The VISTA Orion mini-survey: star formation in the Lynds 1630 North cloud

The Orion cloud complex presents a variety of star formation mechanisms and properties and it is still one of the most intriguing targets for star formation studies. We present VISTA/VIRCAM near-infrared observations of the L1630N star forming region, including the stellar clusters NGC 2068 and NGC 2071, in the Orion molecular cloud B and discuss them in combination with Spitzer data. We select 186 young stellar object (YSO) candidates in the region on the basis of multi-colour criteria, confirm the YSO nature of the majority of them using published spectroscopy from the literature, and use this sample to investigate the overall star formation properties in L1630N. The K-band luminosity function of L1630N is remarkably similar to that of the Trapezium cluster, i.e., it presents a broad peak in the range 0.3-0.7 M$_\odot$ and a fraction of sub-stellar objects of $\sim$20%. The fraction of YSOs still surrounded by disk/envelopes is very high ($\sim$85%) compared to other star forming regions of similar age (1-2 Myr), but includes some uncertain corrections for diskless YSOs. Yet, a possibly high disk fraction together with the fact that 1/3 of the cloud mass has a gas surface density above the threshold for star formation ($\sim$129 M$_\odot$ pc$^{-2}$), points towards a still on-going star formation activity in L1630N. The star formation efficiency (SFE), star formation rate (SFR) and density of star formation of L1630N are within the ranges estimated for galactic star forming regions by the Spitzer "core to disk" and "Gould's Belt" surveys. However, the SFE and SFR are lower than the average value measured in the Orion A cloud and, in particular, lower than that in the southern regions of L1630. This might suggest different star formation mechanisms within the L1630 cloud complex.Comment: 22 pages, 9 figure

The thermal state of molecular clouds in the Galactic Center: evidence for non-photon-driven heating

We used the Atacama Pathfinder Experiment (APEX) 12 m telescope to observe the J_KaKc=3_03-2_02, 3_22-2_21, and 3_21-2_20 transitions of para-H_2CO at 218 GHz simultaneously to determine kinetic temperatures of the dense gas in the central molecular zone (CMZ) of our Galaxy. The map extends over approximately 40 arcmin x 8 arcmin (~100x20 pc^2) along the Galactic plane with a linear resolution of 1.2 pc. The strongest of the three lines, the H_2CO (3_03-2_02) transition, is found to be widespread, and its emission shows a spatial distribution similar to ammonia. The relative abundance of para-H_2CO is 0.5-1.2 10^{-9}, which is consistent with results from lower frequency H_2CO absorption lines. Derived gas kinetic temperatures for individual molecular clouds range from 50 K to values in excess of 100 K. While a systematic trend toward (decreasing) kinetic temperature versus (increasing) angular distance from the Galactic center (GC) is not found, the clouds with highest temperature (T_kin > 100 K) are all located near the nucleus. For the molecular gas outside the dense clouds, the average kinetic temperature is 65+/-10 K. The high temperatures of molecular clouds on large scales in the GC region may be driven by turbulent energy dissipation and/or cosmic-rays instead of photons. Such a non-photon-driven thermal state of the molecular gas provides an excellent template for the more distant vigorous starbursts found in ultraluminous infrared galaxies (ULIRGs).Comment: 23 pages, 11 figures, A&A in pres

Herbig-Haro flows in L1641N

We have used the 2.56m Nordic Optical Telescope (NOT) to observe two deep fields in L1641N, selected on the basis of previous shock studies, using the 2.12 micron transition of H2 (and a Ks filter to sample the continuum) for a total exposure time of 4.6 h (72 min Ks) in the overlapping region. The resulting high-resolution mosaic shows numerous new shocks and resolves many known shocks into multiple components. Using previous observations taken 9 years earlier we calculate a proper motion map and combine this with Spitzer 24 micron observations of the embedded young stars. The combined H2 mosaic shows many new shocks and faint structures in the HH flows. From the proper motion map we find that most HH objects belong to two major bi-polar HH flows, the large-scale roughly North-South oriented flow from central L1641N and a previously unseen HH flow in eastern L1641N. Combining the tangential velocity map with the mid-IR Spitzer images, two very likely outflow sources are found. The outflow source of the eastern flow, L1641N-172, is found to be the currently brightest mid-IR source in L1641N and seem to have brightened considerably during the past 20 years. We make the first detection of this source in the near-IR (Ks) and also find a near-IR reflection nebula pointing at the source, probably the illuminated walls of a cone-shaped cavity cleared out by the eastern lobe of the outflow. Extending a line from the eastern outflow source along the proper motion vector we find that HH 301 and HH 302 (almost 1 pc away) belong to this new HH flow.Comment: 10 pages, 4 figures, Accepted for publication by A &

Teaching Lean Thinking Principles Through Hands-on Simulations

The teaching of Lean Enterprise Thinking in the aerospace context requires that students understand a complex subject—aerospace enterprises and their transformation—in a deep and intuitive way. Without this context, the lessons of the LAI Lean Academy Course® will make little sense. A rich simulation of an enterprise with a structure and problems typical of the US aerospace industry is used as a teaching tool. The simulation allows students to understand Lean Thinking at an intuitive level, and practice lean tools in a realistic setting. The simulation enables a CDIO approach (in this case, Comprehend, Design, Implement and Operate), by having the students take two iterations through a CDIO process to transform the simulated enterprise from an inefficient legacy state to a high performance future state (x3 to x6 production using the same resources). The simulation and its teaching goals are described, with reference to the limited literature on simulations in education. The process used in the simulation is then described in a CDIO context. Finally, the success of the simulation is evaluated using limited quantitative and more extensive qualitative data. It is found that the simulation is a powerful learning tool and a key component of the LAI Lean Academy

Herschel/PACS Imaging of Protostars in the HH 1-2 Outflow Complex

We present 70 and 160 micron Herschel science demonstration images of a field in the Orion A molecular cloud that contains the prototypical Herbig-Haro objects HH 1 and 2, obtained with the Photodetector Array Camera and Spectrometer (PACS). These observations demonstrate Herschel's unprecedented ability to study the rich population of protostars in the Orion molecular clouds at the wavelengths where they emit most of their luminosity. The four protostars previously identified by Spitzer 3.6-40 micron imaging and spectroscopy are detected in the 70 micron band, and three are clearly detected at 160 microns. We measure photometry of the protostars in the PACS bands and assemble their spectral energy distributions (SEDs) from 1 to 870 microns with these data, Spitzer spectra and photometry, 2MASS data, and APEX sub-mm data. The SEDs are fit to models generated with radiative transfer codes. From these fits we can constrain the fundamental properties of the protostars. We find luminosities in the range 12-84 L_sun and envelope densities spanning over two orders of magnitude. This implies that the four protostars have a wide range of envelope infall rates and evolutionary states: two have dense, infalling envelopes, while the other two have only residual envelopes. We also show the highly irregular and filamentary structure of the cold dust and gas surrounding the protostars as traced at 160 microns.Comment: 6 pages, 4 figures, accepted for publication in the A&A Herschel special issu

Polypyrrole grafts with poly[(methyl methacrylate)-CO-(2-(N-pyrrolyl)ethyl methacrylate)]

Cataloged from PDF version of article.Conducting polymer grafts of pyrrole and poly[(methyl methacrylate)-co-(2- (N-pyrrolyl) ethyl methacrylate)] containing 0.7% PEMA units were prepared by potentiostatic anodic polymerization of pyrrole in different electrolytic media. Grafting between copolymer and pyrrole was achieved in media where tetrabutylammonium fluoroborate and sodium perchlorate were used as the supporting electrolytes. Characterizations were made by using IT-IR, DSC, TGA, SEM, CV, and elemental analysis. The conductivities of the resultant polymers seemed to be in the order of pure polypyrrole prepared under the same conditions. Copyright o 1997 Elsevier Scienc

Molecular outflows in the young open cluster IC348

We present a wide-field survey of the young open cluster IC348 for molecular H2 outflows. Outflow activity is only found at its south-western limit, where a new subcluster of embedded sources is in an early phase of its formation. If the IC348 cluster had been built up by such subclusters forming at different times, this could explain the large age-spread that Herbig (1998) found for the IC348 member stars. In addition to several compact groups of H2 knots, our survey reveals a large north-south oriented outflow, and we identify the newly discovered far-infrared and mm-object IC348MMS as its source. New deep images in the 1-0 S(1) line of molecular hydrogen trace the HH211 jet and counterjet as highly-collimated chains of knots, resembling the interferometric CO and SiO jets. This jet system appears rotated counter-clockwise by about 3 degrees with respect to the prominent H2 bow shocks. Furthermore, we resolve HH211-mm as a double point-like source in the mm-continuum.Comment: 10 pages, 9 figures, accepted for publication in Ap

Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells

Metastatic competence of cancer cells is influenced by many factors including metabolic alterations and changes in mitochondrial biogenesis and protein homeostasis. While it is generally accepted that mitochondria play important roles in tumorigenesis, the respective molecular events that regulate aberrant cancer cell proliferation remain to be clarified. Therefore, understanding the mechanisms underlying the role of mitochondria in cancer progression has potential implications in the development of new therapeutic strategies. We show that low expression of mitochondrial quality control protease OMA1 correlates with poor overall survival in breast cancer patients. Silencing OMA1 in vitro in patientderived metastatic breast cancer cells isolated from the metastatic pleural effusion and atypical ductal hyperplasia mammary tumor specimens (21MT-1 and 21PT) enhances the formation of filopodia, increases cell proliferation (Ki67 expression), and induces epithelial-mesenchymal transition (EMT). Mechanistically, loss of OMA1 results in alterations in the mitochondrial protein homeostasis, as reflected by enhanced expression of canonic mitochondrial unfolded protein response genes. These changes significantly increase migratory properties in metastatic breast cancer cells, indicating that OMA1 plays a critical role in suppressing metastatic competence of breast tumors. Interestingly, these results were not observed in OMA1-depleted non-tumorigenic MCF10A mammary epithelial cells. This newly identified reduced activity/levels of OMA1 provides insights into the mechanisms leading to breast cancer development, promoting malignant progression of cancer cells and unfavorable clinical outcomes, which may represent possible prognostic markers and therapeutic targets for breast cancer treatment

HOPS 383: An Outbursting Class 0 Protostar in Orion

We report the dramatic mid-infrared brightening between 2004 and 2006 of HOPS 383, a deeply embedded protostar adjacent to NGC 1977 in Orion. By 2008, the source became a factor of 35 brighter at 24 microns with a brightness increase also apparent at 4.5 microns. The outburst is also detected in the submillimeter by comparing APEX/SABOCA to SCUBA data, and a scattered-light nebula appeared in NEWFIRM K_s imaging. The post-outburst spectral energy distribution indicates a Class 0 source with a dense envelope and a luminosity between 6 and 14 L_sun. Post-outburst time-series mid- and far-infrared photometry shows no long-term fading and variability at the 18% level between 2009 and 2012. HOPS 383 is the first outbursting Class 0 object discovered, pointing to the importance of episodic accretion at early stages in the star formation process. Its dramatic rise and lack of fading over a six-year period hint that it may be similar to FU Ori outbursts, although the luminosity appears to be significantly smaller than the canonical luminosities of such objects.Comment: Accepted by ApJ Letters, 6 pages, 4 figures; v2 has an updated email address for the lead autho