A compendium of genetic regulatory effects across pig tissues

The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biological discovery and exploitation in animal breeding and human biomedicine. Here we show results from the pilot phase of PigGTEx by processing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples passing quality control from pigs. We build a pig genotype imputation panel and associate millions of genetic variants with five types of transcriptomic phenotypes in 34 tissues. We evaluate tissue specificity of regulatory effects and elucidate molecular mechanisms of their action using multi-omics data. Leveraging this resource, we decipher regulatory mechanisms underlying 207 pig complex phenotypes and demonstrate the similarity of pigs to humans in gene expression and the genetic regulation behind complex phenotypes, supporting the importance of pigs as a human biomedical model.</p

A New Look at the Scalar Meson f0(500)f_0(500) via D+→π+π−ℓ+νℓD^+\to \pi^+\pi^-\ell^+\nu_\ell Decays

Using $2.93~\mathrm{fb}^{-1}$ of $e^+e^-$ collision data collected with the BESIII detector at the center-of-mass energy of 3.773 GeV, we investigate the semileptonic decays $D^+\to \pi^+\pi^- \ell^+\nu_\ell$ ($\ell=e$ and $\mu$). The $D^+\to f_0(500)\mu^+\nu_\mu$ decay is observed for the first time. By analyzing simultaneously the differential decay rates of $D^+\to f_0(500) \mu^+\nu_\mu$ and $D^+\to f_0(500) e^+\nu_e$ in different $\ell^+\nu_\ell$ four-momentum transfer intervals, the product of the relevant hadronic form factor $f^{f_0}_{+}(0)$ and the magnitude of the $c\to d$ Cabibbo-Kobayashi-Maskawa matrix element $|V_{cd}|$ is determined to be $f_{+}^{f_0} (0)|V_{cd}|=0.0787\pm0.0060_{\rm stat}\pm0.0033_{\rm syst}$ for the first time. With the input of $|V_{cd}|$ from the global fit in the standard model, we determine $f_{+}^{f_0} (0)=0.350\pm0.027_{\rm stat}\pm0.015_{\rm syst}$. The absolute branching fractions of $D^+\to f_0(500)_{(\pi^+\pi^-)}\mu^+\nu_\mu$ and $D^+\to \rho^0_{(\pi^+\pi^-)} \mu^+\nu_\mu$ are determined as $(0.72\pm0.13_{\rm stat}\pm0.10_{\rm syst})\times10^{-3}$ and $(1.64\pm0.13_{\rm stat}\pm0.11_{\rm syst})\times 10^{-3}$. Combining these results with those of previous BESIII measurements on their semielectronic counterparts from the same data sample, we test lepton flavor universality by measuring the branching fraction ratios ${\mathcal B}_{D^+\to \rho^0 \mu^+\nu_\mu}/{\mathcal B}_{D^+\to \rho^0 e^+\nu_e}=0.88\pm0.10$ and ${\mathcal B}_{D^+\to f_0(500) \mu^+\nu_\mu}/{\mathcal B}_{D^+\to f_0(500) e^+\nu_e}=1.14\pm0.28$, which are compatible with the standard model expectation.Comment: Supplemental Materials added in this versio

Study of the decays χcJ→ΛΛˉω\chi_{cJ}\to\Lambda\bar{\Lambda}\omega

Using $(27.12\pm 0.14)\times10^{8}$ $\psi(3686)$ events collected with the BESIII detector, we present the first observation of the decays $\chi_{cJ}\to\Lambda\bar{\Lambda}\omega$, where $J=0, 1, 2$, with statistical significances of $11.7 \sigma, 11.2 \sigma$, and $11.8 \sigma$. The branching fractions of these decays are determined to be $\mathcal{B}(\chi_{c0}\to\Lambda\bar{\Lambda}\omega)=({2.37 \pm 0.22 \pm 0.23}) \times 10^{-4}$, $\mathcal{B}(\chi_{c1}\to\Lambda\bar{\Lambda}\omega)=({1.01 \pm 0.10 \pm 0.11}) \times 10^{-4}$, and $\mathcal{B}(\chi_{c2}\to\Lambda\bar{\Lambda}\omega)=({1.40 \pm 0.13 \pm 0.17}) \times 10^{-4}$, where the first uncertainties are statistical and the second are systematic. We observe no clear intermediate structures.Comment: 11 pages, 10 figure

Measurements of the branching fractions of semileptonic Ds+D^{+}_s decays via e+e−→Ds∗+Ds∗−e^+e^-\to D_s^{*+}D_s^{*-}

We measure the absolute branching fractions of semileptonic $D^+_s$ decays via the $e^+e^-\to D_s^{*+}D_s^{*-}$ process using $e^+e^-$ collision data corresponding to an integrated luminosity of $10.64~\mathrm{fb}^{-1}$ collected by the BESIII detector at center-of-mass energies between 4.237 and 4.699 GeV. The branching fractions are ${\mathcal B}(D_s^+\to \eta e^+\nu_e)=(2.35\pm0.11_{\rm stat}\pm 0.10_{\rm syst})\%,$ ${\mathcal B}(D_s^+\to \eta^\prime e^+\nu_e)=(0.82\pm0.09_{\rm stat}\pm 0.04_{\rm syst})\%,$ ${\mathcal B}(D_s^+\to \phi e^+\nu_e)=(2.21\pm0.16_{\rm stat}\pm 0.11_{\rm syst})\%,$ ${\mathcal B}(D_s^+\to f_0(980) e^+\nu_e,f_0(980)\to\pi^+\pi^-)=(0.15\pm0.02_{\rm stat}\pm 0.01_{\rm syst})\%,$ ${\mathcal B}(D_s^+\to K^0 e^+\nu_e)=(0.24\pm0.04_{\rm stat}\pm 0.01_{\rm syst})\%,$ and ${\mathcal B}(D_s^+\to K^{*0} e^+\nu_e)=(0.19\pm0.03_{\rm stat}\pm 0.01_{\rm syst})\%.$ These results are consistent with those measured via the $e^+e^-\to D_s^{*\pm}D_s^{\mp}$ process by BESIII and CLEO. The hadronic transition form factors $D^+_s\to \eta e^+\nu_e$, $D^+_s\to \eta^\prime e^+\nu_e$, and $D^+_s\to K^0 e^+\nu_e$ at four-momentum transfer squared $q^2$ = 0 are determined to be $f^{\eta}_+(0) = 0.482 \pm 0.011_{\rm stat} \pm 0.009_{\rm syst}\pm0.004_{\rm input},$ $f^{\eta^{\prime}}_+(0) = 0.562 \pm 0.031_{\rm stat} \pm 0.014_{\rm syst}\pm0.003_{\rm input},$ and $f^{K^0}_+(0) = 0.624 \pm 0.052_{\rm stat} \pm 0.013_{\rm syst}\pm0.002_{\rm input}.$Comment: 14 pages, 3 figure

Amplitude Analysis of the Decays D0→π+π−π+π−D^0\to\pi^+\pi^-\pi^+\pi^- and π+π−π0π0\pi^+\pi^-\pi^0\pi^0

Using $e^+e^-$ annihilation data corresponding to an integrated luminosity of 2.93 $\rm fb^{-1}$ taken at the center-of-mass energy $\sqrt{s}=3.773$~GeV with the BESIII detector, a joint amplitude analysis is performed on the decays $D^0\to\pi^+\pi^-\pi^+\pi^-$ and $D^0\to\pi^+\pi^-\pi^0\pi^0$(non-$\eta$). The fit fractions of individual components are obtained, and large interferences among the dominant components of $D^{0}\to a_{1}(1260)\pi$, $D^{0}\to\pi(1300)\pi$, $D^{0}\to\rho(770)\rho(770)$ and $D^{0}\to2(\pi\pi)_{S}$ are found in both channels. With the obtained amplitude model, the $CP$-even fractions of $D^0\to \pi^+\pi^-\pi^+\pi^-$ and $D^0\to\pi^+\pi^-\pi^0\pi^0$(non-$\eta$) are determined to be $(75.2\pm1.1_{\rm stat.}\pm1.5_{\rm syst.})\%$ and $(68.9\pm1.5_{\rm stat.}\pm 2.4_{\rm syst.})\%$, respectively. The branching fractions of $D^0\to \pi^+\pi^-\pi^+\pi^-$ and $D^0\to\pi^+\pi^-\pi^0\pi^0$(non-$\eta$) are measured to be $(0.688\pm0.010_{\rm stat.}\pm 0.010_{\rm syst.})\%$ and $(0.951\pm0.025_{\rm stat.}\pm 0.021_{\rm syst.})\%$, respectively. The amplitude analysis provides an important model for binning strategy in the measurements of the strong phase parameters of $D^0 \to 4\pi$ when used to determine the CKM angle $\gamma (\phi_{3})$ via the $B^{-}\to D K^{-}$ decay

Measurement of the Electromagnetic Transition Form-factors in the decays η′→π+π−l+l−\eta'\rightarrow\pi^+\pi^-l^+l^-

With a sample of $(10087\pm44)\times10^{6}$ $J/\psi$ events accumulated with the BESIII detector, we analyze the decays $\eta'\rightarrow\pi^+\pi^-l^+l^-(l=e,$ $\mu)$ via the process $J/\psi\rightarrow\gamma\eta'$. The branching fractions are measured to be $\mathcal{B}(\eta'\rightarrow\pi^+\pi^-e^+e^-)=(2.45\pm0.02(\rm{stat.})\pm0.08(\rm{syst.})) \times10^{-3}$ and $\mathcal{B}(\eta'\rightarrow\pi^+\pi^-\mu^+\mu^-)=(2.16\pm0.12(\rm{stat.})\pm0.06(\rm{syst.}))\times10^{-5}$, and the ratio is $\frac{\mathcal{B}(\eta'\rightarrow\pi^{+}\pi^{-}e^{+}e^{-})}{\mathcal{B}(\eta'\rightarrow\pi^{+}\pi^{-}\mu^{+}\mu^{-})} = 113.4\pm0.9(\rm{stat.})\pm3.7(\rm{syst.})$. In addition, by combining the $\eta'\rightarrow\pi^+\pi^-e^+e^-$ and $\eta'\rightarrow\pi^+\pi^-\mu^+\mu^-$ decays, the slope parameter of the electromagnetic transition form factor is measured to be $b_{\eta'}=1.30\pm0.19\ (\mathrm{GeV}/c^{2})^{-2}$, which is consistent with previous measurements from BESIII and theoretical predictions from the VMD model. The asymmetry in the angle between the $\pi^+\pi^-$ and $l^+l^-$ decay planes, which has the potential to reveal the $CP$-violation originating from an unconventional electric dipole transition, is also investigated. The asymmetry parameters are determined to be $\mathcal{A}_{CP}(\eta'\rightarrow\pi^+\pi^-e^+e^-)=(-0.21\pm0.73(\rm{stat.})\pm0.01(\rm{syst.}))\%$ and $\mathcal{A}_{CP}(\eta'\rightarrow\pi^+\pi^-\mu^+\mu^-)=(0.62\pm4.71(\rm{stat.})\pm0.08(\rm{syst.}))\%$, implying that no evidence of $CP$-violation is observed at the present statistics. Finally, an axion-like particle is searched for via the decay $\eta'\rightarrow\pi^+\pi^-a, a\rightarrow e^+e^-$, and upper limits of the branching fractions are presented for the mass assumptions of the axion-like particle in the range of $0-500\ \mathrm{MeV}/c^{2}$

Search for X(1870)X(1870) via the decay J/ψ→ωK+K−ηJ/\psi\to \omega K^+ K^-\eta

Using a sample of $(10087\pm 44)\times10^{6}$ $J/\psi$ events collected by the BESIII detector at the BEPCII collider, we search for the decay $X(1870)\to K^+ K^-\eta$ via the $J/\psi\to \omega K^+ K^- \eta$ process for the first time. No significant $X(1870)$ signal is observed. The upper limit on the branching fraction of the decay $J/\psi\to \omega X(1870) \to\omega K^+ K^- \eta$ is determined to be $9.55\times 10^{-7}$ at the $90\%$ confidence level. In addition, the branching faction $B(J/\psi\to\omega K^+ K^- \eta)$ is measured to be $(3.33\pm0.02(\rm{stat.})\pm 0.12(\rm{syst.}))\times 10^{-4}$

Measurement of the absolute branching fraction of the three-body decay Λc+→Ξ0K+π0\Lambda_{c}^+ \to \Xi^{0}K^{+}\pi^{0} and search for Λc+→nK+π0\Lambda_{c}^+ \to nK^+\pi^0, Σ0K+π0\Sigma^{0}K^{+}\pi^{0} and ΛK+π0\Lambda K^{+}\pi^{0}

The Cabbibo-favored decay $\Lambda_{c}^+ \to \Xi^{0}K^{+}\pi^{0}$ is studied for the first time using 6.1 fb$^{-1}$ of $e^+e^-$ collision data at center-of-mass energies between 4.600 and 4.840 GeV, collected with the BESIII detector at the BEPCII collider. With a double-tag method, the branching fraction of the three-body decay $\Lambda_{c}^+ \to \Xi^{0}K^{+}\pi^{0}$ is measured to be $(7.79 \pm 1.46 _{\rm} \pm0.71 _{\rm}) \times 10^{ - 3}$, where the first and second uncertainties are statistical and systematic, respectively. The branching fraction of the two-body decay $\Lambda_{c}^+ \to \Xi(1530)^{0}K^+$ is $(5.99\pm1.04\pm0.29)\times10^{-3}$, which is consistent with the previous result of $(5.02\pm0.99\pm0.31)\times 10^{-3}$. In addition, the upper limit on the branching fraction of the doubly Cabbibo-suppressed decay $\Lambda_{c}^+ \to nK^+\pi^0$ is $7.1 \times 10^{-4}$ at the 90$\%$ confidence level. The upper limits on the branching fractions of $\Lambda_{c}^+ \to \Sigma^{0}K^{+}\pi^{0}$ and $\Lambda K^{+}\pi^{0}$ are also determined to be $1.8\times 10^{-3}$ and $2.0 \times 10^{-3}$, respectively.Comment: 15 pages, 20 figure

First Measurement of the Decay Asymmetry in the pure W-boson-exchange Decay Λc+→Ξ0K+\Lambda_{c}^{+}\to\Xi^{0}K^{+}

Based on $4.4~\text{fb}^{-1}$ of $e^{+}e^{-}$ annihilation data collected at the center-of-mass energies between $4.60$ and $4.70~\text{GeV}$ with the BESIII detector at the BEPCII collider, the pure \textit{W}-boson-exchange decay $\Lambda_{c}^{+}\to\Xi^{0}K^{+}$ is studied with a full angular analysis. The corresponding decay asymmetry is measured for the first time to be $\alpha_{\Xi^{0}K^{+}}=0.01\pm0.16({\rm stat.})\pm0.03({\rm syst.})$. This result reflects the non-interference effect between the $S$- and $P$-wave amplitudes. The phase shift between $S$- and $P$-wave amplitudes has two solutions, which are $\delta_{p}-\delta_{s}=-1.55\pm0.25({\rm stat.})\pm0.05({\rm syst.})~\text{rad}$ or $1.59\pm0.25({\rm stat.})\pm0.05({\rm syst.})~\text{rad}$