Synthesis and antibacterial effects of cobalt–cellulose magnetic nanocomposites

© The Royal Society of Chemistry. Green synthesis is employed to prepare cobalt/cellulose nanocomposites with cubic (α-cobalt) cobalt as a main component with antibacterial and magnetic properties. An in situ reduction of aqueous solutions of cobalt ions on a model cellulose substrate surface using hydrogen gas affords spherical, cellulose-stabilised cobalt nanoclusters with magnetic properties and an average diameter of 7 nm that are distributed evenly over the surface of the cellulose fibres. These cobalt/cellulose nanocomposites exhibit good antibacterial action against opportunistic pathogens both Gram-positive (S. aureus) and Gram-negative (E. coli, A. baumannii and P. aeruginosa), with zones of inhibition up to 15 mm, thereby encouraging the deployment of these advanced materials for the treatment of wastewater or within medical dressings. This method of preparation is compared with the analogous in situ reduction of cobalt ions on a cellulose surface using sodium borohydride as reducing agent

Energy Efficient Resource Allocation in Vehicular Cloud based Architecture

The increasing availability of on-board processing units in vehicles has led to a new promising mobile edge computing (MEC) concept which integrates desirable features of clouds and VANETs under the concept of vehicular clouds (VC). In this paper we propose an architecture that integrates VC with metro fog nodes and the central cloud to ensure service continuity. We tackle the problem of energy efficient resource allocation in this architecture by developing a Mixed Integer Linear Programming (MILP) model to minimize power consumption by optimizing the assignment of different tasks to the available resources in this architecture. We study service provisioning considering different assignment strategies under varying application demands and analyze the impact of these strategies on the utilization of the VC resources and therefore, the overall power consumption. The results show that traffic demands have a higher impact on the power consumption, compared to the impact of the processing demands. Integrating metro fog nodes and vehicle edge nodes in the cloud-based architecture can save power, with an average power saving up to 54%. The power savings can increase by 12% by distributing the task assignment among multiple vehicles in the VC level, compared to assigning the whole task to a single processing node

Synthesis and antimicrobial effects of highly dispersed, cellulose-stabilized silver/cellulose nanocomposites

Small, spherical silver nanoclusters were synthesised on the surface of paper as a model cellulosic fibre substrate by a standard chemical reduction method. The concentration of the silver nanoclusters on the substrate surface is roughly proportional to the initial silver salt concentration. However, there is a noticeable degree of nanocluster aggregation to larger agglomerates. The addition of small amounts of α-cellulose, carboxymethyl cellulose or aminocellulose during the synthesis of the silver/cellulose nanocomposites suppresses this aggregation and significantly increases the concentration of the silver nanoclusters on the surface of the fibres of cellulose. These small, surface-stabilised silver nanoclusters, with the desired size and morphology, deposited from aqueous solutions on the surface of cellulosic cotton fibres, show enhanced antibacterial activity against MRSA compared to that of the corresponding silver/cotton nanocomposites prepared in the absence of a cellulosic surface stabiliser

A sustainability assessment of the modern method of construction in Saudi Arabia

By 2030, the Kingdom of Saudi Arabia (KSA) is seeking to increase homeownership to 70%. This has led to a considerable investment in residential construction, with the Housing Ministry establishing a stimulus program to enhance the use of Modern Methods of Construction (MMC). These technologies offer several benefits, including cost and time reduction, improved quality and productivity, and job creation. This study quantitatively analyzes the economic impacts of MMC adaptation on the Saudi economy using the Global Trade Analysis Project (GTAP) model. It considers incentives to adopt MMC, its technological advancements, and the skills currently available in the Saudi labor market. Moreover, the embodied carbon emissions of MMC are calculated using the Input–Output Life Cycle Assessment Approach (IO-LCA); the detailed environmental emissions from the transportation phase, accounting for material reduction, are assessed using the COPERT model and compared to conventional construction. The results reveal an increase of 1.92% in Saudi GDP, along with improved welfare of $28.5 billion and a notable increase in the sectors related to construction. Job creation is demonstrated by an increase in the employment of unskilled and skilled labor by 2.02 and 1.5%, respectively. The paper concludes that MMC’s total embodied carbon emissions were approximately 77 million metric tonnes CO2, while its transport-related emissions are less than conventional approaches

NGAL is downregulated in oral squamous cell carcinoma and leads to increased survival, proliferation, migration and chemoresistance

Oral cancer is a major public health burden worldwide. The lack of biomarkers for early diagnosis has increased the difficulty in managing this disease. Recent studies have reported that neutrophil gelatinase-associated lipocalin (NGAL), a secreted glycoprotein, is upregulated in various tumors. In our study, we found that NGAL was significantly downregulated in primary malignant and metastatic tissues of oral cancer in comparison to normal tissues. The downregulation of NGAL was strongly correlated with both degree of differentiation and stage (I–IV); it can also serve as a prognostic biomarker for oral cancer. Additionally, tobacco carcinogens were found to be involved in the downregulation of NGAL. Mechanistic studies revealed that knockdown of NGAL increased oral cancer cell proliferation, survival, and migration; it also induced resistance against cisplatin. Silencing of NGAL activated mammalian target of rapamycin (mTOR)signaling and reduced autophagy by the liver kinase B1 (LKB1)-activated protein kinase (AMPK)-p53-Redd1 signaling axis. Moreover, cyclin-D1, Bcl-2, and matrix metalloproteinase-9 (MMP-9) were upregulated, and caspase-9 was downregulated, suggesting that silencing of NGAL increases oral cancer cell proliferation, survival, and migration. Thus, from our study, it is evident that downregulation of NGAL activates the mTOR pathway and helps in the progression of oral cancer