Off-Mass-Shell π\piN Scattering and pp→ppπ0pp \to pp \pi^0

We adapt the off-shell $\pi$N amplitude of the Tucson-Melbourne three-body force to the half-off-shell amplitude of the pion rescattering contribution to $pp \to pp \pi^0$ near threshold. This {\em pion} rescattering contribution, together with the impulse term, provides a good description of the data when the half-off-shell amplitude is linked to the phenomenological invariant amplitudes obtained from meson factory $\pi$N scattering data.Comment: 3 pages, contributed to STORRI99, Bloomington, Indiana, September 199

Momentum and Coordinate Space Three-nucleon Potentials

In this paper we give explicit formulae in momentum and coordinate space for the three-nucleon potentials due to $\rho$ and $\pi$ meson exchange, derived from off-mass-shell meson-nucleon scattering amplitudes which are constrained by the symmetries of QCD and by the experimental data. Those potentials have already been applied to nuclear matter calculations. Here we display additional terms which appear to be the most important for nuclear structure. The potentials are decomposed in a way that separates the contributions of different physical mechanisms involved in the meson-nucleon amplitudes. The same type of decomposition is presented for the $\pi - \pi$ TM force: the $\Delta$, the chiral symmetry breaking and the nucleon pair terms are isolated.Comment: LATEX, 33 pages, 3 figures (available as postscript files upon request

Triton calculations with π\pi and ρ\rho exchange three-nucleon forces

The Faddeev equations are solved in momentum space for the trinucleon bound state with the new Tucson-Melbourne $\pi$ and $\rho$ exchange three-nucleon potentials. The three-nucleon potentials are combined with a variety of realistic two-nucleon potentials. The dependence of the triton binding energy on the $\pi NN$ cut-off parameter in the three-nucleon potentials is studied and found to be reduced compared to the case with pure $\pi$ exchange. The $\rho$ exchange parts of the three-nucleon potential yield an overall repulsive effect. When the recommended parameters are employed, the calculated triton binding energy turns out to be very close to its experimental value. Expectation values of various components of the three-nucleon potential are given to illustrate their significance for binding.Comment: 17 pages Revtex 3.0, 4 figures. Accepted for publication in Phys. Rev.

Phenomenological Aspects of Isospin Violation in the Nuclear Force

Phenomenological Lagrangians and dimensional power counting are used to assess isospin violation in the nucleon-nucleon force. The $\pi NN$ coupling constants (including the Goldberger-Treiman discrepancy), charge-symmetry breaking, and meson-mixing models are examined. A one-loop analysis of the isospin-violating $\pi NN$ coupling constants is performed using chiral perturbation theory. Meson-mixing models and the $^3$He - $^3$H mass difference are also discussed in the context of naturalness.Comment: 10 pages, latex, 1 figure -- To appear in Physics Letters B -- epsfig.sty require

ρ\rho-ω\omega mixing and spin dependent CSV potential

We construct the charge symmetry violating (CSV) nucleon-nucleon potential induced by the $\rho^0$-\o mixing due to the neutron-proton mass difference driven by the $NN$ loop. Analytical expression for for the two-body CSV potential is presented containing both the central and non- central $NN$ interaction. We show that the $\rho$$NN$ tensor interaction can significantly enhance the charge symmetry violating $NN$ interaction even if momentum dependent off-shell $\rho^0$-$\omega$ mixing amplitude is considered. It is also shown that the inclusion of form factors removes the divergence arising out of the contact interaction. Consequently, we see that the precise size of the computed scattering length difference depends on how the short range aspects of the CSV potential are treated.Comment: Accepted for publication in Phys. Rev.

Off-shell Behavior of the π ⁣− ⁣η\pi\!-\!\eta Mixing Amplitude

We extend a recent calculation of the momentum dependence of the $\rho-\omega$ mixing amplitude to the pseudoscalar sector. The $\pi\!-\!\eta$ mixing amplitude is calculated in a hadronic model where the mixing is driven by the neutron-proton mass difference. Closed-form analytic expressions are presented in terms of a few nucleon-meson parameters. The observed momentum dependence of the mixing amplitude is strong enough as to question earlier calculations of charge-symmetry-breaking observables based on the on-shell assumption. The momentum dependence of the $\pi\!-\!\eta$ amplitude is, however, practically identical to the one recently predicted for $\rho-\omega$ mixing. Hence, in this model, the ratio of pseudoscalar to vector mixing amplitudes is, to a good approximation, a constant solely determined from nucleon-meson coupling constants. Furthermore, by selecting these parameters in accordance with charge-symmetry-conserving data and SU(3)-flavor symmetry, we reproduce the momentum dependence of the $\pi\!-\!\eta$ mixing amplitude predicted from chiral perturbation theory. Alternatively, one can use chiral-perturbation-theory results to set stringent limits on the value of the $NN\eta$ coupling constant.Comment: 13 pages, Latex with Revtex, 3 postscript figures (not included) available on request, SCRI-03089

Charge-Asymmetry of the Nucleon-Nucleon Interaction

Based upon the Bonn meson-exchange model for the nucleon-nucleon ($NN$) interaction, we study systematically the charge-symmetry-breaking (CSB) of the $NN$ interaction due to nucleon mass splitting. Particular attention is payed to CSB generated by the $2\pi$-exchange contribution to the $NN$ interaction, $\pi\rho$ diagrams, and other multi-meson-exchanges. We calculate the CSB differences in the $^1S_0$ effective range parameters as well as phase shift differences in $S$, $P$ and higher partial waves up to 300 MeV lab. energy. We find a total CSB difference in the singlet scattering length of 1.6 fm which explains the empirical value accurately. The corresponding CSB phase-shift differences are appreciable at low energy in the $^1S_0$ state. In the other partial waves, the CSB splitting of the phase shifts is small and increases with energy, with typical values in the order of 0.1 deg at 300 MeV in $P$ and $D$ waves.Comment: 11 pages, RevTex, 14 figure

Novel PDE4 inhibitors derived from Chinese medicine Forsythia

Cyclic adenosine monophosphate (cAMP) is a crucial intracellular second messenger molecule that converts extracellular molecules to intracellular signal transduction pathways generating cell- and stimulus-specific effects. Importantly, specific phosphodiesterase (PDE) subtypes control the amplitude and duration of cAMP-induced physiological processes and are therefore a prominent pharmacological target currently used in a variety of fields. Here we tested the extracts from traditional Chinese medicine, Forsythia suspense seeds, which have been used for more than 2000 years to relieve respiratory symptoms. Using structural-functional analysis we found its major lignin, Forsynthin, acted as an immunosuppressant by inhibiting PDE4 in inflammatory and immune cell. Moreover, several novel, selective small molecule derivatives of Forsythin were tested in vitro and in murine models of viral and bacterial pneumonia, sepsis and cytokine-driven systemic inflammation. Thus, pharmacological targeting of PDE4 may be a promising strategy for immune-related disorders characterized by amplified host inflammatory response