Comparative Evaluation of Initial and Reduced Retention Force of Two Different Soft Liners over Ball Abutments for Mandibular Implant Overdentures: An Invitro study

PURPOSE: This study was conducted to comparatively evaluate the initial and reduced retention force of two different soft liners over ball abutments for mandibular implant overdentures. MATERIALS AND METHODS: Two implants corresponding to 33 and 43 were placed in a mandibular edentulous heat cure master model with ball abutments of 3mm diameter and 0.5 mm collar height. Overdentures were processed in heat activated denture base resin and divided into three groups of group A (n=15), group B (n=15) and group C (n=15). Group A lined with ufi-gel P followed with group B lined with Molloplast B and group C polymerised with plastic caps. Each of 45 denture bases were subjected to initial retention force and reduced retention force testing after 3348 cycles using servohydraulic testing machine. The dual recess areas of the soft liner bonded to denture base was observed with a stereomiroscope both before and after 3348 cycles. Statistical analysis was performed using Anova Kruskal Wallis test and Wilcoxon signed rank test. RESULTS: There were insignificant differences (P > 0.05) in the mean rank values of all the three groups for reduced retention force after 3348 cycles and percentage reduction in force. There were significant differences in all the three groups between initial retention force and reduced retention force after 3348 cycles (P <0.05). CONCLUSION: Both the liners could be used as attachments for mandibular implant overdentures over the 3 year simulation period

Definitive Dental Applications of Graphene Based Dental Biomaterial

Graphene was first identified in 2004, and it has remarkable properties. Atoms of Graphene are very tightly bonded so, like carbon nanotubes, which makes it super-strong, even more, potent than diamond. Moreover, it has good Heat conductivity, Electrical conductivity, and optical properties. Application in the dental field, especially in prosthodontics, includes the addition to Polymethylmethacrylate and improving its properties. In removable and implant prosthodontics in the last five years, this biomaterial had evoked immense research interest.</jats:p

A dual non-ATP analogue inhibitor of aurora kinases A and B, derived from resorcinol with a mixed mode of inhibition

Aurora kinases are the most commonly targeted mitotic kinases in the intervention of cancer progression. Here, we report a resorcinol derivative, 5‐methyl‐4‐(2‐thiazolylazo) resorcinol (PTK66), a dual inhibitor of Aurora A and Aurora B kinases. PTK66 is a surface binding non‐ATP analogue inhibitor that shows a mixed pattern of inhibition against both of Aurora A and B kinases. The in vitro IC₅₀ is approximately 47 and 40 &#956;M for Aurora A and Aurora B kinases, respectively. In cellular systems, PTK66 exhibits a substantially low cytotoxicity at micromolar concentrations but it can induce aneuploidy under similar dosages as a consequence of Aurora kinase inhibition. This result was corroborated by a drop in the histone H3 (S10) phosphorylation level detected via Western blot analysis using three different cell types. Altogether, our findings indicate that the ligand containing resorcinol backbone is one of the novel scaffolds targeting the Aurora family of kinases, which could be a target for antineoplastic drug development