Strong and radiative decays of X(3872) as a hadronic molecule with a negative parity

Properties of X(3872) are studied by regarding it as a $DD^{\ast}$ hadronic molecule with $J^{PC} = 2^{-+}$ in the phenomenological Lagrangian approach. We find that our model with about 97.6% isospin zero component explains the existing data nicely, for example, the ratio $\mathcal{B}(X(3872) \to J/\psi\pi^+\pi^-\pi^0)/\mathcal{B}(X(3872) \to J/\psi\pi^+\pi^-)$. We predict the partial widths of the radiative decays of $X(3872) \to \gamma J/\psi$, $\gamma \psi(2S)$ and the strong decays of $X(3872) \to J/\psi \pi^+ \pi^-$, $J/\psi \pi^+\pi^-\pi^0$ as well as $X(3872) \to \chi_{cJ}\pi^0$. Our analysis shows that the measurement of the ratio $\mathcal{B}(X(3872) \to \chi_{c0}\pi^0)/\mathcal{B}(X(3872) \to \chi_{c1}\pi^0)$ may signal the nature of X(3872)

Genetic Covariance Structure of Reading, Intelligence and Memory in Children

This study investigates the genetic relationship among reading performance, IQ, verbal and visuospatial working memory (WM) and short-term memory (STM) in a sample of 112, 9-year-old twin pairs and their older siblings. The relationship between reading performance and the other traits was explained by a common genetic factor for reading performance, IQ, WM and STM and a genetic factor that only influenced reading performance and verbal memory. Genetic variation explained 83% of the variation in reading performance; most of this genetic variance was explained by variation in IQ and memory performance. We hypothesize, based on these results, that children with reading problems possibly can be divided into three groups: (1) children low in IQ and with reading problems; (2) children with average IQ but a STM deficit and with reading problems; (3) children with low IQ and STM deficits; this group may experience more reading problems than the other two

Large-scale latitudinal and vertical distributions of NMHCs and selected halocarbons in the troposphere over the Pacific Ocean during the March-April 1999 Pacific Exploratory Mission (PEM-Tropics B)

Nonmethane hydrocarbons (NMHCs) and selected halocarbons were measured in whole air samples collected over the remote Pacific Ocean during NASA's Global Tropospheric Experiment (GTE) Pacific Exploratory Mission-Tropics B (PEM-Tropics B) in March and early April 1999. The large-scale spatial distributions of NMHCs and C2Cl4 reveal a much more pronounced north-south interhemispheric gradient, with higher concentrations in the north and lower levels in the south, than for the late August to early October 1996 PEM-Tropics A experiment. Strong continental outflow and winter-long accumulation of pollutants led to seasonally high Northern Hemisphere trace gas levels during PEM-Tropics B. Observations of enhanced levels of Halon 1211 (from developing Asian nations such as the PRC) and CH3Cl (from SE Asian biomass burning) support a significant southern Asian influence at altitudes above 1 km and north of 10° N. By contrast, at low altitude over the North Pacific the dominance of urban/industrial tracers, combined with low levels of Halon 1211 and CH3Cl, indicate a greater influence from developed nations such as Japan, Europe, and North America. Penetration of air exhibiting aged northern hemisphere characteristics was frequently observed at low altitudes over the equatorial central and western Pacific south to ∼5° S. The relative lack of southern hemisphere biomass burning sources and the westerly position of the South Pacific convergence zone contributed to significantly lower PEM-Tropics B mixing ratios of the NMHCs and CH3Cl south of 10° S compared to PEM-Tropics A. Therefore the trace gas composition of the South Pacific troposphere was considerably more representative of minimally polluted tropospheric conditions during PEM-Tropics B. Copyright 2001 by the American Geophysical Union

Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review

With a political debate about the potential risks and benefits of cannabis use as a backdrop, the wave of legalization and liberalization initiatives continues to spread. Four states (Colorado, Washington, Oregon, and Alaska) and the District of Columbia have passed laws that legalized cannabis for recreational use by adults, and 23 others plus the District of Columbia now regulate cannabis use for medical purposes. These policy changes could trigger a broad range of unintended consequences, with profound and lasting implications for the health and social systems in our country. Cannabis use is emerging as one among many interacting factors that can affect brain development and mental function. To inform the political discourse with scientific evidence, the literature was reviewed to identify what is known and not known about the effects of cannabis use on human behavior, including cognition, motivation, and psychosis

Rapid acceleration of electrons in the magnetosphere by fast-mode MHD waves

During major megnetic storms, enhanced flux of relativistic electrons in the inner magnetosphere have been observed to correleated with ULF waves. The enhancements can take place over a period of several hours. In order to account for such a rapid generation of relativistic electrons, we examine the mechanism of transit-time acceleration of electrons by low-frequency fast-mode MHD waves, here the assumed form of ULF waves. Calcaulations of the acceleration timescales in the model show that fast-mode waves in the Pc4 to Pc5 frequency range, with typically observed wave amplitudes 10--20 nT, can accelerate the seed electrons to energies of order MeV in a period of a few hours.Comment: 9 pages, 3 figures, Accepted to J. Geophys. Re

The Imperial IRAS-FSC Redshift Catalogue: luminosity functions, evolution and galaxy bias

We present the luminosity function and selection function of 60 micron galaxies selected from the Imperial IRAS-FSC Redshift Catalogue (IIFSCz). Three methods, including the 1/Vmax} and the parametric and non-parametric maximum likelihood estimator, are used and results agree well with each other. A density evolution proportional to (1+z)^3.4 or a luminosity evolution exp(1.7 t_L / \tau)$ where t_L is the look-back time is detected in the full sample in the redshift range [0.02, 0.1], consistent with previous analyses. Of the four infrared subpopulations, cirrus-type galaxies and M82-type starbursts show similar evolutionary trends, galaxies with significant AGN contributions show stronger positive evolution and Arp 220-type starbursts exhibit strong negative evolution. The dominant subpopulation changes from cirrus-type galaxies to M82-type starbursts at log (L_60 / L_Sun) ~ 10.3. In the second half of the paper, we derive the projected two-point spatial correlation function for galaxies of different infrared template type. The mean relative bias between cirrus-type galaxies and M82-type starbursts, which correspond to quiescent galaxies with optically thin interstellar dust and actively star-forming galaxies respectively, is calculated to be around 1.25. The relation between current star formation rate (SFR) in star-forming galaxies and environment is investigated by looking at the the dependence of clustering on infrared luminosity. We found that M82-type actively star-forming galaxies show stronger clustering as infrared luminosity / SFR increases. The correlation between clustering strength and SFR in the local Universe seems to echo the basic trend seen in star-forming galaxies in the Great Observatories Origins Deep Survey (GOODS) fields at z ~ 1.Comment: 15 pages, 11 figures, accepted for publication in MNRA

Oral chondroitin sulfate and prebiotics for the treatment of canine Inflammatory Bowel Disease: a randomized, controlled clinical trial

BACKGROUND Canine inflammatory bowel disease (IBD) is a chronic enteropathy of unknown etiology, although microbiome dysbiosis, genetic susceptibility, and dietary and/or environmental factors are hypothesized to be involved in its pathogenesis. Since some of the current therapies are associated with severe side effects, novel therapeutic modalities are needed. A new oral supplement for long-term management of canine IBD containing chondroitin sulfate (CS) and prebiotics (resistant starch, β-glucans and mannaoligosaccharides) was developed to target intestinal inflammation and oxidative stress, and restore normobiosis, without exhibiting any side effects. This double-blinded, randomized, placebo-controlled trial in dogs with IBD aims to evaluate the effects of 180 days administration of this supplement together with a hydrolyzed diet on clinical signs, intestinal histology, gut microbiota, and serum biomarkers of inflammation and oxidative stress. RESULTS Twenty-seven client-owned biopsy-confirmed IBD dogs were included in the study, switched to the same hydrolyzed diet and classified into one of two groups: supplement and placebo. Initially, there were no significant differences between groups (p > 0.05) for any of the studied parameters. Final data analysis (supplement: n = 9; placebo: n = 10) showed a significant decrease in canine IBD activity index (CIBDAI) score in both groups after treatment (p < 0.001). After treatment, a significant decrease (1.53-fold; p < 0.01) in histologic score was seen only in the supplement group. When groups were compared, the supplement group showed significantly higher serum cholesterol (p < 0.05) and paraoxonase-1 (PON1) levels after 60 days of treatment (p < 0.01), and the placebo group showed significantly reduced serum total antioxidant capacity (TAC) levels after 120 days (p < 0.05). No significant differences were found between groups at any time point for CIBDAI, WSAVA histologic score and fecal microbiota evaluated by PCR-restriction fragment length polymorphism (PCR-RFLP). No side effects were reported in any group. CONCLUSIONS The combined administration of the supplement with hydrolyzed diet over 180 days was safe and induced improvements in selected serum biomarkers, possibly suggesting a reduction in disease activity. This study was likely underpowered, therefore larger studies are warranted in order to demonstrate a supplemental effect to dietary treatment of this supplement on intestinal histology and CIBDAI

Simultaneous measurement of cosmology and intrinsic alignments using joint cosmic shear and galaxy number density correlations

Cosmic shear is a powerful method to constrain cosmology, provided that any systematic effects are under control. The intrinsic alignment of galaxies is expected to severely bias parameter estimates if not taken into account. We explore the potential of a joint analysis of tomographic galaxy ellipticity, galaxy number density, and ellipticity-number density cross-correlations to simultaneously constrain cosmology and self-calibrate unknown intrinsic alignment and galaxy bias contributions. We treat intrinsic alignments and galaxy biasing as free functions of scale and redshift and marginalise over the resulting parameter sets. Constraints on cosmology are calculated by combining the likelihoods from all two-point correlations between galaxy ellipticity and galaxy number density. The information required for these calculations is already available in a standard cosmic shear dataset. We include contributions to these functions from cosmic shear, intrinsic alignments, galaxy clustering and magnification effects. In a Fisher matrix analysis we compare our constraints with those from cosmic shear alone in the absence of intrinsic alignments. For a potential future large area survey, such as Euclid, the extra information from the additional correlation functions can make up for the additional free parameters in the intrinsic alignment and galaxy bias terms, depending on the flexibility in the models. For example, the Dark Energy Task Force figure of merit is recovered even when more than 100 free parameters are marginalised over. We find that the redshift quality requirements are similar to those calculated in the absence of intrinsic alignments.Comment: 22 pages, 10 figures; extended discussion, otherwise minor changes to match accepted version; published in Astronomy and Astrophysic

Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour

The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most frequently described mechanism acts through attractants causing actin polymerization, in turn leading to pseudopod formation and cell movement. We recently proposed an alternative mechanism, supported by several lines of data, in which pseudopods are made by a self-generated cycle. If chemoattractants are present, they modulate the cycle rather than directly causing actin polymerization. The aim of this work is to test the explanatory and predictive powers of such pseudopod-based models to predict the complex behaviour of cells in chemotaxis. We have now tested the effectiveness of this mechanism using a computational model of cell movement and chemotaxis based on pseudopod autocatalysis. The model reproduces a surprisingly wide range of existing data about cell movement and chemotaxis. It simulates cell polarization and persistence without stimuli and selection of accurate pseudopods when chemoattractant gradients are present. It predicts both bias of pseudopod position in low chemoattractant gradients and-unexpectedly-lateral pseudopod initiation in high gradients. To test the predictive ability of the model, we looked for untested and novel predictions. One prediction from the model is that the angle between successive pseudopods at the front of the cell will increase in proportion to the difference between the cell's direction and the direction of the gradient. We measured the angles between pseudopods in chemotaxing Dictyostelium cells under different conditions and found the results agreed with the model extremely well. Our model and data together suggest that in rapidly moving cells like Dictyostelium and neutrophils an intrinsic pseudopod cycle lies at the heart of cell motility. This implies that the mechanism behind chemotaxis relies on modification of intrinsic pseudopod behaviour, more than generation of new pseudopods or actin polymerization by chemoattractant