2-[(3,5-Diphenyl-1H-pyrazol-1-yl)meth­yl]pyridine

The title compound, C21H17N3, crystallizes with the phenyl ring in the 3-position coplanar with the pyrazole ring within 4.04 (5)°, whereas the phenyl ring in the 5-position forms a dihedral angle of 50.22 (3)° with the pyrazole ring. There is no ambiguity regarding the position of pyridine N atom, which could have exhibited disorder between the ortho positions of the ring

[Bis(pyridin-2-ylmethyl) ether]- trichloridorhodium(III) dichloromethane monosolvate : unusual hydrolysis of the methylene bridge in (pyrazolylmethyl)- pyridine

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(Pyrazolyl)pyridine ruthenium(III) complexes: Synthesis, kinetics of substitution reactions with thiourea and biological studies

Reactions of 2-bromo-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine (L1), 2,6-di (1H-pyrazol-1-yl) pyridine (L2) and 2,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)pyridine (L3) with RuCl3·3H2O led to the formation of their respective metal complexes [RuCl3(L1)] (1), [RuCl3(L2)] (2) and [RuCl3(L3)] (3). Solid state structure of complex 3 established the formation of a six-coordinate mononuclear compound in which L3 is tridentately bound. The order of reactivity of the studied complexes with thiourea (TU) nucleophile is in the form 1?>?2?>?3, in line with density functional theory (DFT) studies. The complexes displayed minimal cytotoxic activity against the HeLa cell line, consistent with molecular docking experiments which showed weaker DNA binding affinities

Palladium(II) complexes of tridentate bis(benzazole) ligands: Structural, substitution kinetics, DNA interactions and cytotoxicity studies.

Reactions of 2,6-bis(benzimidazol-2-yl)pyridine (L1), 2,6-bis(benzoxazol-2-yl)pyridine (L2), and 2,6-bis(benzothiazol-2-yl)pyridine (L3) with [Pd(NCMe)2Cl2] in the presence of NaBF4 afforded the corresponding Pd(II) complexes, [Pd(L1)Cl]BF4, PdL1; [Pd(L2)Cl]BF4, PdL2; [Pd(L3)Cl]BF4, PdL3; respectively, while reaction of bis[(1H-benzimidazol-2-yl)methyl]amine (L4) with [Pd(NCMe)2Cl2] afforded complex [Pd(L4)Cl]Cl, PdL4. Characterisation of the complexes was accomplished using NMR, IR, MS, elemental analyses and single crystal X-ray crystallography. Ligand substitution kinetics of these complexes by biological nucleophiles thiourea (Tu), L-methionine (L-Met) and guanosine 5'-diphosphate disodium salt (5-GMP) were examined under pseudo-first order conditions. The reactivity of the complexes decreased in the order: PdL1 > PdL2 > PdL3 > PdL4, ascribed to electronic effects. Density functional theory (DFT) supported this trend. Studies of interaction of the Pd(II) complexes with calf thymus DNA (CT-DNA) revealed strong binding affinities via intercalative binding mode. Molecular docking studies established associative non-covalent interactions between the Pd complexes and DNA. The in vitro cytotoxic activities of PdL1-PdL4 were assessed in cancer cell lines HeLa and MRC5-SV2 and a normal cell line MRC-5, using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. PdL1 exhibited cytotoxic potency and selectivity against HeLa cell that was comparable to cisplatin's. Complex PdL1, unlike cisplatin, did not significantly induce caspase-dependent apoptosis

Perspective and future prospects of tandem olefin oligomerization and Friedel–Crafts alkylation reactions catalyzed by iron, cobalt, nickel and palladium complexes

Late transition metal complexes in the presence of an EtAlCl2 co-catalyst promote in situ Friedel–Crafts alkylation of preformed olefin oligomers.</p