'You were quiet - I did all the marching': Research processes involved in hearing the voices of South Asian girls

This article is available open access through the publisher’s website at the link below. Copyright @ 2011 A B Academic Publishers.This article provides insights into the outcomes of reflection following two interview approaches used to explore narratives of the lived, individual experiences of South-Asian girls living in West London. In attempting to illuminate and re-present the cultural experiences as told by these girls, the choice of interview approach became critical in allowing the voices to be effectively heard (Rogers, 2005). This article therefore considers how a semi-structured interview approach offered valuable insights into the girls' experiences but became constraining for both researcher and participant in unveiling the complexity and depth of their lives. These constraints emerged through reflection by both participants and researcher. As a result of reflexivity during the research process, the researcher moved towards the use of research conversations during the second phase of the study. Ultimately the study revealed how the girls felt empowered by the opportunity to narrate their individual experiences and tell of their lives. In narrating their reflections on being part of the research, there was a clear recognition that the process facilitated the articulation of new voices and ‘multi-voicedness’ (Moen, 2006

The Influence of Internal Motivation and Work Environment on Employee Productivity

Companies not only expect capable, adequate, and expert employee, but also willing to work hard and have a desire to achieve the optimal results. Their ability, capability, and skills do not mean anything to the companies, if they are not willing to work hard to use their ability, capability, and skill. The motivation to work is needed but the most important is internal motivation to stimulate the employee’s desire to work hard and be enthusiastic to achieve more productivity. An environmental condition is said to be appropriate if a person can carry out their activity optimally, healthily, safely, and comfortably. Incompatible environment emerges in a long term. Furthermore, unfavorable environment conditions requires more energy and time that does not support the efficient framework systems. This purpose of this study is to know the influence of Internal Motivation and Work Environment on Productivity. This study used associative methods of causal correlation. The population in this study is 30 employees of PT. Indosat in Garut Substation. A whole population became sample data in this study, the authors took a sample based on the census methods. The result is productivity able to be influenced by internal motivation because it is highly important for the employee to have internal motivation that is important and influences companies overall. The conclusion is that internal motivation does influence the productivity of the employees.     Keywords: internal motivation, work environment, productivit

3D printing tablets: Predicting printability and drug dissolution from rheological data

Rheology is an indispensable tool for formulation development, which when harnessed, can both predict a material’s performance and provide valuable insight regarding the material’s macrostructure. However, rheological characterizations are under-utilized in 3D printing of drug formulations. In this study, viscosity measurements were used to establish a mathematical model for predicting the printability of fused deposition modelling 3D printed tablets (Printlets). The formulations were composed of polycaprolactone (PCL) with different amounts of ciprofloxacin and polyethylene glycol (PEG), and different molecular weights of PEG. With all printing parameters kept constant, both binary and ternary blends were found to extrude at nozzle temperatures of 130, 150 and 170 °C. In contrast PCL was unextrudable at 130 and 150 °C. Three standard rheological models were applied to the experimental viscosity measurements, which revealed an operating viscosity window of between 100 and 1000 Pa·s at the apparent shear rate of the nozzle. The drug release profiles of the printlets were experimentally measured over seven days. As a proof-of-concept, machine learning models were developed to predict the dissolution behaviour from the viscosity measurements. The machine learning models were discovered to accurately predict the dissolution profile, with the highest f2 similarity score value of 90.9 recorded. Therefore, the study demonstrated that using only the viscosity measurements can be employed for the simultaneous high-throughput screening of formulations that are printable and with the desired release profile

Dysfunctional Audit Behavior in Inspectorate Garut

This study contributes to find the influence of turnover intention and locus of control on dysfunctional audit behavior in Inspektorat Daerah Kabupaten Garut. In this study, the population used as sample was 55 respondents. The methodology of research is quantitative methods and the data were collected through literature review, questionnaires, and interview. Meanwhile the process data were conducted through SPSS Version 20.0 and the analysis method used was Regression Multiplier. The results indicate that turnover intention has no influence on dysfunctional audit behavior, while locus of control is influenced on dysfunctional audit behavior partially. In addition, the turnover intention and locus of control is influenced on dysfunctional audit behaviors simultaneously.     Keywords: turnover intention, locus of control, dysfunctional audit behavio

Pressure-assisted microsyringe 3D printing of oral films based on pullulan and hydroxypropyl methylcellulose

Oral films (OFs) continue to attract attention as drug delivery systems, particularly for pedatric and geriatric needs. However, immiscibility between different polymers limits the full potential of OFs from being explored. One example is pullulan (PUL), a novel biopolymer which often has to be blended with other polymers to reduce cost and alter its mechanical properties. In this study, the state-of-the-art in fabrication techniques, three-dimensional (3D) printing was used to produce hybrid film structures of PUL and hydroxypropyl methylcellulose (HPMC), which were loaded with caffeine as a model drug. 3D printing was used to control the spatial deposition of films. HPMC was found to increase the mean mechanical properties of PUL films, where the tensile strength, elastic modulus and elongation break increased from 8.9 to 14.5 MPa, 1.17 to 1.56 GPa and from 1.48% to 1.77%, respectively. In addition, the spatial orientation of the hybrid films was also explored to determine which orientation could maximize the mechanical properties of the hybrid films. The results revealed that 3D printing could modify the mechanical properties of PUL whilst circumventing the issues associated with immiscibility

Fixed points of Suzuki type generalized multivalued mappings in fuzzy metric spaces with applications

The aim of this paper is to introduce a class of multivalued mappings satisfying a Suzuki type generalized contractive condition in the framework of fuzzy metric spaces and to present fixed point results for such mappings. Some examples are presented to support the results proved herein. As an application, a common fixed point result for a hybrid pair of single and multivalued mappings is obtained. We show the existence and uniqueness of a common bounded solution of functional equations arising in dynamic programming. Our results generalize and extend various results in the existing literature.http://link.springer.com/journal/11784hb201

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ‘accidental cell death’ (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. ‘Regulated cell death’ (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry

Agronomic performance of five rice varieties and nutritive value of the straw from these varieties

Two separate experiments were conducted to assess the grain and straw yield (Exp. 1), chemical composition and in vitro gas production (Exp. 2) of five varieties of rice; Hybrid, Exbaika, Jasmine 85, IR841 and Long grain ordinary 2. Experiment 1 was conducted in a randomized complete block design with four replicates per variety. After harvesting, the rice straw from each variety was combined with Kapok leaf meal (KLM) at three inclusion levels (0, 25, 50%) to formulate a diet. The sole rice straw and formulated diets were analyzed for crude protein (CP), neutral detergent fiber (NDF), acid detergent fiber (ADF) and Ash. Approximately 0.2 g of each diet (sole and formulated) was incubated in a McDougall’s buffered rumen fluid under anaerobic condition for the in vitro gas production. The varieties differed (P < 0.05) in relation to plant height, maturity days, percentage emergence, tiller number, straw yield and harvest index but did not differ in grain yield. The percentage emergence was in the range of 72.5 and 85.0%. with the highest (P = 0.003) recorded in the Hybrid variety. Plant height ranged from 90.5 to 110.8 cm with the highest (P = 0.046) reported in variety Long grain ordinary 2. Variety Long grain ordinary 2 had the longest (P<0.001) mean maturity days with the least recorded in the Hybrid variety. The highest (P < 0.05) straw yield was reported in variety Exbaika whilst Jasmine 85 had the least straw yield and harvest index. The CP concentration of the rice straw varieties increased numerically with an increase in the level of KLM. The NDF ranged from 622 g/kg DM to 913 g/kg DM for IR842 variety with 0% KLM and Long grain ordinary 2 variety with 25% KLM respectively. The ADF was in the range of 299.7 g/kg DM to 483.6 g/kg DM with the lowest reported in IR842 variety with 50% KLM. Mean asymptote gas production (b), fractional rate of gas production (c), in vitro gas production (IVGP) and in vitro organic matter digestibility (IVOMD) were not affected (P <0.05) by the variety x KLM inclusion level interaction. However, IVGP at 24 h and IVOMD both differed (P < 0.05) by variety. Varieties Jasmine 85, IR842 and Long grain ordinary 2 had higher IVGP and IVOMD as compared to the other two varieties. It was observed from the study that varieties IR841 and Long grain ordinary 2 provided higher grain and fodder production. The use of KLM as a replacement enhanced the nutrient composition, fermentation characteristics and digestibility

Evaluation of Road Safety Hazardous Conditions in a Road Network

The paper presents a methodology to evaluate safety hazardous condition in a road network. Poor and delayed maintenance of roads leads to road accidents. Several maintenance components like poor surface condition (pothole, rutting, shoulder drop-off), improper traffic signs, road marking, poor lighting etc. affects road safety. Road maintenance is generally limited to improving carriageway surface condition like filling pothole etc. without replacing missing traffic signs, road marking and other safety features essential for a safe road network. Maintaining the roads in safe condition require huge resources in form of man machine and materials. Thus, Identification and evaluation of maintenance components effects on road safety is very important task for assessing the maintenance needs for improving road safety. Limited studies are available on identification of effects of maintenance components on road safety. A methodology is developed based on the identification of effect of poor maintenance on road safety and by considering inter-relationship between various maintenance components. Also a methodology is developed to evaluate the effects of these components on road safety. It is expected that this study will be useful in assessing the maintenance needs and effectiveness of various maintenance components in improving road safety. Keywords: Road Maintenance, Road Safety, Maintenance Components, Safety Hazardous Conditions