Wirkung auf Lernerfolg und Motivation durch Debriefing in Unternehmensplanspielen

Ausgelöst durch den Strukturwandel und die damit einhergehende Tertiarisierung im Dienstleistungssektor werden heutzutage höhere Anforderungen an Auszubildende gestellt. Es ergeben sich neue Tätigkeits- und Kompetenzprofile im Bereich Wissen, Kommunikations- und Problemlösefähigkeit. An erster Stelle steht dabei die Kommunikation mit Personen und die Fähigkeit zum Umgang mit Wissen, d. h. der Umgang mit Symbolen und Abstraktionen, Denken und Handeln in komplexen Zusammenhängen, stärkeres Engagement und Selbststeuerungsfähigkeit und die Fähigkeit und Bereitschaft zu ständigem Lernen. Die Berufsausbildungssysteme in Deutschland geraten vor dem Hintergrund dieser Veränderungen mehr und mehr in die Bedrängnis, auf der einen Seite keine grundlegend veränderten Fähigkeiten von Schulabgängern aus dem allgemeinbildenden System vorzufinden, diese aber auf veränderte und zumeist deutlich höhere berufliche Anforderungen vorbereiten zu müssen. [...] Die Forschungsfrage der vorliegenden Arbeit lautet demnach: „Beeinflusst der Einsatz von Debriefing-Methoden im Unterricht mit dem komplexen Lehr-Lern-Arrangement Planspiel die Höhe der Motivation und des Lernerfolges von Auszubildenden in der Berufsschule?” (DIPF/Orig.

Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND)

A key challenge in medical imaging is determining a precise correspondence between image properties and tissue microstructure. This comparison is hindered by disparate scales and resolutions between medical imaging and histology. We present a new technique, 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND), for registering medical images with 3D histology to overcome these limitations. Ex vivo 120 × 120 × 200 μm resolution diffusion-MRI (dMRI) data was acquired at 7 T from adult C57Bl/6 mouse hippocampus. Tissue was then optically cleared using CLARITY and stained with cellular markers and confocal microscopy used to produce high-resolution images of the 3D-tissue microstructure. For each sample, a dense array of hippocampal landmarks was used to drive registration between upsampled dMRI data and the corresponding confocal images. The cell population in each MRI voxel was determined within hippocampal subregions and compared to MRI-derived metrics. 3D-BOND provided robust voxel-wise, cellular correlates of dMRI data. CA1 pyramidal and dentate gyrus granular layers had significantly different mean diffusivity (p > 0.001), which was related to microstructural features. Overall, mean and radial diffusivity correlated with cell and axon density and fractional anisotropy with astrocyte density, while apparent fibre density correlated negatively with axon density. Astrocytes, axons and blood vessels correlated to tensor orientation

Impact of Dementia Behavioral Crises Events on First Responder and Family Systems in Idaho: An Exploratory Study

Enhancing quality of life for people with dementia is identified in Healthy People 2020 as a public health priority. In Idaho, the proportion of individuals diagnosed with Alzheimer’s disease and related dementias (ADRD) is projected to increase by 81 % - 127 % between 2000 and 2025. Policies designed to address needs of this population must be based on an understanding of system wide impacts of disease. The purpose of this exploratory study was to examine the impact of behavioral crises related to dementia on first responders. For the purpose of this study, “first responders” were defined as individuals employed by the Idaho Department of Health and Welfare Mobile Crisis Unit in Regions 1, 3, and 4, Ada County Paramedics/EMS, and social workers employed in health care settings in the Treasure Valley. A mixed methods design was used with information gathered from incident reports from the Ada County Paramedics and focus groups and interviews with key informants. Ada County Paramedics/EMS receives approximately 22,000 calls annually with 924 of calls related to behavioral crisis involving individuals with ADRD. Most calls were from assisted living facilities (n=401), home (n=290), or skilled nursing facilities (n=181). The majority (80%) of calls resulted in transport to a hospital emergency department (ED); none of the calls required use of lights or siren. Annual costs of calls to EMS and ED were estimated to be $457,380 and$905,020, respectively. Themes from key informants included: an increase in number and complexity of calls; lack of appropriate protocols within systems to support individual in crisis or their family or caregiver; and need for training on progression of ADRD and de-escalation strategies

On the Evaluation of Silicon Photomultipliers for Use as Photosensors in Liquid Xenon Detectors

Silicon photomultipliers (SiPMs) are potential solid-state alternatives to traditional photomultiplier tubes (PMTs) for single-photon detection. In this paper, we report on evaluating SensL MicroFC-10035-SMT SiPMs for their suitability as PMT replacements. The devices were successfully operated in a liquid-xenon detector, which demonstrates that SiPMs can be used in noble element time projection chambers as photosensors. The devices were also cooled down to 170 K to observe dark count dependence on temperature. No dependencies on the direction of an applied 3.2 kV/cm electric field were observed with respect to dark-count rate, gain, or photon detection efficiency.Comment: This is an author-created, un-copyedited version of an article accepted for publication/published in Journal of Instrumentation. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1088/1748-0221/13/03/C0304

Hepatic acute phase response protects the brain from focal inflammation during postnatal window of susceptibility

Perinatal inflammation is known to contribute to neurodevelopmental diseases. Animal models of perinatal inflammation have revealed that the inflammatory response within the brain is age dependent, but the regulators of this variation remain unclear. In the adult, the peripheral acute phase response (APR) is known to be pivotal in the downstream recruitment of leukocytes to the injured brain. The relationship between perinatal brain injury and the APR has not been established. Here, we generated focal inflammation in the brain using interleukin (IL)-1β at postnatal day (P)7, P14, P21 and P56 and studied both the central nervous system (CNS) and hepatic inflammatory responses at 4 h. We found that there is a significant window of susceptibility in mice at P14, when compared to mice at P7, P21 and P56. This was reflected in increased neutrophil recruitment to the CNS, as well as an increase in blood–brain barrier permeability. To investigate phenomena underlying this window of susceptibility, we performed a dose response of IL-1β. Whilst induction of endogenous IL-1β or intercellular adhesion molecule (ICAM)-1 in the brain and induction of a hepatic APR were dose dependent, the recruitment of neutrophils and associated blood–brain barrier breakdown was inversely proportional. Furthermore, in contrast to adult animals, an additional peripheral challenge (intravenous IL-1β) reduced the degree of CNS inflammation, rather than exacerbating it. Together these results suggest a unique window of susceptibility to CNS injury, meaning that suppressing systemic inflammation after brain injury may exacerbate the damage caused, in an age-dependent manner