1,155 research outputs found

    Used papermaking properties of pulp the compositions of the printing paper

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    The article presents a study of two kinds of papermaking pulp properties, that is thermomechanical and chemi-thermomechanical. Optimal parameters ofgrinding chemical-thermo-mechanical pulp were defined. Influence of pulp on the structural, mechanical and optical properties of paper samples was studied for offset printing. It has been established that the use of wood pulp in composition does not adversely affect on the structural, mechanical, optical and printing properties of paper

    Kinetics of fragmentation and dissociation of two-strand protein filaments: Coarse-grained simulations and experiments.

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    While a significant body of investigations have been focused on the process of protein self-assembly, much less is understood about the reverse process of a filament breaking due to thermal motion into smaller fragments, or depolymerization of subunits from the filament ends. Indirect evidence for actin and amyloid filament fragmentation has been reported, although the phenomenon has never been directly observed either experimentally or in simulations. Here we report the direct observation of filament depolymerization and breakup in a minimal, calibrated model of coarse-grained molecular simulation. We quantify the orders of magnitude by which the depolymerization rate from the filament ends koff is larger than fragmentation rate k- and establish the law koff/k- = exp[(ε‖ - ε⊥)/kBT] = exp[0.5ε/kBT], which accounts for the topology and energy of bonds holding the filament together. This mechanism and the order-of-magnitude predictions are well supported by direct experimental measurements of depolymerization of insulin amyloid filaments.This research was supported by the ERC, EPSRC, BBSRC, and the Newman Foundation.This is the author accepted manuscript. The final version is available from the American Institute of Physics via http://dx.doi.org/10.1063/1.496236

    Spinning and rotating strings for N=1 SYM theory and brane constructions

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    We obtain spinning and rotating closed string solutions in AdS_5 \times T^{1,1} background, and show how these solutions can be mapped onto rotating closed strings embedded in configurations of intersecting branes in type IIA string theory. Then, we discuss spinning closed string solutions in the UV limit of the Klebanov-Tseytlin background, and also properties of classical solutions in the related intersecting brane constructions in the UV limit. We comment on extensions of this analysis to the deformed conifold background, and in the corresponding intersecting brane construction, as well as its relation to the deep IR limit of the Klebanov-Strassler solution. We briefly discuss on the relation between type IIA brane constructions and their related M-theory descriptions, and how solitonic solutions are related in both descriptions.Comment: 35 pages. Dedicated to the memory of Ian I. Kogan. References adde

    New advances in Raman study of polyvinylchloride structure

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    In this work we investigated Raman spectra of a number of industrial grades of polyvinylchloride powder and films, prepared from solutions in tetrahydrofuran and acetophenone. The number and spectral characteristics of the Raman lines in the spectral regions of the C-Cl stretching vibrations and in the region of the C-H and CH2 stretching vibrations were evaluated

    Adult weight gain and colorectal adenomas – a systematic review and meta-analysis

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    Background: Colorectal adenomas are known as precursors for the majority of colorectal carcinomas. While weight gain during adulthood has been identified as a risk factor for colorectal cancer, the association is less clear for colorectal adenomas. We conducted a systematic review and meta-analysis to quantify the evidence on this association. Methods: We searched MEDLINE up to September 2016 to identify observational (prospective, cross-sectional and retrospective) studies on weight gain during adulthood and colorectal adenoma occurrence and recurrence. We conducted meta-analysis on high weight gain versus stable weight, linear and non-linear dose-response meta-analyses to analyze the association. Summary odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using a random effects model. Results: For colorectal adenoma occurrence, the summary OR was 1.39 (95% CI: 1.17-1.65; I2 :43%, N =9 studies, cases=5,507) comparing high (midpoint: 17.4 kg) versus stable weight gain during adulthood and with each 5 kg weight gain the odds increased by 7% (2%-11%; I2 :65%, N=7 studies). Although there was indication of non-linearity (Pnon-linearity <0.001) there was an increased odds of colorectal adenoma throughout the whole range of weight gain. Three studies were identified investigating the association between weight gain and colorectal adenoma recurrence and data were limited to draw firm conclusions. Conclusions: Even a small amount of adult weight gain was related to a higher odds of colorectal adenoma occurrence. Our findings add to the benefits of weight control in adulthood regarding colorectal adenomas occurrence, which might be relevant for early prevention of colorectal cancer

    Influence of obesity and related metabolic alterations on colorectal cancer risk

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    Obesity and related metabolic alterations have been implicated to play a role in colorectal cancer risk. The metabolic syndrome, as assessed according to current international definitions by the key components, abdominal obesity, dyslipidemia, elevated blood pressure, and abnormal glucose metabolism, is associated with colorectal cancer. Recent studies suggest that abdominal obesity and abnormal glucose metabolism may primarily account for this association. Visceral adipose tissue is physiologically more active than subcutaneous adipose tissue and generates hormones and cytokines with inflammatory, metabolic, and direct carcinogenic potential, which may directly or indirectly increase colorectal cancer risk. Current evidence suggests that obesity acts as a risk factor for colorectal cancer by several mechanisms, including chronic low-grade inflammation, hyperinsulinemia, as well as alterations in insulin-like growth factor and adipokine concentrations. Metabolic biomarkers reflecting these processes may not only provide clues for etiological understanding of colorectal carcinogenesis but also might be an alternative way to define an "obesity phenotype" that is relevant for colorectal cancer development

    Multi-spin strings on AdS(5)xT(1,1) and operators of N=1 superconformal theory

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    We study rotating strings with multiple spins in the background of AdS5×T1,1AdS_5\times T^{1,1}, which is dual to a N=1\mathcal{N}=1 superconformal field theory with global symmetry SU(2)×SU(2)×U(1)SU(2)\times SU(2)\times U(1) via the AdS/CFT correspondence. We analyse the limiting behaviour of macroscopic strings and discuss the identification of the dual operators and how their anomalous dimensions should behave as the global charges vary. A class of string solutions we find are dual to operators in SU(2) subsector, and our result implies that the one-loop planar dilatation operator restricted to the SU(2) subsector should be equivalent to the hamiltonian of the integrable Heisenberg spin chain.Comment: 8 pages, revtex4, twocolum

    Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study

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    Background: Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors – healthy weight, physical activity, non-smoking, limited alcohol consumption and a healthy diet, and to explore the association of this index with CRC incidence using data collected within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: In the EPIC cohort, a total of 347,237 men and women, 25- to 70-years old, provided dietary and lifestyle information at study baseline (1992 to 2000). Over a median follow-up time of 12 years, 3,759 incident CRC cases were identified. The association between a HLI and CRC risk was evaluated using Cox proportional hazards regression models and population attributable risks (PARs) have been calculated. Results: After accounting for study centre, age, sex and education, compared with 0 or 1 healthy lifestyle factors, the hazard ratio (HR) for CRC was 0.87 (95% confidence interval (CI): 0.44 to 0.77) for two factors, 0.79 (95% CI: 0.70 to 0.89) for three factors, 0.66 (95% CI: 0.58 to 0.75) for four factors and 0.63 (95% CI: 0.54 to 0.74) for five factors; P-trend <0.0001. The associations were present for both colon and rectal cancers, HRs, 0.61 (95% CI: 0.50 to 0.74; P for trend <0.0001) for colon cancer and 0.68 (95% CI: 0.53 to 0.88; P-trend <0.0001) for rectal cancer, respectively (P-difference by cancer sub-site = 0.10). Overall, 16% of the new CRC cases (22% in men and 11% in women) were attributable to not adhering to a combination of all five healthy lifestyle behaviours included in the index. Conclusions: Combined lifestyle factors are associated with a lower incidence of CRC in European populations characterized by western lifestyles. Prevention strategies considering complex targeting of multiple lifestyle factors may provide practical means for improved CRC prevention. Electronic supplementary material The online version of this article (doi:10.1186/s12916-014-0168-4) contains supplementary material, which is available to authorized users

    Semiclassical Strings, Dipole Deformations of N=1 SYM and Decoupling of KK Modes

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    In this paper we investigate the recently found γ\gamma-deformed Maldacena-Nunez background by studying the behavior of different semiclassical string configurations. This background is conjectured to be dual to dipole deformations of N=1\N=1 SYM. We compare our results to those in the pure Maldacena-Nunez background and show that the energies of our string configurations are higher than in the undeformed background. Thinking in the lines of (hep-th/0505100) we argue that this is an evidence for better decoupling of the Kaluza-Klein modes from the pure SYM theory excitations. Moreover we are able to find a limit of the background in which the string energy is independent of γ\gamma, these strings are interpreted as corresponding to pure gauge theory effects.Comment: 31 pages, references added, new solutions in Section 7 presented, an appendix added, to appear in JHE

    School Rhetoric Techniques in Empress Eudocia’s Poem “Martyrdom of St. Cyprian”

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    Examples of use of school rhetoric techniques (common exercises, figures of thought, figures of speech, tropes) in the poem of Empress Eudocia (V century) “Martyrdom of St. Cyprian” are considered. It is taken into account that the ability to freely use this kind of techniques was the basis of the ancient teaching of rhetoric, which was considered the highest level of education available to a few. It is reported that between school exercises (called progymnasmata) and independent creativity (both in prose and poetry) there was no impenetrable boundary, since the work of late antique and Byzantine authors was born from school. Eudocia’s poem is characterized as a paraphrase (which in itself is a rhetorical exercise) of an already existing life, probably with significant additions and complete replacement of words. It is shown that it is possible to observe the use of ekphrasis in the poem, sermocinatio, antithesis, anaphora, polysyndeton, asyndeton, hyperbola, simple and extended metaphors, etc.). It is proved that in this sense the poem “Martyrdom of St. Cyprian” is a typical example of late antique “scientific” poetry. The author of the article notes that in the case of Eudocia it is unusual only that all the above-mentioned rhetorical techniques are owned by a woman, since only a few women reached this higher level of education, especially in the Christian environment
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