A Search for Photometric Variability in L and T type Brown Dwarf Atmospheres

Using the Gemini infrared camera on the 3-meter Shane telescope at Lick Observatory, we have searched for broad-band J and K' photometric variability for a sample of 15 L and T-type brown dwarfs, including 7 suspected spectral binaries. Four of the dwarfs - 2MASS J0939-2448, 2MASS J1416+1348A, 2MASS J1711+2232, and 2MASS J2139+0220 - exhibit statistically significant variations over timescales ranging from ~0.5 hr to 6 days. Our detection of variability in 2MASS J2139+0220 confirms that reported by Radigan et al., and periodogram and phase dispersion minimization analysis also confirms a variability period of approximately 7.6 +/- 0.2 hours. Remarkably, two of the four variables are known or candidate binary systems, including 2MASS J2139+0220, for which we find only marginal evidence of radial velocity variation over the course of a year. This result suggests that some spectral binary candidates may appear as such due to the blending of cloudy and non-cloudy regions in a single "patchy" atmosphere. Our results are consistent with an overall variability fraction of 35 +/- 5 %, with no clear evidence of greater variability among brown dwarfs at the L dwarf/T dwarf transition

A submillimetre survey of the kinematics of the Perseus molecular cloud - III. Clump kinematics

We explore the kinematics of continuum clumps in the Perseus molecular cloud, derived from C18O J=3-2 data. Two populations are examined, identified using the automated algorithms CLFIND and GAUSSCLUMPS on existing SCUBA data. The clumps have supersonic linewidths with distributions which suggest the C18O line probes a lower-density 'envelope' rather than a dense inner core. Similar linewidth distributions for protostellar and starless clumps implies protostars do not have a significant impact on their immediate environment. The proximity to an active young stellar cluster seems to affect the linewidths: those in NGC1333 are greater than elsewhere. In IC348 the proximity to the old IR cluster has little influence, with the linewidths being the smallest of all. A virial analysis suggests that the clumps are bound and close to equipartition. In particular, the starless clumps occupy the same parameter space as the protostars, suggesting they are true stellar precursors and will go on to form stars. We also search for ordered C18O velocity gradients across the face of each core, usually interpreted as rotation. We note a correlation between the directions of the identified gradients and outflows across protostars, indicating we may not have a purely rotational signature. The fitted gradients are larger than found in previous work, probably as a result of the higher resolution of our data and/or outflow contamination. These gradients, if interpreted solely in terms of rotation, suggest that rotation is not dynamically significant. Furthermore, derived specific angular momenta are smaller than observed in previous studies, centred around j~0.001 km/s pc, which indicates we have identified lower levels of rotation, or that the C18O J=3-2 line probes conditions significantly denser and/or colder than n~10^5 per cc and T~10 K.Comment: 20 pages, 20 figures, accepted for publication by MNRAS. Supplementary, on-line only material available from http://www.mrao.cam.ac.uk/~eic22/Papers/CR10b_suppmaterial.pd

The properties of SCUBA cores in the Perseus molecular cloud: the bias of clump-finding algorithms

We present a new analysis of the properties of star-forming cores in the Perseus molecular cloud, identified in SCUBA 850 micron data. Our goal is to determine which core properties can be robustly identified and which depend on the extraction technique. Four regions in the cloud are examined: NGC1333, IC348/HH211, L1448 and L1455. We identify clumps of dust emission using two popular automated algorithms, CLFIND and GAUSSCLUMPS, finding 85 and 122 clumps in total respectively. Some trends are true for both populations: clumps become increasingly elongated over time and are consistent with constant surface brightness objects, with an average brightness ~4 to 10 times larger than the surrounding molecular cloud; the clump mass distribution (CMD) resembles the stellar intial mass function, with a slope alpha = -2.0+/-0.1 for CLFIND and alpha = -3.15+/-0.08 for GAUSSCLUMPS, which straddle the Salpeter value. The mass at which the slope shallows (similar for both algorithms at M~6 Msun) implies a star-forming efficiency of between 10 and 20 per cent. Other trends reported elsewhere depend on the clump-finding technique: we find protostellar clumps are both smaller (for GAUSSCLUMPS) and larger (for CLFIND) than their starless counterparts; the functional form, best-fitting to the CMD, is different for the two algorithms. The GAUSSCLUMPS CMD is best-fitted with a log-normal distribution, whereas a broken power law is best for CLFIND; the reported lack of massive starless cores in previous studies can be seen in the CLFIND but not the GAUSSCLUMPS data. Our approach highlights similarities and differences between the clump populations, illustrating the caution that must be exercised when comparing results from different studies and interpreting the properties of continuum cores.Comment: 19 pages, 17 figures, accepted for publication by MNRA

Berkeley Supernova Ia Program I: Observations, Data Reduction, and Spectroscopic Sample of 582 Low-Redshift Type Ia Supernovae

In this first paper in a series we present 1298 low-redshift (z\leq0.2) optical spectra of 582 Type Ia supernovae (SNe Ia) observed from 1989 through 2008 as part of the Berkeley SN Ia Program (BSNIP). 584 spectra of 199 SNe Ia have well-calibrated light curves with measured distance moduli, and many of the spectra have been corrected for host-galaxy contamination. Most of the data were obtained using the Kast double spectrograph mounted on the Shane 3 m telescope at Lick Observatory and have a typical wavelength range of 3300-10,400 Ang., roughly twice as wide as spectra from most previously published datasets. We present our observing and reduction procedures, and we describe the resulting SN Database (SNDB), which will be an online, public, searchable database containing all of our fully reduced spectra and companion photometry. In addition, we discuss our spectral classification scheme (using the SuperNova IDentification code, SNID; Blondin & Tonry 2007), utilising our newly constructed set of SNID spectral templates. These templates allow us to accurately classify our entire dataset, and by doing so we are able to reclassify a handful of objects as bona fide SNe Ia and a few other objects as members of some of the peculiar SN Ia subtypes. In fact, our dataset includes spectra of nearly 90 spectroscopically peculiar SNe Ia. We also present spectroscopic host-galaxy redshifts of some SNe Ia where these values were previously unknown. [Abridged]Comment: 34 pages, 11 figures, 11 tables, revised version, re-submitted to MNRAS. Spectra will be released in January 2013. The SN Database homepage (http://hercules.berkeley.edu/database/index_public.html) contains the full tables, plots of all spectra, and our new SNID template

Fluorescence spectroscopy analysis of the bacteria-mineral interface: adsorption of lipopolysaccharides to silica and alumina

YesWe present here a quantification of the sorption process and molecular conformation involved in the attachment of bacterial cell wall lipopolysaccharides (LPSs), extracted from Escherichia coli, to silica (SiO2) and alumina (Al2O3) particles. We propose that interfacial forces govern the physicochemical interactions of the bacterial cell wall with minerals in the natural environment, and the molecular conformation of LPS cell wall components depends on both the local charge at the point of binding and hydrogen bonding potential. This has an effect on bacterial adaptation to the host environment through adhesion, growth, function, and ability to form biofilms. Photophysical techniques were used to investigate adsorption of fluorescently labeled LPS onto mineral surfaces as model systems for bacterial attachment. Adsorption of macromolecules in dilute solutions was studied as a function of pH and ionic strength in the presence of alumina and silica via fluorescence, potentiometric, and mass spectrometry techniques. The effect of silica and alumina particles on bacterial growth as a function of pH was also investigated using spectrophotometry. The alumina and silica particles were used to mimic active sites on the surface of clay and soil particles, which serve as a point of attachment of bacteria in natural systems. It was found that LPS had a high adsorption affinity for Al2O3 while adsorbing weakly to SiO2 surfaces. Strong adsorption was observed at low pH for both minerals and varied with both pH and mineral concentration, likely in part due to conformational rearrangement of the LPS macromolecules. Bacterial growth was also enhanced in the presence of the particles at low pH values. This demonstrates that at a molecular level, bacterial cell wall components are able to adapt their conformation, depending on the solution pH, in order to maximize attachment to substrates and guarantee community survival.The authors thank the Libyan Ministry of Education for financial support during the experimental study. We thank the EPSRC funded consortium “Hard-soft matter interfaces: from understanding to engineering” (EP/I001514/1) for financial support. Emily Caseley, who assisted in the preparation and characterization of AmNS-LPS particles as an MRC Confidence in Concept funded postdoctoral researcher at the University of Bradford, (MC_PC_16038)

Research Personnel Exposure to Carbon Dioxide During Euthanasia Procedures

Carbon dioxide (CO2) is a commonly used euthanasia agent in animal facilities. This procedure is carried out by replacing oxygen with carbon dioxide in animal cages, thus providing a quick and painless method of euthanasia. Unfortunately, there has been limited research on the potential effects of human exposure to CO2 during euthanasia procedures. Following a previous carbon dioxide exposure study in the vivarium at Rowan SOM in 2016, the CO2 cylinders and euthanasia chambers have been relocated to room 153 Science Center and the vivarium has adopted a localized exhaust that helps remove the contaminant at the source. While the results from the 2016 study were within the Occupational Health and Safety (OSHA) and American Conference of Governmental Industrial Hygienist (ACGIH) carbon dioxide exposure limits, the research team replicated the study to ensure compliance at the new euthanasia chamber location

Near infrared spectroscopic measurement of strain in rocks

The measurement of strain is a fundamental and widely studied parameter in engineering, rock mechanics, construction and materials testing. Contact sensors often used in these fields require contact with the target surface throughout the duration of a strain event. Non-contact methods typically require that that the measurement surface is prepared and often coated prior to testing. This paper considers the potential application of near infrared spectroscopy as a non-contact technique for the measurement of strain on natural surfaces. Excellent correlation was found between surface measurements of visible-NIR spectra and longitudinal strain taken during indirect Brazilian Disc Test for samples of sandstone, marble and basalt

Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension.

BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare disease with an emerging genetic basis. Heterozygous mutations in the gene encoding the bone morphogenetic protein receptor type 2 (BMPR2) are the commonest genetic cause of PAH, whereas biallelic mutations in the eukaryotic translation initiation factor 2 alpha kinase 4 gene (EIF2AK4) are described in pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis. Here, we determine the frequency of these mutations and define the genotype-phenotype characteristics in a large cohort of patients diagnosed clinically with PAH. METHODS: Whole-genome sequencing was performed on DNA from patients with idiopathic and heritable PAH and with pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis recruited to the National Institute of Health Research BioResource-Rare Diseases study. Heterozygous variants in BMPR2 and biallelic EIF2AK4 variants with a minor allele frequency of <1:10 000 in control data sets and predicted to be deleterious (by combined annotation-dependent depletion, PolyPhen-2, and sorting intolerant from tolerant predictions) were identified as potentially causal. Phenotype data from the time of diagnosis were also captured. RESULTS: Eight hundred sixty-four patients with idiopathic or heritable PAH and 16 with pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis were recruited. Mutations in BMPR2 were identified in 130 patients (14.8%). Biallelic mutations in EIF2AK4 were identified in 5 patients with a clinical diagnosis of pulmonary veno-occlusive disease/pulmonary capillary hemangiomatosis. Furthermore, 9 patients with a clinical diagnosis of PAH carried biallelic EIF2AK4 mutations. These patients had a reduced transfer coefficient for carbon monoxide (Kco; 33% [interquartile range, 30%-35%] predicted) and younger age at diagnosis (29 years; interquartile range, 23-38 years) and more interlobular septal thickening and mediastinal lymphadenopathy on computed tomography of the chest compared with patients with PAH without EIF2AK4 mutations. However, radiological assessment alone could not accurately identify biallelic EIF2AK4 mutation carriers. Patients with PAH with biallelic EIF2AK4 mutations had a shorter survival. CONCLUSIONS: Biallelic EIF2AK4 mutations are found in patients classified clinically as having idiopathic and heritable PAH. These patients cannot be identified reliably by computed tomography, but a low Kco and a young age at diagnosis suggests the underlying molecular diagnosis. Genetic testing can identify these misclassified patients, allowing appropriate management and early referral for lung transplantation

The effect of breaking sitting time with physical activity breaks on cognitive performance in young people with cerebral palsy: an exposure response cross-over feasibility design

Objectives: To assess the feasibility of methods and estimate the potential effect of interrupting sedentary behaviour, with intermittent or continuous physical activity breaks, on cognitive performance in young people with Cerebral Palsy. Methods: A randomised three-arm exposure response cross-over design with process evaluation. Participants were recruited throughout the Thames Valley, UK between 01/11/2018 to 31/03/2020. The three 2 h activity exposure visits included: (i) sitting only (controls), (ii) sitting plus 20 min of moderate-to-vigorous activity burst, or (iii) 4×5 min of moderate-to-vigorous activity bursts, during a 2.5 h sedentary session. Measures of feasibility were sought. Cognitive performance outcomes (using the Eriksen Flanker task and Forward and Backward Digit Span) were delivered before and after the 2 h testing period. Results: 36 participants were randomised (age 13.2±2.7, Gross-Motor Functional Classification System 1–3). Study retention was 83 % across all three interventions and overall missing data for measures was 4 %. A small intervention effect was found in reaction time in the 4×5 min physical activity exposure session compared to the sedentary control condition (0.42; 95 % CI 0.40 to 0.79). There were two research-related minor adverse effects, an allergic reaction to the FreeStyle Libre and feeling faint and vomiting after consumption of glucose solution. Both events were resolved and participants continued with the study. Conclusions: The study design and intervention implementing short bursts of physical activity was feasible and indicated a potential effect on reaction time as a measure of cognitive performance in young people with cerebral palsy

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements