2,251 research outputs found
ECONOMICS OF TECHNICAL CHANGE IN WHEAT PRODUCTION IN PUNJAB (INDIA)
Crop Production/Industries, Research and Development/Tech Change/Emerging Technologies,
THE PRODUCTIVE VALUE OF EDUCATION IN AGRICULTURAL DEVELOPMENT
The purpose of this paper is to present some empirical evidence from a developing agriculture in northwestern India, evidence which shows that schooling of the farm people contributes to their useful productive abilities.International Development, Labor and Human Capital,
Municipal Solid Waste Management in Cities - Issues of Basic Rights of People Surrounding Village and Alternatives
The Study is based on the findings of a three weeklong field study conducted in Villappilsala, a village 14 kms away from Thriuvananthapuram City. The waste disposal plant for treating the Municipal Solid Waste generated in the Thiruvanathapuram City is located here. The study focuses on the health and environmental impacts of the functioning of the plant on the local community and addresses the larger question of necessity for scientific and cost effective alternative methods of waste disposal in the city itself. The disposal of Solid Waste has become a problem calling for more attention in the wake of urban development, which is the consequence of more people settling in the cities. The issue of decentralised and scientific disposal of Solid Waste at household level and at the level of small groups of households is emphasised. The central issue thrown up by this study is the poorer sections of the village folk bearing the brunt of the consequences of the profligate consumption and callous waste disposal habits of the upper classes in the citiesMUNICIPAL SOLID WASTE; BASIC RIGHTS; Villappilsala; health and environmental impacts
THE DEMAND FOR COTTON IN INDIA, 1952-1968
Crop Production/Industries, Demand and Price Analysis,
Evaluation of the extent of wetland birds in District Kaithal, Haryana, India
Kaithal District is comprised of 2317 Km² Sq. Km area having six blocks Viz.:Kaithal, Kalayat, Pundri, Rajound, Ghula and Siwan located at a distance of 150 Kms from New Delhi toward North West. Its geographical position lies between 29° 48' 0 N latitude and between 76° 22' 60 E longitude.The present studies were carried between 2005-2008 with the help of Zenith Camera and telelens. In all, 63 species of Wetland birds belonging to 10 Orders, 38 genera and 16 families were observed in various village ponds in Kaithal District. Out of 63 species of wetland birds, 31 are winter migratory, 9 local migratory, 3 summers migratory and 20 species are resident birds. Considering IUCN categories, Black Ibis (Pseudibis papillosa) which belongs to Biome Restricted Species (BRS) was observed in three blocks viz. Kaithal, Pundri and Rajound of Kaithal district. In addition, Spotted Greenshank (Tringa guttifer) which has been placed in endangered category of IUCN was observed as single individual. But Black Ibis (Pseudibis papillosa) was observed in a group of three to seven. Northern Shoveller (Anas clypeata), which is reportedly coming from Central Russia and Caspian Siberia has been observed in very large groups of 200-250 and virtually spotted in each and every pond in Northern Haryana. Similarly, Northern Pintail (Anas acuta), Common Teal (Anas crecca), Common Pochard (Aythya ferina), Spot-billed Duck (Anas poecilorhyncha), Lesser-whistling Teal (Dendrocygna javanica) were also seen in relatively large groups. Common Pochard (Aythya ferina) is always observed in pure groups floating in the centre of relatively big ponds. In contrast, Gadwall (Anas strepera), Northern Shoveller (Anas clypeata), Northern Pintail (Anas acuta) and Common Teal (Anas crecca), share close proximity with each other in water and are found in mixed groups. Northern Shoveller (Anas clypeata), Bar- headed Goose (Anser indicus) and Northern Pintail (Anas acuta) stay between Octobers to April. Mallard (Anas platyrhynchos) stays in winter for shortest period between December and January. Maximum wetland birds observed in Kaithal District belong to Order Charadriiformes and to family Anatidae of Order Anseriformes. Spotted Greenshank (Tringa guttifer) is the peculiar to Pundri block only, in Kaithal District
The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-κB activity by blocking ubiquitination mediated proteasomal degradation of IκBα in human hepatoma cells
Abstract
Background
Nuclear factor kappa B (NF-κB) is a key transcription factor that plays a crucial role in host survival during infection by pathogens. Therefore, it has been a priority of many pathogens to manipulate the cellular NF-κB activity in order to create a favorable environment for their survival inside the host.
Results
We observed that heterologous expression of the open reading frame 2 (ORF2) protein in human hepatoma cells led to stabilization of the cellular I kappa B alpha (IκBα) pool, with a concomitant reduction in the nuclear localization of the p65 subunit of NF-κB and inhibition of NF-κB activity. Although basal or TPA induced phosphorylation of IκBα was not altered, its ubiquitination was markedly reduced in ORF2 expressing cells. Further analysis revealed that ORF2 protein could directly associate with the F-box protein, beta transducin repeat containing protein (βTRCP) and ORF2 over expression resulted in reduced association of IκBα with the SKP1 and CUL1 components of the SCFβTRCP complex. Chromatin immunoprecipitation (ChIP) assay of the proximal promoter regions of MHC-I heavy chain and IL-8 genes using p65 antibody and LPS stimulated ORF2 expressing cell extract revealed decreased association of p65 with the above regions, indicating that ORF2 inhibited p65 binding at endogenous promoters.
Conclusions
In this report we suggest a mechanism by which ORF2 protein of HEV may inhibit host cell NF-κB activity during the course of a viral infection.
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