Current and noise correlations in a double dot Cooper pair beam splitter

We consider a double quantum dot coupled to two normal leads and one superconducting lead, modeling the Cooper pair beam splitter studied in two recent experiments. Starting from a microscopic Hamiltonian we derive a general expression for the branching current and the noise crossed correlations in terms of single and two-particle Green's function of the dot electrons. We then study numerically how these quantities depend on the energy configuration of the dots and the presence of direct tunneling between them, isolating the various processes which come into play. In absence of direct tunneling, the antisymmetric case (the two levels have opposite energies with respect to the superconducting chemical potential) optimizes the Crossed Andreev Reflection (CAR) process while the symmetric case (the two levels have the same energies) favors the Elastic Cotunneling (EC) process. Switching on the direct tunneling tends to suppress the CAR process, leading to negative noise crossed correlations over the whole voltage range for large enough direct tunneling

Current correlations in the interacting Cooper-pair beam-splitter

We propose an approach allowing the computation of currents and their correlations in interacting multiterminal mesoscopic systems involving quantum dots coupled to normal and/or superconducting leads. The formalism relies on the expression of branching currents and noise crossed correlations in terms of one- and two-particle Green's functions for the dots electrons, which are then evaluated self-consistently within a conserving approximation. We then apply this to the Cooper-pair beam-splitter setup recently proposed [L. Hofstetter et al. Nature (London) 461 960 (2009); Phys. Rev. Lett. 107 136801 (2011); L. G. Herrmann et al. Phys. Rev. Lett. 104 026801 (2010)], which we model as a double quantum dot with weak interactions, connected to a superconducting lead and two normal ones. Our method not only enables us to take into account a local repulsive interaction on the dots, but also to study its competition with the direct tunneling between dots. Our results suggest that even a weak Coulomb repulsion tends to favor positive current cross correlations in the antisymmetric regime (where the dots have opposite energies with respect to the superconducting chemical potential)

Gamma-ray burst contributions to constraining the evolution of dark energy

We explore the gamma-ray bursts' (GRBs') contributions in constraining the dark energy equation of state (EOS) at high ($1.8 < z < 7$) and at middle redshifts ($0.5 < z < 1.8$) and estimate how many GRBs are needed to get substantial constraints at high redshifts. We estimate the constraints with mock GRBs and mock type Ia supernovae (SNe Ia) for comparisons. When constraining the dark energy EOS in a certain redshift range, we allow the dark energy EOS parameter to vary only in that redshift bin and fix EOS parameters elsewhere to -1. We find that it is difficult to constrain the dark energy EOS beyond the redshifts of SNe Ia with GRBs unless some new luminosity relations for GRBs with smaller scatters are discovered. However, at middle redshifts, GRBs have comparable contributions with SNe Ia in constraining the dark energy EOS.Comment: 3 pages, 5 figures. Published in Astronomy and Astrophysics. Corrected referenc

Growth and optical properties of GaN/AlN quantum wells

We demonstrate the growth of GaN/AlN quantum well structures by plasma-assisted molecular-beam epitaxy by taking advantage of the surfactant effect of Ga. The GaN/AlN quantum wells show photoluminescence emission with photon energies in the range between 4.2 and 2.3 eV for well widths between 0.7 and 2.6 nm, respectively. An internal electric field strength of $9.2\pm 1.0$ MV/cm is deduced from the dependence of the emission energy on the well width.Comment: Submitted to AP

Off-diagonal long-range order, cycle probabilities, and condensate fraction in the ideal Bose gas

We discuss the relationship between the cycle probabilities in the path-integral representation of the ideal Bose gas, off-diagonal long-range order, and Bose--Einstein condensation. Starting from the Landsberg recursion relation for the canonic partition function, we use elementary considerations to show that in a box of size L^3 the sum of the cycle probabilities of length k >> L^2 equals the off-diagonal long-range order parameter in the thermodynamic limit. For arbitrary systems of ideal bosons, the integer derivative of the cycle probabilities is related to the probability of condensing k bosons. We use this relation to derive the precise form of the \pi_k in the thermodynamic limit. We also determine the function \pi_k for arbitrary systems. Furthermore we use the cycle probabilities to compute the probability distribution of the maximum-length cycles both at T=0, where the ideal Bose gas reduces to the study of random permutations, and at finite temperature. We close with comments on the cycle probabilities in interacting Bose gases.Comment: 6 pages, extensive rewriting, new section on maximum-length cycle

Identification of systemic immune response markers through metabolomic profiling of plasma from calves given an intra-nasally delivered respiratory vaccine

International audienceVaccination procedures within the cattle industry are important disease control tools to minimize economic and welfare burdens associated with respiratory pathogens. However, new vaccine, antigen and carrier technologies are required to combat emerging viral strains and enhance the efficacy of respiratory vaccines, particularly at the point of pathogen entry. New technologies, specifically metabolomic profiling, could be applied to identify metabolite immune-correlates representative of immune protection following vaccination aiding in the design and screening of vaccine candidates. This study for the first time demonstrates the ability of untargeted UPLC-MS metabolomic profiling to identify metabolite immune correlates characteristic of immune responses following mucosal vaccination in calves. Male Holstein Friesian calves were vaccinated with Pfizer Rispoval® PI3 + RSV intranasal vaccine and metabolomic profiling of post-vaccination plasma revealed 12 metabolites whose peak intensities differed significantly from controls. Plasma levels of glycocholic acid, N-[(3α,5β,12α)-3,12-Dihydroxy-7,24-dioxocholan-24-yl]glycine, uric acid and biliverdin were found to be significantly elevated in vaccinated animals following secondary vaccine administration, whereas hippuric acid significantly decreased. In contrast, significant upregulation of taurodeoxycholic acid and propionylcarnitine levels were confined to primary vaccine administration. Assessment of such metabolite markers may provide greater information on the immune pathways stimulated from vaccine formulations and benchmarking early metabolomic responses to highly immunogenic vaccine formulations could provide a means for rapidly assessing new vaccine formulations. Furthermore, the identification of metabolic systemic immune response markers which relate to specific cell signaling pathways of the immune system could allow for targeted vaccine design to stimulate key pathways which can be assessed at the metabolic level

Outcomes of haploidentical stem cell transplantation for chronic lymphocytic leukemia: a retrospective study on behalf of the chronic malignancies working party of the EBMT

Allogeneic hematopoietic stem cell transplantation (HCT) may result in long-term disease control in high-risk chronic lymphocytic leukemia (CLL). Recently, haploidentical HCT is gaining interest because of better outcomes with post-transplantation cyclophosphamide (PTCY). We analyzed patients with CLL who received an allogeneic HCT with a haploidentical donor and whose data were available in the EBMT registry. In total 117 patients (74% males) were included; 38% received PTCY as GVHD prophylaxis. For the whole study cohort OS at 2 and 5 yrs was 48 and 38%, respectively. PFS at 2 and 5 yrs was 38 and 31%, respectively. Cumulative incidence (CI) of NRM in the whole group at 2 and 5 years were 40 and 44%, respectively. CI of relapse at 2 and 5 yrs were 22 and 26%, respectively. All outcomes were not statistically different in patients who received PTCY compared to other types of GVHD prophylaxis. In conclusion, results of haploidentical HCT in CLL seem almost identical to those with HLA-matched donors. Thereby, haploidentical HCT is an appropriate alternative in high risk CLL patients with a transplant indication but no available HLA-matched donor. Despite the use of PTCY, the CI of relapse seems not higher than observed after HLA-matched HCT

Design of a Polarised Positron Source Based on Laser Compton Scattering

We describe a scheme for producing polarised positrons at the ILC from polarised X-rays created by Compton scattering of a few-GeV electron beam off a CO2 or YAG laser. This scheme is very energy effective using high finesse laser cavities in conjunction with an electron storage ring.Comment: Proposal submitted to the ILC workshop, Snowmass 2005. v2: note number adde

On the growth of perturbations in interacting dark energy and dark matter fluids

The covariant generalizations of the background dark sector coupling suggested in G. Mangano, G. Miele and V. Pettorino, Mod. Phys. Lett. A 18, 831 (2003) are considered. The evolution of perturbations is studied with detailed attention to interaction rate that is proportional to the product of dark matter and dark energy densities. It is shown that some classes of models with coupling of this type do not suffer from early time instabilities in strong coupling regime.Comment: 11 pages, 2 figures. v3: minor changes, typos fixe

Carbon storage and DNA absorption in allophanic soils and paleosols

Andisols and andic paleosols dominated by the nanocrystalline mineral allophane sequester large amounts of carbon (C), attributable mainly to its chemical bonding with charged hydroxyl groups on the surface of allophane together with its physical protection in nanopores within and between allophane nanoaggregates. C near-edge X-ray absorption fine structure (NEXAFS) spectra for a New Zealand Andisol (Tirau series) showed that the organic matter (OM) mainly comprises quinonic, aromatic, aliphatic, and carboxylic C. In different buried horizons from several other Andisols, C contents varied but the C species were similar, attributable to pedogenic processes operating during developmental upbuilding, downward leaching, or both. The presence of OM in natural allophanic soils weakened the adsorption of DNA on clay; an adsorption isotherm experiment involving humic acid (HA) showed that HA-free synthetic allophane adsorbed seven times more DNA than HA-rich synthetic allophane. Phosphorus X-ray absorption near-edge structure (XANES) spectra for salmonsperm DNA and DNA-clay complexes indicated that DNA was bound to the allophane clay through the phosphate group, but it is not clear if DNA was chemically bound to the surface of the allophane or to OM, or both. We plan more experiments to investigate interactions among DNA, allophane (natural and synthetic), and OM. Because DNA shows a high affinity to allophane, we are studying the potential to reconstruct late Quaternary palaeoenvironments by attempting to extract and characterise ancient DNA from allophanic paleosol