A facile atom economic one pot multicomponent synthesis of bioactive spiro-indenoquinoxaline pyrrolizines as potent antioxidants and anti-cancer agents

One pot method for the synthesis of biologically active novel spiro-indenoquinoxaline pyrrolizines by means of four-component reaction between ninhydrin, o-phenylenediamine, l-proline and quinolinyl chalcones in methanol via [3+2] cycloaddition.</p

A facile regio- and stereoselective synthesis of novel spiro[indolin-3,2′-pyrrolidin]-2-one’s <i>via</i> 1,3-dipolar cycloaddition of azomethine ylides

<p>A facile regio and stereoselective synthesis of novel spiro[indolin-3,2′-pyrrolidin]-2-one’s have been accomplished through 1,3-dipolar cycloaddition of azomethine ylides generated <i>in situ</i> from the reaction of isatin and benzyl amine with quinoline bearing dipolarophiles in good yields. The synthesized compounds were well characterized through different spectroscopic techniques, such as single crystal XRD, FTIR, NMR, and mass spectral analysis.</p