Assay for free secretory component and methods for monitoring organ rejection

Methods of monitoring and detecting the early onset of organ injury incident rejection of a organ rejection in an animal are disclosed. The described methods are capable of distinguishing organ rejection injury from other organ tissue damage in the animal. Free secretory component levels in an animal biological fluid (e.g., bile, urine, blood, amniotic fluid) may be used to identify organ rejection in an animal. Multiple and single organ transplant patients may be monitored and diagnosed according to the claimed methods. Biological fluids, such as blood, (serum) or urine, are analyzed immunologically using a particularly adapted ELISA which are then compared to an FSC control concentration to identify elevated FSC values. Animals with test FSC above FSC control concentrations are diagnosed as having an ongoing organ rejection episode. The detection of congenital renal dysfunction in utero is also provided according to the present invention through the measurement of FSC in the amniotic fluid. The described methods are specific for indicating organ rejection tissue injury, and distinguish kidney rejection tissue injury, in particular, from other causes of kidney injury, such as cyclosporin toxicity, urinary tract infection, and urinary obstruction and toxicity (incident to immunosuppressive therapy with cyclosporin). A kit for use in the identification of an organ rejection episode in a patient through measurement of FSC in a biological sample is also provided.Board of Regents, University of Texas Syste

Nonlinear Oscillations and Bifurcations in Silicon Photonic Microresonators

Silicon microdisks are optical resonators that can exhibit surprising nonlinear behavior. We present a new analysis of the dynamics of these resonators, elucidating the mathematical origin of spontaneous oscillations and deriving predictions for observed phenomena such as a frequency comb spectrum with MHz-scale repetition rate. We test predictions through laboratory experiment and numerical simulation.Comment: Main text: 5 pages, 6 figures. Supplemental material: 12 pages, 8 figure

The Mass-Loss Return From Evolved Stars to The Large Magellanic Cloud VI: Luminosities and Mass-Loss Rates on Population Scales

We present results from the first application of the Grid of Red Supergiant and Asymptotic Giant Branch ModelS (GRAMS) model grid to the entire evolved stellar population of the Large Magellanic Cloud (LMC). GRAMS is a pre-computed grid of 80,843 radiative transfer (RT) models of evolved stars and circumstellar dust shells composed of either silicate or carbonaceous dust. We fit GRAMS models to ~30,000 Asymptotic Giant Branch (AGB) and Red Supergiant (RSG) stars in the LMC, using 12 bands of photometry from the optical to the mid-infrared. Our published dataset consists of thousands of evolved stars with individually determined evolutionary parameters such as luminosity and mass-loss rate. The GRAMS grid has a greater than 80% accuracy rate discriminating between Oxygen- and Carbon-rich chemistry. The global dust injection rate to the interstellar medium (ISM) of the LMC from RSGs and AGB stars is on the order of 1.5x10^(-5) solar masses/yr, equivalent to a total mass injection rate (including the gas) into the ISM of ~5x10^(-3) solar masses/yr. Carbon stars inject two and a half times as much dust into the ISM as do O-rich AGB stars, but the same amount of mass. We determine a bolometric correction factor for C-rich AGB stars in the K band as a function of J - K color, BC(K) = -0.40(J-K)^2 + 1.83(J-K) + 1.29. We determine several IR color proxies for the dust mass-loss rate (MLR) from C-rich AGB stars, such as log (MLR) = (-18.90)/((K-[8.0])+3.37)-5.93. We find that a larger fraction of AGB stars exhibiting the `long-secondary period' phenomenon are O-rich than stars dominated by radial pulsations, and AGB stars without detectable mass-loss do not appear on either the first-overtone or fundamental-mode pulsation sequences.Comment: 19 pages, 19 figure

Extraction of carrier lifetime in Ge waveguides using pump probe spectroscopy

Carrier lifetimes in Ge-on-Si waveguides are deduced using time-resolved infrared transmission pump-probe spectroscopy. Dynamics of pump-induced excess carriers generated in waveguides with varying Ge thickness and width is probed using a CW laser. The lifetimes of these excess carriers strongly depend on the thickness and width of the waveguide due to defect assisted surface recombination. Interface recombination velocities of 0.975 x 10(4) cm/s and 1.45 x 10(4) cm/s were extracted for the Ge/Si and the Ge/SiO2 interfaces, respectively. Published by AIP Publishing

Carrier lifetime assessment in integrated Ge waveguide devices

Carrier lifetimes in Ge waveguides on Si are deduced from time-resolved pump-probe spectroscopy. For a 1 pm wide Ge waveguide, a lifetime of 1.6 ns is estimated for a carrier density of around 2 x10(19) cm(-3)

A circular dielectric grating for vertical extraction of single quantum dot emission

We demonstrate a nanostructure composed of partially etched annular trenches in a suspended GaAs membrane, designed for efficient and moderately broadband (approx. 5 nm) emission extraction from single InAs quantum dots. Simulations indicate that a dipole embedded in the nanostructure center radiates upwards into free space with a nearly Gaussian far-field, allowing a collection efficiency > 80 % with a high numerical aperture (NA=0.7) optic, and with 12X Purcell radiative rate enhancement. Fabricated devices exhibit an approx. 10 % photon collection efficiency with a NA=0.42 objective, a 20X improvement over quantum dots in unpatterned GaAs. A fourfold exciton lifetime reduction indicates moderate Purcell enhancement.Comment: (3 pages