Evidence of late Quaternary environmental change in a continental east Antarctic lake from lacustrine sedimentary pigment distributions

A sediment core from Progress Lake, one of the oldest lacustrine sequences in East Antarctica, contains distinct zones dating from a previous interglacial (most likely Marine Isotope Stage 5e, c. 125-115 kyr BP) and the present interglacial (Marine Isotope Stage 1), separated by a transition zone representing when the lake became sub-glacial. Profiles of fossil pigments, determined using high performance liquid chromatography and liquid chromatography-tandem mass spectrometry, show distinct differences in the photoautotrophic community during these two interglacial periods. The first was dominated by algae and purple phototrophic bacteria, with periods of photic zone euxinia indicated by pigments from anoxygenic phototrophic bacteria. Specific chlorophyll a derivatives reveal periods when grazing pressure impacted significantly on the phytoplankton community. The virtual absence of pigments in the transition zone reflects severe restriction of photoautotrophic activity, consistent with the take having become sub-glacial. Retreat of snow and ice in the late Holocene (3345 C-14 yr Bp) allowed establishment of a less diverse primary producer community, restricted to algae and cyanobacteria. Grazers were severely restricted and oxidative transformation was more important than during the previous interglacial. The pigment data provide a unique and detailed insight in to the evolution of the lake ecology over an interglacial-glacial-interglacial transition and strong evidence that the Marine Isotope Stage 5e interglacial in this region of coastal East Antarctica was several degrees warmer than at present

Searching the World-Wide-Web using nucleotide and peptide sequences

*Background:* No approaches have yet been developed to allow instant searching of the World-Wide-Web by just entering a string of sequence data. Though general search engines can be tuned to accept ‘processed’ queries, the burden of preparing such ‘search strings’ simply defeats the purpose of quickly locating highly relevant information. Unlike ‘sequence similarity’ searches that employ dedicated algorithms (like BLAST) to compare an input sequence from defined databases, a direct ‘sequence based’ search simply locates quick and relevant information about a blunt piece of nucleotide or peptide sequence. This approach is particularly invaluable to all biomedical researchers who would often like to enter a sequence and quickly locate any pertinent information before proceeding to carry out detailed sequence alignment. 

*Results:* Here, we describe the theory and implementation of a web-based front-end for a search engine, like Google, which accepts sequence fragments and interactively retrieves a collection of highly relevant links and documents, in real-time. e.g. flat files like patent records, privately hosted sequence documents and regular databases. 

*Conclusions:* The importance of this simple yet highly relevant tool will be evident when with a little bit of tweaking, the tool can be engineered to carry out searches on all kinds of hosted documents in the World-Wide-Web.

*Availability:* Instaseq is free web based service that can be accessed by visiting the following hyperlink on the WWW
http://instaseq.georgetown.edu 
&#xa

System size dependence of strangeness production at 158 AGeV

Strange particle production in A+A interactions at 158 AGeV is studied by the CERN experiment NA49 as a function of system size and collision geometry. Yields of charged kaons, phi and Lambda are measured and compared to those of pions in central C+C, Si+Si and centrality-selected Pb+Pb reactions. An overall increase of relative strangeness production with the size of the system is observed which does not scale with the number of participants. Arguing that rescattering of secondaries plays a minor role in small systems the observed strangeness enhancement can be related to the space-time density of the primary nucleon-nucleon collisions.Comment: 5 pages, 3 figures, Presented at Quark Matter 2002, Nantes, Franc

Polymicrogyria: pathology, fetal origins and mechanisms

Polymicrogyria (PMG) is a complex cortical malformation which has so far defied any mechanistic or genetic explanation. Adopting a broad definition of an abnormally folded or festooned cerebral cortical neuronal ribbon, this review addresses the literature on PMG and the mechanisms of its development, as derived from the neuropathological study of many cases of human PMG, a large proportion in fetal life. This reveals the several processes which appear to be involved in the early stages of formation of polymicrogyric cortex. The most consistent feature of developing PMG is disruption of the brain surface with pial defects, over-migration of cells, thickening and reduplication of the pial collagen layers and increased leptomeningeal vascularity. Evidence from animal models is consistent with our observations and supports the notion that disturbance in the formation of the leptomeninges or loss of their normal signalling functions are potent contributors to cortical malformation. Other mechanisms which may lead to PMG include premature folding of the neuronal band, abnormal fusion of adjacent gyri and laminar necrosis of the developing cortex. The observation of PMG in association with other and better understood forms of brain malformation, such as cobblestone cortex, suggests mechanistic pathways for some forms of PMG. The role of altered physical properties of the thickened leptomeninges in exerting mechanical constraints on the developing cortex is also considered. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40478-014-0080-3) contains supplementary material, which is available to authorized users

Elementary Hadronic Interactions at the CERN SPS

New data from the NA49 experiment at the CERN SPS concerning hadron+proton and hadron+nucleus interactions are discussed and compared to nucleus+nucleus collisions. Detailed information on baryonic momentum distributions and nuclear enhancement factors for kaons and cascade baryons are extracted.Comment: 11 pages, 9 figures, to be published in the Proceedings of the XVIth International Conference on Ultrarelativistic Nucleus-Nucleus Collisions "Quark Matter 2002", Nantes, France, July 200

Baryon and antibaryon production in hadron-hadron and hadron-nucleus interactions

Cascade baryon and anti-baryon yields have been measured in p+p and p+A collisions. After extraction of the projectile component in p+A interactions close similarities with A+A collisions concerning the nuclear enhancement factors are observed. In addition the importance of effects related to projectile isospin and to net baryon stopping is pointed out.Comment: 4 pages, 5 figures, Presented at Quark Matter 2002, Nantes, Franc

Q-Value for the Fermi Beta-Decay of 46V

By comparing the Q-values for the 46Ti(3He,t)46V and 47Ti(3He,t)47}V reactions to the isobaric analog states the Q-value for the superallowed Fermi-decay of 46V has been determined as Q_{EC}(46V)=(7052.11+/-0.27) keV. The result is compatible with the values from two recent direct mass measurements but is at variance with the previously most precise reaction Q-value. As additional input quantity we have determined the neutron separation energy S_n(47Ti)=(8880.51+/-0.25) keV

A convenient category of locally preordered spaces

As a practical foundation for a homotopy theory of abstract spacetime, we extend a category of certain compact partially ordered spaces to a convenient category of locally preordered spaces. In particular, we show that our new category is Cartesian closed and that the forgetful functor to the category of compactly generated spaces creates all limits and colimits.Comment: 26 pages, 0 figures, partially presented at GETCO 2005; changes: claim of Prop. 5.11 weakened to finite case and proof changed due to problems with proof of Lemma 3.26, now removed; Eg. 2.7, statement before Lem. 2.11, typos, and other minor problems corrected throughout; extensive rewording; proof of Lem. 3.31, now 3.30, adde

Temporary brittle bone disease:association with intracranial bleeding

Abstract We report 20 infants aged between 1 month and 6 months found to have subdural bleeding and also multiple unexplained fractures in a pattern similar to that described earlier as temporary brittle bone disease. Child abuse seemed unlikely as a cause of the fractures as in no case was there clinical evidence of injury commensurate with the fracturing, as some patients had fractures while in hospital and as metaphyseal lesions, when present, were often symmetrical in distribution. Abuse seemed unlikely to have been the cause of the subdural bleeding in several patients; three had clear histories of accidental injury and five had evidence that the initial bleeding was likely to have taken place at birth. Abuse also seemed unlikely as the cause of the syndrome; the nine patients who were returned to their parents had no subsequent allegations of abuse with a mean follow-up period of 15.8 years. The finding of hypermobile joints in the parents of eight of the children is an additional pointer to a natural cause for this condition. The cause of this combination of fractures and subdural bleeding is not yet clear but it is important to be aware that it can result from natural disease

Earth‐Moon‐Mars Radiation Environment Module framework

[1] We are preparing to return humans to the Moon and setting the stage for exploration to Mars and beyond. However, it is unclear if long missions outside of low-Earth orbit can be accomplished with acceptable risk. The central objective of a new modeling project, the Earth-Moon-Mars Radiation Exposure Module (EMMREM), is to develop and validate a numerical module for characterizing time-dependent radiation exposure in the Earth-Moon-Mars and interplanetary space environments. EMMREM is being designed for broad use by researchers to predict radiation exposure by integrating over almost any incident particle distribution from interplanetary space. We detail here the overall structure of the EMMREM module and study the dose histories of the 2003 Halloween storm event and a June 2004 event. We show both the event histories measured at 1 AU and the evolution of these events at observer locations beyond 1 AU. The results are compared to observations at Ulysses. The model allows us to predict how the radiation environment evolves with radial distance from the Sun. The model comparison also suggests areas in which our understanding of the physics of particle propagation and energization needs to be improved to better forecast the radiation environment. Thus, we introduce the suite of EMMREM tools, which will be used to improve risk assessment models so that future human exploration missions can be adequately planned for