energy of linearly unstable modes, but also in selecting their dominant space-scales in the finite amplitude stage

Ferramenta para integração de dados de recursos naturais dos biomas brasileiros.

O projeto NATDATA, sigla para Plataforma de Integração de Dados dos Recursos Naturais (MACÁRIO et al., 2011) tem como um de seus objetivos criar uma interface para o usuário final das informações sobre os recursos naturais dos biomas brasileiros, ajudando-o com um ambiente intuitivo que permita a consulta rápida e integrada a esses dados. Essa consulta permitirá que haja uma melhor orientação dos investimentos, como uma visão antecipada dos possíveis problemas que alguma região possa sofrer. Devido ao modo heterogêneo com que diversas instituições brasileiras colheram essas informações, há uma grande dificuldade em reaproveitá-las em conjunto. Com isso, o projeto NATDATA foca centralizar essa informação, tornando-a utilizável

Geração de mapas georreferenciados para visualização de dados de campo para auxílio na tomada de decisão em irrigação de precisão.

Este trabalho teve como objetivo desenvolver um aplicativo computacional capaz de gerar mapas georreferenciados úteis para a tomada de decisão em irrigação de precisão. Para tanto, foram utilizadas as bibliotecas TerraLib e SOMCode, ambas de código aberto e escritas na linguagem C++, desenvolvidas pelo Instituto Nacional de Pesquisas Espaciais (INPE) e pela Embrapa Tabuleiros Costeiros (CPATC), respectivamente. Os dados utilizados para a geração desses mapas foram obtidos por uma grade de sensores de uma unidade piloto da plataforma Irrigap, desenvolvida pela Embrapa Instrumentação Agropecuária (CNPDIA), dados esses referentes a medidas horárias de umidade e temperatura do solo e temperatura do ar. Diferentes métodos de interpolação foram utilizados, com o intuito de verificar qual a melhor maneira de se gerar mapas que possibilitem a visualização de áreas com o mesmo comportamento com relação às variáveis de solo e climatológicas, as chamadas zonas de manejo agrícolas. Os resultados obtidos mostraram que é possível a identificação dessas zonas, desde que sejam utilizados os algoritmos corretos para cada situação. Além disso, aplicativos para a geração de mapas temáticos utilizando dados reais podem se tornar importantes para a tomada de decisão em agricultura de precisão, proporcionando benefícios como a economia de água e energia durante o período de irrigação