Evolution of Endoscopic Lesions in Steroid-Refractory Acute Severe Ulcerative Colitis Responding to Infliximab or Cyclosporine

BACKGROUND/AIMS: Few data on the evolution of endoscopic findings are available in patients with acute severe ulcerative colitis (ASUC). The aim of this study was to describe this evolution in a prospective cohort. METHODS: Patients admitted for a steroid-refractory ASUC and included in a randomized trial comparing infliximab and cyclosporine were eligible if they achieved steroid-free clinical remission at day 98. Flexible sigmoidoscopies were performed at baseline, days 7, 42 and 98. Ulcerative colitis endoscopic index of severity (UCEIS) and its sub-scores - vascular pattern, bleeding and ulceration/erosion - were post-hoc calculated. Global endoscopic remission was defined by a UCEIS of 0, and partial endoscopic remission by any UCEIS sub-score of 0. RESULTS: Among the 55 patients analyzed (29 infliximab and 26 cyclosporine), 49 (83%) had UCEIS >= 6 at baseline at baseline. Partial endoscopic remission rates were higher for bleeding than for vascular pattern and for ulcerations/erosions at day 7 (20% vs. 4% and 5% (n = 55); p CONCLUSION: In steroid-refractory ASUC patients responding to a second-line medical therapy, endoscopic remission process started with bleeding remission and was not achieved in half the patients at day 98 for vascular pattern. Infliximab provided a higher endoscopic remission rate than cyclosporine at day 98.Peer reviewe

ECORS - Truc Vert 2008 : Qualification des modèles de houle et de morphodynamique

Cet article présente une campagne expérimentale internationale de grande envergure qui s’est déroulée en Mars-Avril 2008 sur la côte aquitaine. Cette campagne a permis de mettre en oeuvre des instrumentations et méthodes innovantes afin de mesurer une vaste gamme de processus hydrodynamiques, sédimentaires et morphologiques en zone de surf et de jet de rive tout en couvrant des échelles temporelles de la milli secondes à plusieurs semaines et des échelles spatiales subcentimétriques à décamétriques. Cette campagne apportera un jeu de données unique avec des conditions énergétiques très fortes (Hs> 5m) pour comprendre les processus mais également pour améliorer et valider les modèles numériques.The aim of this paper is to present a large international field experiment that took place in March-April 2008 on the French Aquitanian coast. During this field experiment, both very small and large spatial and temporal scales have been explored concerning hydrodynamic, sedimentary and morphodynamic processes in the surf and swash zones using innovative methods. This field experiment, one of the largest to take place in Europe (with the COAST 3D project), will provide a unique data set to explore surf zone and swash processes and improve numerical models in presence of very energetic events (5 storms with Hs > 5m) on macrotidal multi-barred sandy beaches

Prise en charge et facteurs prédictifs de mortalité à court terme des patients agés de plus de 75 ans ayant une anémie ferriprive (Etude prospective de 111 patients)

PARIS13-BU Serge Lebovici (930082101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Devenir à long terme et facteurs prédictifs de récidive de l anémie dans une cohorte de 102 patients agés de plus de 75 ans, explorés pour une anémie ferriprive

PARIS13-BU Serge Lebovici (930082101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF