Review of centrifugal liquid-liquid chromatography using aqueous two-phase solvent (ATPS) systems: Its scale-up and prospects for the future production of high-value biologics

The future challenges in bioprocessing include developing new downstream processes for the purification and manufacture of the protein based medicines of the future to relieve the predicted bottleneck being produced by increasingly high titres from fermentation processes. This review looks at the recent developments in centrifugal liquid-liquid partition chromatography using aqueous two-phase solvent (ATPS) systems, a gentle host medium for biologics, and the prospect for scale-up and eventual manufacture of high value pharmaceutical products

Solitons in the Calogero-Sutherland Collective-Field Model

In the Bogomol'nyi limit of the Calogero-Sutherland collective-field model we find static-soliton solutions. The solutions of the equations of motion are moving solitons, having no static limit for \l>1. They describe holes and lumps, depending on the value of the statistical parametar \l.Comment: minor correction

On the oxide formation on stainless steels AISI 304 and incoloy 800H investigated with XPS

The influence of cold work on the initially formed oxide layer on the stainless steels AISI 304 and Incology 800H has been studied by XPS. Oxidations were performed at pressures of 10-6-10-4 Pa and temperatures of 300–800 K. All samples showed a similar oxidation behaviour. The oxidation rates of iron and chromium are of the same order of magnitude at temperatures below 650 K. Subsequent oxidation results in an iron oxide on top of a chromium oxide layer. At temperatures above 650 K the metal surface becomes enriched in chromium, which is preferentially oxidized at these temperatures and pressures. Even prolonged oxidation does not result in an iron-rich oxide surface. Nickel has never been found in its oxidized form. The binding energy of oxygen, in the various oxide layers, is independent of the extent of oxidation and is 530.6 eV

Subduction Duration and Slab Dip

The dip angles of slabs are among the clearest characteristics of subduction zones, but the factors that control them remain obscure. Here, slab dip angles and subduction parameters, including subduction duration, the nature of the overriding plate, slab age, and convergence rate, are determined for 153 transects along subduction zones for the present day. We present a comprehensive tabulation of subduction duration based on isotopic ages of arc initiation and stratigraphic, structural, plate tectonic and seismic indicators of subduction initiation. We present two ages for subduction zones, a long‐term age and a reinitiation age. Using cross correlation and multivariate regression, we find that (1) subduction duration is the primary parameter controlling slab dips with slabs tending to have shallower dips at subduction zones that have been in existence longer; (2) the long‐term age of subduction duration better explains variation of shallow dip than reinitiation age; (3) overriding plate nature could influence shallow dip angle, where slabs below continents tend to have shallower dips; (4) slab age contributes to slab dip, with younger slabs having steeper shallow dips; and (5) the relations between slab dip and subduction parameters are depth dependent, where the ability of subduction duration and overriding plate nature to explain observed variation decreases with depth. The analysis emphasizes the importance of subduction history and the long‐term regional state of a subduction zone in determining slab dip and is consistent with mechanical models of subduction

Exact spin-orbital separation in a solvable model in one dimension

A one-dimensional model of coupled spin-1/2 spins and pseudospin-1/2 orbitals with nearest-neighbor interaction is rigorously shown to exhibit spin-orbital separation by means of a non-local unitary transformation. On an open chain, this transformation completely decouples the spins from the orbitals in such a way that the spins become paramagnetic while the orbitals form the soluble XXZ Heisenberg model. The nature of various correlations is discussed. The more general cases, which allow spin-orbital separation by the same method, are pointed out. A generalization for the orbital pseudospin greater than 1/2 is also discussed. Some qualitative connections are drawn with the recently observed spin-orbital separation in Sr2CuO3.Comment: 5 page

One-pot synthesis of 5-amino-2,5-dihydro-1-benzoxepines: access to pharmacologically active heterocyclic scaffolds

A one-pot multibond-forming process involving a thermally mediated Overman rearrangement and a ring closing metathesis reaction of allylic trichloroacetimidates bearing a 2-allyloxyaryl group has been developed for the synthesis of 5-amino-substituted 2,5-dihydro-1-benzoxepines. Chemoselective reduction and functionalization of these compounds allowed access to a range of pharmacologically active 5-amino-2,3,4,5-tetrahydro-1-benzoxepine scaffolds

Quantum Disordered Ground States in Frustrated Antiferromagnets with Multiple Ring Exchange Interactions

We present a certain class of two-dimensional frustrated quantum Heisenberg spin systems with multiple ring exchange interactions which are rigorously demonstrated to have quantum disordered ground states without magnetic long-range order. The systems considered in this paper are s=1/2 antiferromagnets on a honeycomb and square lattices, and an s=1 antiferromagnet on a triangular lattice. We find that for a particular set of parameter values, the ground state is a short-range resonating valence bond state or a valence bond crystal state. It is shown that these systems are closely related to the quantum dimer model introduced by Rokhsar and Kivelson as an effective low-energy theory for valence bond states.Comment: 6 pages, 4 figure

Some Properties of the Calogero-Sutherland Model with Reflections

We prove that the Calogero-Sutherland Model with reflections (the BC_N model) possesses a property of duality relating the eigenfunctions of two Hamiltonians with different coupling constants. We obtain a generating function for their polynomial eigenfunctions, the generalized Jacobi polynomials. The symmetry of the wave-functions for certain particular cases (associated to the root systems of the classical Lie groups B_N, C_N and D_N) is also discussed.Comment: 16 pages, harvmac.te

Bunching Transitions on Vicinal Surfaces and Quantum N-mers

We study vicinal crystal surfaces with the terrace-step-kink model on a discrete lattice. Including both a short-ranged attractive interaction and a long-ranged repulsive interaction arising from elastic forces, we discover a series of phases in which steps coalesce into bunches of n steps each. The value of n varies with temperature and the ratio of short to long range interaction strengths. We propose that the bunch phases have been observed in very recent experiments on Si surfaces. Within the context of a mapping of the model to a system of bosons on a 1D lattice, the bunch phases appear as quantum n-mers.Comment: 5 pages, RevTex; to appear in Phys. Rev. Let