MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia

AML/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed

Presentation on Marlon James\u27s The Book of Night Women Day 1

The first in a series of presentations on Marlon James\u27s The Book of Night Women

Lessons from the polis : the Minneapolis Museum of Art

Philosophers Alberto Pérez-Gómez and Hans-Georg Gadamer have critiqued the modern museum as a place of art for the sake of art, where the aesthetics of the work have come to dominate the conversation. In the Relevance of the Beautiful, Hans-Georg Gadamer distinguishes between aesthetics and a works poetic beauty as a delicate interplay of showing and concealing. The beautiful is presented through play, symbol and festival. This thesis explores Gadamer and Pérez-Gómez’s arguments in an architecture which blends influence from the ancient Greek Polis. The Agora a vital public space dedicated itself to the success and longevity of the Greek Polis. It was space of participation which relied on an overlapping of one- self and the artifacts/rituals of Greek culture. Like the Agora this museum seeks to envelope visitors in an atmosphere, which unfolds and frames not only the artwork but also opportunities to gather and discuss the works of art. The sinuous flow of conversations and exhibits are supported by residencies, which broaden the discussion by inviting the participation of local and distant thinkers. Restoring the labyrinthine experience of the work of art through conversation

Mixed-methods study identifying key intervention targets to improve participation in daily living activities in primary Sjögren's syndrome patients

Objective: Functional ability and participation in life situations are compromised in many primary Sjögren's syndrome (SS) patients. This study aimed to identify the key barriers and priorities to participation in daily living activities, in order to develop potential future interventions. Methods: Group concept mapping, a semiquantitative, mixed‐methods approach was used to identify and structure ideas from UK primary SS patients, adult household members living with a primary SS patient, and health care professionals. Brainstorming generated ideas, which were summarized into a final set of statements. Participants individually arranged these statements into themes and rated each statement for importance. Multidimensional scaling and hierarchical cluster analysis were applied to sorted and rated data to produce visual representations of the ideas (concept maps), enabling identification of agreed priority areas for interventions. Results: A total of 121 patients, 43 adult household members, and 67 health care professionals took part. In sum, 463 ideas were distilled down to 94 statements. These statements were grouped into 7 clusters: Patient Empowerment, Symptoms, Wellbeing, Access and Coordination of Health Care, Knowledge and Support, Public Awareness and Support, and Friends and Family. Patient Empowerment and Symptoms were rated as priority conceptual themes. Important statements within priority clusters indicate patients should be taken seriously and supported to self‐manage symptoms of oral and ocular dryness, fatigue, pain, and poor sleep. Conclusion: Our data highlighted the fact that in addition to managing primary SS symptoms, interventions aiming to improve patient empowerment, general wellbeing, access to health care, patient education, and social support are important to facilitate improved participation in daily living activities

Modeling of Temperature Impacts on Fixed Film Microbial Growth and Nitrification Kinetics

Monod-type kinetic models, used in simulating microbial growth in biological treatment systems, suggest significant decreases of substrate utilization at lower temperatures. However, it is documented that performance of fixed film treatment systems are not hindered with declining temperatures. Previous studies at the Moorhead, MN, Wastewater Treatment Facility (WWTF) showed significant impacts of temperature on biofilm growth in its moving bed biofilm reactor (MBBR), and studies noted that at low temperatures more biomass was present. Previously, a series of kinetic bench-scale batch tests was performed to measure ammonium removal in the full-scale system. As part of this research, a diffusion based kinetic model was developed to simulate the bench-scale trials and determine if Monod kinetics and temperature corrections properly model fixed film systems. It was found that Monod kinetics and temperature corrections do apply to fixed film system as long as proper consideration is given to the change in biofilm characteristics

Presentation on Marlon James\u27s The Book of Night Women Day 2

The second in a series of presentations on Marlon James\u27s novel The Book of Night Women

Assessment of health‐related quality of life as an outcome measure in granulomatosis with polyangiitis (Wegener's)

Objective To assess a generic measure of health‐related quality of life (HRQOL) as an outcome measure in granulomatosis with polyangiitis (Wegener's) (GPA). Methods Subjects were participants in the Wegener's Granulomatosis Etanercept Trial (WGET) or the Vasculitis Clinical Research Consortium Longitudinal Study (VCRC‐LS). HRQOL was assessed with the Short Form 36 (SF‐36) health survey that includes physical and mental component summary scores (PCS and MCS, respectively). Disease activity was assessed with the Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG). Results The data from 180 subjects in the WGET (median followup 2.3 years, mean number of visits 10) and 237 subjects in the VCRC‐LS (median followup 2.0 years, mean number of visits 8) were analyzed. A 1 unit increase in the BVAS/WG corresponded to a 1.15 unit (95% confidence interval [95% CI] 1.02, 1.29) decrease for the PCS and a 0.93 (95% CI 0.78, 1.07) decrease for the MCS in the WGET, and to a 1.16 unit decrease for the PCS (95% CI 0.94, 1.39) and a 0.79 unit decrease for the MCS (95% CI 0.51, 1.39) in the VCRC‐LS. In both arms of the WGET study, SF‐36 measures improved rapidly during the first 6 weeks of treatment followed by gradual improvement among patients achieving sustained remission (0.5 improvement in PCS per 3 months), but worsened slightly (0.03 decrease in PCS every 3 months) among patients not achieving sustained remission ( P = 0.005). Conclusion HRQOL, as measured by the SF‐36, is reduced among patients with GPA. SF‐36 measures are modestly associated with other disease outcomes and discriminate between disease states of importance in GPA.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90377/1/20649_ftp.pd