Hypoalbuminemia is a frequent marker of increased mortality in cardiogenic shock

Altres ajuts: VPH was supported by the Aarne Koskelo Foundation (no grant number): http://www. aarnekoskelonsaatio.fi/, and the Finnish Cardiac Foundation (no grant number): https://www. fincardio.fi/. Laboratory kits were provided by Roche Diagnostics. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Introduction The prevalence of hypoalbuminemia, early changes of plasma albumin (P-Alb) levels, and their effects on mortality in cardiogenic shock are unknown. Materials and methods P-Alb was measured from serial blood samples in 178 patients from a prospective multinational study on cardiogenic shock. The association of hypoalbuminemia with clinical characteristics and course of hospital stay including treatment and procedures was assessed. Theprimary outcome was all-cause 90-day mortality. Results Hypoalbuminemia (P-Alb < 34g/L) was very frequent (75%) at baseline in patients with cardiogenic shock. Patients with hypoalbuminemia had higher mortality than patients with normal albumin levels (48% vs. 23%, p = 0.004). Odds ratio for death at 90 days was 2.4 [95% CI 1.5-4.1] per 10 g/L decrease in baseline P-Alb. The association with increased mortality remained independent in regression models adjusted for clinical risk scores developed for cardiogenic shock (CardShock score adjusted odds ratio 2.0 [95% CI 1.1-3.8], IABPSHOCK II score adjusted odds ratio 2.5 [95%CI 1.2-5.0]) and variables associated with hypoalbuminemia at baseline (adjusted odds ratio 2.9 [95%CI 1.2-7.1]). In serial measurements,albumin levels decreased at a similar rate between 0h and 72h in both survivors andnonsurvivors (ΔP-Alb -4.6 g/L vs. 5.4 g/L, p = 0.5). While the decrease was higher for patients with normal P-Alb at baseline (p 0.001 compared to patients with hypoalbuminemia at baseline), the rate of albumin decrease was not associated with outcome. Conclusions Hypoalbuminemia was a frequent finding early in cardiogenic shock, and P-Alb levels decreased during hospital stay. Low P-Alb at baseline was associated with mortality independently of other previously described risk factors. Thus, plasma albumin measurement should be part of the initial evaluation in patients with cardiogenic shock

Vibration parameters selection for a VPJ screen

W referacie opisano sposoby doboru parametrów drgań segmentu przesiewacza VPJ produkowanego przez OFAMA-VIBRA. Wskazano na konsekwencje wykorzystania nieciągłości geometrycznej układu: belka udarowa - pokład sitowy, oraz pokazano konsekwencje rozwiązań uzyskanych w drodze symułacji.The paper describes methods of yibration parameters selection of a VPJ screen section manufactured by the OFAMA-V1BRA. There were indicated consequences of the application of percussive beam — screen tray system geometrica) discontinuity. Consequences of solu- tions obtained in the simulation were shown

Velocity of grain moving upon the surface of WK-type screen

Jednym z najważniejszych parametrów decydujących o pracy przesiewacza jest prędkość ziarn na sicie. Zwiększanie tej prędkości powodować może zwiększenie wydajności kosztem obniżenia skuteczności przesiewania, a obniżanie poprawę skuteczności związaną z wydłużeniem czasu przesiewania. Najbardziej znane wzory na prędkość transportową ziarn na sicie o drganiach kołowych nie dają zadowalających wyników zwłaszcza dla dużych amplitud drgań. Opracowany w latach 90-tych wzór empiryczny nie pozwala jednoznacznie oceniać wpływu poszczególnych parametrów drgań na prędkość ziarn. W pracy zaproponowano prosty wzór empiryczny opracowany na podstawie kilku tysięcy pomiarów pozwalający na dokładniejsze prognozowanie prędkości transportowej.Velocity of grains moving upon the screen surface is one of the major parameters influencing the screening performance. However, increase of the velocity in question may improve the machine efficiency at the cost of sieving effectiveness. Consequently, decrease of the velocity may improve sieving effectiveness, due to the elongation of sieving time. Formulas commonly used to calculate the grains transport velocity on a circular vibration screen are not fully useful, particularly for high amplitudes. Based on the empirical formula proposed in the nineties, unique estimation of the influence of individual vibration parameters upon the grain velocity is hardly possible. A simple empirical formula developed on the basis of thousands of measurements has been proposed in the study. This formula allows more precise prognosis of the grain transport velocity

Characteristics of basic phenotypic traits of the male red deer hunted in Dulowa Forest

The aim of the study was to examine individual quality of red deer males occurring in the Dulowa Forest (S Poland). Carcass weight as well as form and weight of antlers were the main criteria. Analysed deer characterized with good quality of the inter−individual, as shown by the higher (or similar) average carcass and antlers weight compared to the individuals hunted in other regions. In addition high quality of the inter−individual demonstrated by the fact that 17,4% deer had antlers with a medal. The maximum average weight of antlers (7.29 kg) was observed for thirteen−years−old animals, while the culmination of carcass weight (159.8 kg) occurred for twelve−years−old individuals. Weight of the antlers was significantly correlated with age (r=0.88), carcass weight (r=0.84) and form of antlers (r=0.79)

Ocena stanu naprężenia w elementach konstrukcyjnych przesiewacza

This study summarises the results of FEM analysis of the state of stress generated in structural components of a PZ3R screen separator under the typical operating conditions. Simplifications underlying the numerical analysis were verified by measuring the stresses in selected parts of the machine. Resistance test data indicated the directions for further modifications of structural elements of the screen separator, at the same time confirming the adequacy of these tests and emphasising the importance of the sequence of the applied tests.W opracowaniu przedstawiono wyniki analizy numerycznej stanu naprężenia (MES), jaki powstaje w elementach konstrukcyjnych przesiewacza PZ3R w warunkach normalnej eksploatacji. Uproszczenia, jakie wprowadzono na etapie analizy numerycznej, zweryfikowano wykonując pomiar naprężeń w wytypowanych obszarach konstrukcji. Wyniki analiz wytrzymałościowych wskazały kierunki możliwych modyfikacji elementów konstrukcyjnych przesiewacza, a ponadto potwierdziły celowość ich przeprowadzenia, ale przy zachowaniu ściśle określonej kolejności

Strawberry anthocyanin and its association with postprandial inflammation and insulin

The present study investigates the effect of strawberry antioxidants in beverage form on meal-induced postprandial inflammatory and insulin responses in human subjects. Overweight adults (n24) consumed a high-carbohydrate, moderate-fat meal (HCFM) accompanied by either a strawberry or a placebo beverage in a cross-over design. Postprandial changes in plasma anthocyanins, their metabolites, insulin, glucose and inflammatory markers were assessed for 6 h. The postprandial concentrations of pelargonidin sulfate and pelargonidin-3-O-glucoside were significantly increased when the strawberry beverage was consumed concurrently with the HCFM compared with the placebo beverage (P &lt; 0·001). The strawberry beverage significantly attenuated the postprandial inflammatory response as measured by high-sensitivity C-reactive protein and IL-6 (P &lt; 0·05) induced by the HCFM. It was also associated with a reduction in postprandial insulin response (P &lt; 0·05). Collectively, these data provide evidence for favourable effects of strawberry antioxidants on postprandial inflammation and insulin sensitivity.</jats:p

Hypoalbuminemia is a frequent marker of increased mortality in cardiogenic shock

Altres ajuts: VPH was supported by the Aarne Koskelo Foundation (no grant number): http://www. aarnekoskelonsaatio.fi/, and the Finnish Cardiac Foundation (no grant number): https://www. fincardio.fi/. Laboratory kits were provided by Roche Diagnostics. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Introduction The prevalence of hypoalbuminemia, early changes of plasma albumin (P-Alb) levels, and their effects on mortality in cardiogenic shock are unknown. Materials and methods P-Alb was measured from serial blood samples in 178 patients from a prospective multinational study on cardiogenic shock. The association of hypoalbuminemia with clinical characteristics and course of hospital stay including treatment and procedures was assessed. Theprimary outcome was all-cause 90-day mortality. Results Hypoalbuminemia (P-Alb < 34g/L) was very frequent (75%) at baseline in patients with cardiogenic shock. Patients with hypoalbuminemia had higher mortality than patients with normal albumin levels (48% vs. 23%, p = 0.004). Odds ratio for death at 90 days was 2.4 [95% CI 1.5-4.1] per 10 g/L decrease in baseline P-Alb. The association with increased mortality remained independent in regression models adjusted for clinical risk scores developed for cardiogenic shock (CardShock score adjusted odds ratio 2.0 [95% CI 1.1-3.8], IABPSHOCK II score adjusted odds ratio 2.5 [95%CI 1.2-5.0]) and variables associated with hypoalbuminemia at baseline (adjusted odds ratio 2.9 [95%CI 1.2-7.1]). In serial measurements,albumin levels decreased at a similar rate between 0h and 72h in both survivors andnonsurvivors (ΔP-Alb -4.6 g/L vs. 5.4 g/L, p = 0.5). While the decrease was higher for patients with normal P-Alb at baseline (p 0.001 compared to patients with hypoalbuminemia at baseline), the rate of albumin decrease was not associated with outcome. Conclusions Hypoalbuminemia was a frequent finding early in cardiogenic shock, and P-Alb levels decreased during hospital stay. Low P-Alb at baseline was associated with mortality independently of other previously described risk factors. Thus, plasma albumin measurement should be part of the initial evaluation in patients with cardiogenic shock