Localised Laryngeal Amyloidosis Endoscopic Excision -A Case Report

Abstract:We report a case of primary laryngeal amyloidosis in a 35 year old adult patient who presented with hoarseness of voice for 6 months duration with no other symptoms. Patient was treated successfully with endoscopic excision using a microdebrider with a laryngeal blade and review of literature.Keywords: laryngeal amyloid .  Endoscopy . Debrider

(Anti-)Symmetrizing Wave Functions

The construction of fully (anti-)symmetric states with many particles, when the single particle state carries multiple quantum numbers, is a problem that seems to have not been systematically addressed in the literature. A quintessential example is the construction of ground state baryon wave functions where the color singlet condition reduces the problem to just two (flavor and spin) quantum numbers. In this paper, we address the general problem by noting that it can be re-interpreted as an eigenvalue equation, and provide a formalism that applies to generic number of particles and generic number of quantum numbers. As an immediate result, we find a complete solution to the two quantum number case, from which the baryon wave function problem with arbitrary number of flavors follows. As a more elaborate illustration that reveals complications not visible in the two quantum number case, we present the complete class of states possible for a system of five fermionic particles with three quantum numbers each. Our formalism makes systematic use of properties of the symmetric group and Young tableaux. Even though our motivations to consider this question have their roots in SYK-like tensor models and holography, the problem and its solution should have broader applications.Comment: v3: journal version, contains slightly expanded discussions and example

Escherichia coli K1 Modulates Peroxisome Proliferator–Activated Receptor γ and Glucose Transporter 1 at the Blood-Brain Barrier in Neonatal Meningitis

Escherichia coli K1 meningitis continues to be a major threat to neonatal health. Previous studies demonstrated that outer membrane protein A (OmpA) of E. coli K1 interacts with endothelial cell glycoprotein 96 (Ecgp96) in the blood-brain barrier to enter the central nervous system. Here we show that the interaction between OmpA and Ecgp96 downregulates peroxisome proliferator–activated receptor γ (PPAR-γ) and glucose transporter 1 (GLUT-1) levels in human brain microvascular endothelial cells, causing disruption of barrier integrity and inhibition of glucose uptake. The suppression of PPAR-γ and GLUT-1 by the bacteria in the brain microvessels of newborn mice causes extensive pathophysiology owing to interleukin 6 production. Pretreatment with partial or selective PPAR-γ agonists ameliorate the pathological outcomes of infection by suppressing interleukin 6 production in the brain. Thus, inhibition of PPAR-γ and GLUT-1 by E. coli K1 is a novel pathogenic mechanism in meningitis, and pharmacological upregulation of PPAR-γ and GLUT-1 levels may provide novel therapeutic avenues

IMPACT OF INTERNET IN ACADEMIC EFFICIENCY OF STUDENTS AMONG ENGINEERING GRADUATES

In the modern digital world, Internet service play a crucial role in enriching new trends among young graduates. Internet have empowered new technology to young learners to progress their academic work. It is very essential to measure the impact of internet service among engineering graduates which paved the way for higher studies and employment. Digital era may oblige to learn everything in their routine life with new techniques. In this study, questionnaire is structured and issued to 180 engineering graduates around 3 colleges in Tirunelveli district. Out of 180, 164 responded and get collected. After analyzing , we came to know that 44.43 % of the respondent have strongly agree the positive impact in their academic way. In turn, 41.29% of the respondent have strongly agree the negative impact in their academic way

Photoemission Studies of Magnetic Systems.

I have studied the electronic structure of thin films by photoelectron spectroscopy. My results show that even a monolayer film of Ni/Cu(001) exhibits bulk-like electronic structure and resembles that of bulk Ni. In order to better understand this result, I tracked the sp-band dimension at the Fermi surface of the Ni films for various coverages. For submonolayer coverages of Ni, the sp-band dimension was smaller than that of bulk Cu, but quickly reached that of bulk Ni by 1.2 ML Ni coverage. This continuous decrease implies a charge transfer from the Cu substrate to the Ni film, resulting in a decrease in the filling of the Cu sp-band. This transfer of electronic charge could provide a mechanism for hybridization at the Cu/Ni interface and result in a larger penetration of the film electronic states into the substrate. To quantify the charge transfer, the reverse system of Cu/Ni(001) was studied. Again the sp-band dimension for 45 eV photons was studied as a function of Cu thickness. The change in the sp-band dimension was related to reduced filling in the sp-band of bulk Cu. This corresponded to a reduction of $\sim$0.5 eV in the band-filling of bulk Cu. From the integrated density of states, this was identified to be a charge depletion of $\sim$0.12 electrons/atom for the monolayer film. This shift was observed in core level spectra across the 3p levels, corroborating the assumption

Bounding the Optimal Length of Pliable Index Coding via a Hypergraph-based Approach

In pliable index coding (PICOD), a number of clients are connected via a noise-free broadcast channel to a server which has a list of messages. Each client has a unique subset of messages at the server as side-information and requests for any one message not in the side-information. A PICOD scheme of length $\ell$ is a set of $\ell$ encoded transmissions broadcast from the server such that all clients are satisfied. Finding the optimal (minimum) length of PICOD and designing PICOD schemes that have small length are the fundamental questions in PICOD. In this paper, we use a hypergraph-based approach to derive new achievability and converse results for PICOD. We present an algorithm which gives an achievable scheme for PICOD with length at most $\Delta(\mathcal{H})$, where $\Delta(\mathcal{H})$ is the maximum degree of any vertex in a hypergraph that represents the PICOD problem. We also give a lower bound for the optimal PICOD length using a new structural parameter associated with the PICOD hypergraph called the nesting number. We extend some of our results to the PICOD problem where each client demands $t$ messages, rather than just one. Finally, we identify a class of problems for which our converse is tight, and also characterize the optimal PICOD lengths of problems with $\Delta(\mathcal{H})\in\{1,2,3\}$.Comment: Accepted at the IEEE Information Theory Workshop, 202

Development of biomaterial scaffold for nerve tissue engineering: Biomaterial mediated neural regeneration

Neural tissue repair and regeneration strategies have received a great deal of attention because it directly affects the quality of the patient's life. There are many scientific challenges to regenerate nerve while using conventional autologous nerve grafts and from the newly developed therapeutic strategies for the reconstruction of damaged nerves. Recent advancements in nerve regeneration have involved the application of tissue engineering principles and this has evolved a new perspective to neural therapy. The success of neural tissue engineering is mainly based on the regulation of cell behavior and tissue progression through the development of a synthetic scaffold that is analogous to the natural extracellular matrix and can support three-dimensional cell cultures. As the natural extracellular matrix provides an ideal environment for topographical, electrical and chemical cues to the adhesion and proliferation of neural cells, there exists a need to develop a synthetic scaffold that would be biocompatible, immunologically inert, conducting, biodegradable, and infection-resistant biomaterial to support neurite outgrowth. This review outlines the rationale for effective neural tissue engineering through the use of suitable biomaterials and scaffolding techniques for fabrication of a construct that would allow the neurons to adhere, proliferate and eventually form nerves