Paradigmaváltás a csontmetasztázisok sebészetében. I. Végtagi és medencelokalizációjú áttétek

According to the statistical data of tumor registries the incidence of cancer has increased in the last decade, however the mortality shows only a slight change due to the new and effective multimodal treatments. The aim of our overview article is to present the changes in the survival of the metastatic patients, and to demonstrate which factors influence their prognosis. The improvement of survival resulted in a more active surgical role both in metastases of the bone of the extremities and the pelvis. We present a diagnostic flow chart and current options for the reconstruction of the different regions of the bone and skeleton, and we will discuss their potential advantages, disadvantages and complications. It is evident that apart from the impending and pathological fracture surgery it is not the first choice of treatment but rather a palliative measure. The aim of surgery is to alleviate pain, to regain mobility and improve quality of life. If possible minimal invasive techniques are performed, as they are less demanding and allow fast rehabilitation for the patient, and they are solutions that last for a lifetime. In optimal conditions radical curative surgery can be performed in about 10 to 15 per cent of the cases, and better survival is encouraging. Orv Hetil. 2017; 158(40): 1563-1569

Wall-crossing, open BPS counting and matrix models

We consider wall-crossing phenomena associated to the counting of D2-branes attached to D4-branes wrapping lagrangian cycles in Calabi-Yau manifolds, both from M-theory and matrix model perspective. Firstly, from M-theory viewpoint, we review that open BPS generating functions in various chambers are given by a restriction of the modulus square of the open topological string partition functions. Secondly, we show that these BPS generating functions can be identified with integrands of matrix models, which naturally arise in the free fermion formulation of corresponding crystal models. A parameter specifying a choice of an open BPS chamber has a natural, geometric interpretation in the crystal model. These results extend previously known relations between open topological string amplitudes and matrix models to include chamber dependence.Comment: 25 pages, 8 figures, published versio

Wall-crossing, free fermions and crystal melting

We describe wall-crossing for local, toric Calabi-Yau manifolds without compact four-cycles, in terms of free fermions, vertex operators, and crystal melting. Firstly, to each such manifold we associate two states in the free fermion Hilbert space. The overlap of these states reproduces the BPS partition function corresponding to the non-commutative Donaldson-Thomas invariants, given by the modulus square of the topological string partition function. Secondly, we introduce the wall-crossing operators which represent crossing the walls of marginal stability associated to changes of the B-field through each two-cycle in the manifold. BPS partition functions in non-trivial chambers are given by the expectation values of these operators. Thirdly, we discuss crystal interpretation of such correlators for this whole class of manifolds. We describe evolution of these crystals upon a change of the moduli, and find crystal interpretation of the flop transition and the DT/PT transition. The crystals which we find generalize and unify various other Calabi-Yau crystal models which appeared in literature in recent years.Comment: 61 pages, 14 figures, published versio

Multiple D4-D2-D0 on the Conifold and Wall-crossing with the Flop

We study the wall-crossing phenomena of D4-D2-D0 bound states with two units of D4-brane charge on the resolved conifold. We identify the walls of marginal stability and evaluate the discrete changes of the BPS indices by using the Kontsevich-Soibelman wall-crossing formula. In particular, we find that the field theories on D4-branes in two large radius limits are properly connected by the wall-crossings involving the flop transition of the conifold. We also find that in one of the large radius limits there are stable bound states of two D4-D2-D0 fragments.Comment: 24 pages, 4 figures; v2: typos corrected, minor changes, a reference adde

Wall-crossing of D4-D2-D0 and flop of the conifold

We discuss the wall-crossing of the BPS bound states of a non-compact holomorphic D4-brane with D2 and D0-branes on the conifold. We use the Kontsevich-Soibelman wall-crossing formula and analyze the BPS degeneracy in various chambers. In particular we obtain a relation between BPS degeneracies in two limiting attractor chambers related by a flop transition. Our result is consistent with known results and predicts BPS degeneracies in all chambers.Comment: 15 pages, 4 figures; v2: typos corrected; v3: minor changes, a reference added, version to be published in JHE

Quivers, YBE and 3-manifolds

We study 4d superconformal indices for a large class of N=1 superconformal quiver gauge theories realized combinatorially as a bipartite graph or a set of "zig-zag paths" on a two-dimensional torus T^2. An exchange of loops, which we call a "double Yang-Baxter move", gives the Seiberg duality of the gauge theory, and the invariance of the index under the duality is translated into the Yang-Baxter-type equation of a spin system defined on a "Z-invariant" lattice on T^2. When we compactify the gauge theory to 3d, Higgs the theory and then compactify further to 2d, the superconformal index reduces to an integral of quantum/classical dilogarithm functions. The saddle point of this integral unexpectedly reproduces the hyperbolic volume of a hyperbolic 3-manifold. The 3-manifold is obtained by gluing hyperbolic ideal polyhedra in H^3, each of which could be thought of as a 3d lift of the faces of the 2d bipartite graph.The same quantity is also related with the thermodynamic limit of the BPS partition function, or equivalently the genus 0 topological string partition function, on a toric Calabi-Yau manifold dual to quiver gauge theories. We also comment on brane realization of our theories. This paper is a companion to another paper summarizing the results.Comment: 61 pages, 16 figures; v2: typos correcte

Wall Crossing, Quivers and Crystals

We study the spectrum of BPS D-branes on a Calabi-Yau manifold using the 0+1 dimensional quiver gauge theory that describes the dynamics of the branes at low energies. The results of Kontsevich and Soibelman predict how the degeneracies change. We argue that Seiberg dualities of the quiver gauge theories, which change the basis of BPS states, correspond to crossing the "walls of the second kind." There is a large class of examples, including local del Pezzo surfaces, where the BPS degeneracies of quivers corresponding to one D6 brane bound to arbitrary numbers of D4, D2 and D0 branes are counted by melting crystal configurations. We show that the melting crystals that arise are a discretization of the Calabi-Yau geometry. The shape of the crystal is determined by the Calabi-Yau geometry and the background B-field, and its microscopic structure by the quiver Q. We prove that the BPS degeneracies computed from Q and Q' are related by the Kontsevich Soibelman formula, using a geometric realization of the Seiberg duality in the crystal. We also show that, in the limit of infinite B-field, the combinatorics of crystals arising from the quivers becomes that of the topological vertex. We thus re-derive the Gromov-Witten/Donaldson-Thomas correspondence

Simulation of an SEIR infectious disease model on the dynamic contact network of conference attendees

The spread of infectious diseases crucially depends on the pattern of contacts among individuals. Knowledge of these patterns is thus essential to inform models and computational efforts. Few empirical studies are however available that provide estimates of the number and duration of contacts among social groups. Moreover, their space and time resolution are limited, so that data is not explicit at the person-to-person level, and the dynamical aspect of the contacts is disregarded. Here, we want to assess the role of data-driven dynamic contact patterns among individuals, and in particular of their temporal aspects, in shaping the spread of a simulated epidemic in the population. We consider high resolution data of face-to-face interactions between the attendees of a conference, obtained from the deployment of an infrastructure based on Radio Frequency Identification (RFID) devices that assess mutual face-to-face proximity. The spread of epidemics along these interactions is simulated through an SEIR model, using both the dynamical network of contacts defined by the collected data, and two aggregated versions of such network, in order to assess the role of the data temporal aspects. We show that, on the timescales considered, an aggregated network taking into account the daily duration of contacts is a good approximation to the full resolution network, whereas a homogeneous representation which retains only the topology of the contact network fails in reproducing the size of the epidemic. These results have important implications in understanding the level of detail needed to correctly inform computational models for the study and management of real epidemics

Instanton Counting and Wall-Crossing for Orbifold Quivers

Noncommutative Donaldson-Thomas invariants for abelian orbifold singularities can be studied via the enumeration of instanton solutions in a six-dimensional noncommutative {Mathematical expression} gauge theory; this construction is based on the generalized McKay correspondence and identifies the instanton counting with the counting of framed representations of a quiver which is naturally associated with the geometry of the singularity. We extend these constructions to compute BPS partition functions for higher-rank refined and motivic noncommutative Donaldson-Thomas invariants in the Coulomb branch in terms of gauge theory variables and orbifold data. We introduce the notion of virtual instanton quiver associated with the natural symplectic charge lattice which governs the quantum wall-crossing behaviour of BPS states in this context. The McKay correspondence naturally connects our formalism with other approaches to wall-crossing based on quantum monodromy operators and cluster algebras

Evidence for Duality of Conifold from Fundamental String

We study the spectrum of BPS D5-D3-F1 states in type IIB theory, which are proposed to be dual to D4-D2-D0 states on the resolved conifold in type IIA theory. We evaluate the BPS partition functions for all values of the moduli parameter in the type IIB side, and find them completely agree with the results in the type IIA side which was obtained by using Kontsevich-Soibelman's wall-crossing formula. Our result is a quite strong evidence for string dualities on the conifold.Comment: 24 pages, 13 figures, v2: typos corrected, v3: explanations about wall-crossing improved and figures adde