Genome wide association mapping of grain arsenic, copper, molybdenum and zinc in rice (Oryza sativa L.) grown at four international field sites

Peer reviewedPublisher PD

Change In Classroom Practice

Over the last ten years deliberate and determined efforts have been made to improve schooling. This book charts recent and current developments in the practical business of changing classroom practice to make schools more effective. It is devoted to detecting the effects on classroom practice of the efforts made to improve schools and classrooms, and to understanding how classroom practice changes. Contributors include advisory teachers, Higher Education HE tutors and researchers, and work described ranges from early years' classrooms to post-experience course outcomes and the tracking of Inservice education and training INSET effectiveness

Atria, Roof-space Solar Collectors and Windows for Low-energy New and Renovated Office Buildings: a Review

As part of achieving near zero energy office buildings, solar gains can be optimised by built form, internal layout and the position, type and area of windows. Those solar gains can then displace heating and lighting energy in most non- domestic buildings without overt engineered solar energy harnessing features. Such approaches have been adopted to successfully realise many low-energy buildings. This review discusses key parameters and the particular challenges in the design of atria, windows and roof-space solar air heaters to reduce energy and carbon emissions associated with heating and lighting in newly-built and renovated non-domestic buildings

Tri-Design: Coordination between Healthcare, Design, and Regulatory Communities

This paper discusses the approaches undertaken by organizations, coordination between healthcare, design, and regulatory communities, to respond to the needs for the crisis and bring about models for agile innovation and of disease mitigation. The COVID-19 Design Innovation was born at the core of a major university to operate as a hub for innovation.  In an effort to connect designers, makers, and healthcare professionals, the initiative converged with the main motivation is to be organized in collective efforts with the crisis and deliver creative design innovations. Several products were brought about through the initiative efforts: off the shelf solutions and community driven, hybrid prototyping (reutilizing parts), distributed manufacturing, material investigations, and rapid prototyping for turning labs as manufacturing facilities. As solutions reached refinement, healthcare called for volume, solutions were brought to the community as a rapid response to the crisis. While challenges imposed by time and production, the crisis help coordinate efforts to be agile networks of stakeholders working towards a common goal, hacking the crisis by design

Modeling political improvement through statistical analysis of New Zealand’s Youth

Some things look better on paper than in person. Prior to my three-month stay in New Zealand, I wrongly assumed that the country’s history of economic success and involved voters would translate to somewhere without conflict. What I found is a country riddled with problems

Yes, one-day international cricket 'in-play' trading strategies can be profitable!

In this study, we employ a Monte Carlo simulation technique for estimating the conditional probability of victory at any stage in the first or second innings of a one-day international (ODI) cricket match. This model is then used to test market efficiency in the Betfair 'in-play' market for large sample of ODI matches. We find strong evidence of overreaction in the first innings. A trading strategy of betting on the batting team after the fall of a wicket produces a significant profit of 20%. We also find some evidence of underreaction in the second innings although it is less economically and statistically significant than the first innings overreaction. We also implement trades when the discrepancy between the probability of victory implied by current market odds differs substantially from the odds estimated by our Monte Carlo simulation model. We document a number of trading strategies that yield large statistically significant positive returns in both the first and second innings

Health and equity in New Hampshire: 2013 report card

Analysis of key health disparities among New Hampshire\u27s minority populations

Freedom of expression, accountability and development in the Arab region

Mechanisms for ensuring government transparency and accountability have yet to become established in the Arab region, where oil rents and security rents have traditionally enabled governments to provide jobs and services without having to rely heavily, if at all, on raising revenue through personal income tax on citizens. Yet various forms of resource mobilisation, which will be needed in future, are likely to require a greater degree of accountability from those responsible for such mobilisation. This paper considers whether a move in this direction is under way. It reviews government approaches to freedom of expression in the media and among non-governmental organisations. It notes changes that have taken place in this sphere since the start of the 1990s, not all of them positive, and concludes that many more steps remain to be taken if media organisations and NGOs are to exert pressure for accountability on behalf of citizens, and especially the disadvantaged

ZFP36L1 negatively regulates plasmacytoid differentiation of BCL1 cells by targeting BLIMP1 mRNA

The ZFP36/Tis11 family of zinc-finger proteins regulate cellular processes by binding to adenine uridine rich elements in the 3′ untranslated regions of various mRNAs and promoting their degradation. We show here that ZFP36L1 expression is largely extinguished during the transition from B cells to plasma cells, in a reciprocal pattern to that of ZFP36 and the plasma cell transcription factor, BLIMP1. Enforced expression of ZFP36L1 in the mouse BCL1 cell line blocked cytokine-induced differentiation while shRNA-mediated knock-down enhanced differentiation. Reconstruction of regulatory networks from microarray gene expression data using the ARACNe algorithm identified candidate mRNA targets for ZFP36L1 including BLIMP1. Genes that displayed down-regulation in plasma cells were significantly over-represented (P = <0.0001) in a set of previously validated ZFP36 targets suggesting that ZFP36L1 and ZFP36 target distinct sets of mRNAs during plasmacytoid differentiation. ShRNA-mediated knock-down of ZFP36L1 in BCL1 cells led to an increase in levels of BLIMP1 mRNA and protein, but not for mRNAs of other transcription factors that regulate plasmacytoid differentiation (xbp1, irf4, bcl6). Finally, ZFP36L1 significantly reduced the activity of a BLIMP1 3′ untranslated region-driven luciferase reporter. Taken together, these findings suggest that ZFP36L1 negatively regulates plasmacytoid differentiation, at least in part, by targeting the expression of BLIMP1