O Come all ye thinking types : the wider appeal of the cathedral carol service

Psychological type profiles of Anglican clergy and of Anglican congregations routinely direct attention to the over-representation of feeling types, and to the consequent under-representation of thinking types. The present study of 164 men and 239 women who completed the Francis Psychological Types Scales in the context of a cathedral carol service found a higher proportion of thinking types in this congregation than in the regular Sunday congregations of parish churches. The implications of these findings are discussed for the development of cathedral ministry

480Mbit/s UWB bi-directional radio over fiber CWDM PON using ultra-low cost and power VCSELs

Radio-over-fiber (RoF) schemes offer the possibility of permitting direct access to native format services for the domestic user. A low power requirement and cost effectiveness are crucial to both the service provider and the end user. Here, we present an ultra-low cost and power RoF scheme using direct modulation of commercially-available 1344 nm and 1547 nm VCSELs by band-group 1 UWB wireless signals (ECMA-368) at near broadcast power levels. As a result, greatly simplified electrical-optical-electrical conversion is accomplished. A successful demonstration over a transmission distance of 20.1 km is described using a SSMF, CWDM optical network. EVMs of better than-18.3 dB were achieved. © 2011 Optical Society of America

Phytochrome A mediates blue-light enhancement of second-positive phototropism in Arabidopsis

Hypocotyl phototropism of etiolated Arabidopsis seedlings is primarily mediated by the blue-light receptor kinase phototropin 1 (phot1). Phot1-mediated curvature to continuous unilateral blue light irradiation (0.5 µmol m-2 s-1) is enhanced by overhead pre-treatment with red light (20 µmol m-2 s-1 for 15 min) through the action of phytochrome (phyA). Here, we show that pre-treatment with blue light is equally as effective in eliciting phototropic enhancement and is dependent on phyA. Although blue pre-treatment was sufficient to activate early phot1 signalling events, phot1 autophosphorylation in vivo was not found to be saturated, as assessed by subsequently measuring phot1 kinase activity in vitro. However, enhancement effects to red and blue pre-treatment were not observed at higher intensities of phototropic stimulation (10 µmol m-2 s-1). Phototropic enhancement to red and blue pre-treatments to 0.5 µmol m-2 s-1 unilateral blue light irradiation was also lacking in transgenic Arabidopsis where PHOT1 expression was restricted to the epidermis. Together, these findings indicate that phyA-mediated effects on phot1 signalling are restricted to low intensities of phototropic stimulation and originate from tissues other than the epidermis

The South African Medicines Control Council: Comparison of Its Registration Process With Australia, Canada, Singapore, and Switzerland

© 2019 Keyter, Salek, Banoo and Walker.Introduction: Comparisons between regulatory authorities of similar size and regulatory characteristics facilitate value-added benchmarking and provide insight into regulatory performance. Such comparisons highlight areas for improvement as authorities move toward achieving their regulatory goals and stakeholders’ demands. The aims of this study were to compare the registration process and the regulatory review model of the South African Medicines Control Council (MCC) to that of four other similar-sized regulatory authorities and to identify areas for improvement that may inform recommendations to the South African Health Products Regulatory Authority (SAHPRA) as it looks to re-engineer and enhance the registration process in South Africa. Methods: A questionnaire describing the organisational structure, the registration process, good review and decision-making practices of the MCC was completed by the author (AK) for the purpose of this study and validated by the Registrar of the MCC. Similar questionnaires were also completed and validated by Australia’s Therapeutic Goods Administration (TGA), Canada’s Health Canada, Singapore’s Health Science Authority (HSA) and Switzerland’s Swissmedic. Results: A comparison of the MCC regulatory process with the four comparative agencies indicated that they all have similar requirements and employ a full-review model although the timelines for the MCC were considerably longer. However, similar quality measures were implemented by all authorities as part of their good review practices (GRevP) including prioritising transparency, communication, continuous improvement initiatives and training. Conclusion: Comparisons made through this study provided insight into the areas of the MCC registration process that may be improved and have informed recommendations to SAHPRA including the implementation of facilitated regulatory pathways, definition of targets for key milestones in regulatory review and formal implementation and monitoring of GRevP. In order to build quality into the review process the application of a standardised template for the clinical assessment of medicines such as the Universal Methodology for Benefit-Risk Assessment (UMBRA) could be considered as well as enhancing transparency and communication through the application of an electronic management system and the development of publicly available summaries for the basis of approval.Peer reviewedFinal Published versio

A narrowing of meaning:loss of narrative unity and the nature of design change

This paper seeks to explore where design might best focus its efforts with respect to contemporary concerns about sustainability, particularly in view of the magnitude and nature of change required. The discussion traces the long entrenchment, over several centuries, of assumptions, conventions and outlooks that resulted in a shift in worldview from traditional to modern/late-modern. This shift is not only associated with unprecedented environmental damage, but also with a narrower perspective, a loss of narrative unity, and a loss of meaning. The argument is made that, by focusing on rationalistic, techno-scientific solutions design restricts its contribution to a variety of incremental changes that actually support the continuance of a fundamentally unsustainable system. Instead, design can widen its purview and be a catalyst for more substantive change by restoring a more balanced approach to products and processes in context; thereby contributing to a recovery of narrative unity and meaning

Experimental Studies of Turbulent Intensity around a Tidal Turbine Support Structure

Tidal stream energy is a low-carbon energy source. Tidal stream turbines operate in a turbulent environment, and the effect of the structure between the turbine and seabed on this environment is not fully understood. An experimental study using 1:72 scale models based on a commercial turbine design was carried out to study the support structure influence on turbulent intensity around the turbine blades. The study was conducted using the wave-current tank at the Laboratory of Maritime Engineering (LABIMA), University of Florence. A realistic flow environment (ambient turbulent intensity = 11%) was established. Turbulent intensity was measured upstream and downstream of a turbine mounted on two different support structures (one resembling a commercial design, the other the same with an additional vertical element), in order to quantify any variation in turbulence and performance between the support structures. Turbine drive power was used to calculate power generation. Acoustic Doppler velocimetry (ADV) was used to record and calculate upstream and downstream turbulent intensity. In otherwise identical conditions, performance variation of only 4% was observed between two support structures. Turbulent intensity at 1, 3 and 5 blade diameters, both upstream and downstream, showed variation up to 21% between the two cases. The additional turbulent structures generated by the additional element of the second support structure appears to cause this effect, and the upstream propagation of turbulent intensity is believed to be permitted by surface waves. This result is significant for the prediction of turbine array performance

A peer-to-peer infrastructure for resilient web services

This work is funded by GR/M78403 “Supporting Internet Computation in Arbitrary Geographical Locations” and GR/R51872 “Reflective Application Framework for Distributed Architectures”, and by Nuffield Grant URB/01597/G “Peer-to-Peer Infrastructure for Autonomic Storage Architectures”This paper describes an infrastructure for the deployment and use of Web Services that are resilient to the failure of the nodes that host those services. The infrastructure presents a single interface that provides mechanisms for users to publish services and to find hosted services. The infrastructure supports the autonomic deployment of services and the brokerage of hosts on which services may be deployed. Once deployed, services are autonomically managed in a number of aspects including load balancing, availability, failure detection and recovery, and lifetime management. Services are published and deployed with associated metadata describing the service type. This same metadata may be used subsequently by interested parties to discover services. The infrastructure uses peer-to-peer (P2P) overlay technologies to abstract over the underlying network to deploy and locate instances of those services. It takes advantage of the P2P network to replicate directory services used to locate service instances (for using a service), Service Hosts (for deployment of services) and Autonomic Managers which manage the deployed services. The P2P overlay network is itself constructed using novel Web Services-based middleware and a variation of the Chord P2P protocol, which is self-managing.Postprin