The noise properties of 42 millisecond pulsars from the European Pulsar Timing Array and their impact on gravitational wave searches

The sensitivity of Pulsar Timing Arrays to gravitational waves depends on the noise present in the individual pulsar timing data. Noise may be either intrinsic or extrinsic to the pulsar. Intrinsic sources of noise will include rotational instabilities, for example. Extrinsic sources of noise include contributions from physical processes which are not sufficiently well modelled, for example, dispersion and scattering effects, analysis errors and instrumental instabilities. We present the results from a noise analysis for 42 millisecond pulsars (MSPs) observed with the European Pulsar Timing Array. For characterising the low-frequency, stochastic and achromatic noise component, or "timing noise", we employ two methods, based on Bayesian and frequentist statistics. For 25 MSPs, we achieve statistically significant measurements of their timing noise parameters and find that the two methods give consistent results. For the remaining 17 MSPs, we place upper limits on the timing noise amplitude at the 95% confidence level. We additionally place an upper limit on the contribution to the pulsar noise budget from errors in the reference terrestrial time standards (below 1%), and we find evidence for a noise component which is present only in the data of one of the four used telescopes. Finally, we estimate that the timing noise of individual pulsars reduces the sensitivity of this data set to an isotropic, stochastic GW background by a factor of >9.1 and by a factor of >2.3 for continuous GWs from resolvable, inspiralling supermassive black-hole binaries with circular orbits.Comment: Accepted for publication by the Monthly Notices of the Royal Astronomical Societ

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response

We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by which B cells regulate the host neutrophilic response upon exposure to mycobacteria and how neutrophilia may influence vaccine efficacy. To address these questions, a murine aerosol infection tuberculosis (TB) model and an intradermal (ID) ear BCG immunization mouse model, involving both the μMT strain and B cell-depleted C57BL/6 mice, were used. IL (interleukin)-17 neutralization and neutrophil depletion experiments using these systems provide evidence that B cells can regulate neutrophilia by modulating the IL-17 response during M. tuberculosis infection and BCG immunization. Exuberant neutrophilia at the site of immunization in B cell-deficient mice adversely affects dendritic cell (DC) migration to the draining lymph nodes and attenuates the development of the vaccine-induced Th1 response. The results suggest that B cells are required for the development of optimal protective anti-TB immunity upon BCG vaccination by regulating the IL-17/neutrophilic response. Administration of sera derived from M. tuberculosis-infected C57BL/6 wild-type mice reverses the lung neutrophilia phenotype in tuberculous μMT mice. Together, these observations provide insight into the mechanisms by which B cells and humoral immunity modulate vaccine-induced Th1 response and regulate neutrophila during M. tuberculosis infection and BCG immunization. © 2013 Kozakiewicz et al

Tuberculosis immunopathology: the neglected role of extracellular matrix destruction

The extracellular matrix in the lung must be destroyed for Mycobacterium tuberculosis—the agent that causes tuberculosis (TB)—to spread. The current paradigm proposes that this destruction occurs as a result of the action of proinflammatory cytokines, chemokines, immune cells, and lipids that mediate TB-associated necrosis in the lung. However, this view neglects the fact that lung matrix can only be degraded by proteases. We propose an original conceptual framework of TB immunopathology that may lead directly to treatments that involve inhibition of matrix metalloproteinase activity to hinder matrix destruction and reduce the morbidity and mortality associated with T

Discovery of Pulsed γ\gamma-rays from PSR J0034-0534 with the Fermi LAT: A Case for Co-located Radio and γ\gamma-ray Emission Regions

Millisecond pulsars (MSPs) have been firmly established as a class of gamma-ray emitters via the detection of pulsations above 0.1 GeV from eight MSPs by the Fermi Large Area Telescope (LAT). Using thirteen months of LAT data significant gamma-ray pulsations at the radio period have been detected from the MSP PSR J0034-0534, making it the ninth clear MSP detection by the LAT. The gamma-ray light curve shows two peaks separated by 0.274$\pm$0.015 in phase which are very nearly aligned with the radio peaks, a phenomenon seen only in the Crab pulsar until now. The $\geq$0.1 GeV spectrum of this pulsar is well fit by an exponentially cutoff power law with a cutoff energy of 1.8$\pm 0.6\pm$0.1 GeV and a photon index of 1.5$\pm 0.2\pm$0.1, first errors are statistical and second are systematic. The near-alignment of the radio and gamma-ray peaks strongly suggests that the radio and gamma-ray emission regions are co-located and both are the result of caustic formation.Comment: 20 pages, 3 figures, 2 tables. Accepted for publication in Ap

Detection of Bursts from FRB 121102 with the Effelsberg 100-m Radio Telescope at 5 GHz and the Role of Scintillation

FRB 121102, the only repeating fast radio burst (FRB) known to date, was discovered at 1.4 GHz and shortly after the discovery of its repeating nature, detected up to 2.4 GHz. Here we present three bursts detected with the 100-m Effelsberg radio telescope at 4.85 GHz. All three bursts exhibited frequency structure on broad and narrow frequency scales. Using an autocorrelation function analysis, we measured a characteristic bandwidth of the small-scale structure of 6.4$\pm$1.6 MHz, which is consistent with the diffractive scintillation bandwidth for this line of sight through the Galactic interstellar medium (ISM) predicted by the NE2001 model. These were the only detections in a campaign totaling 22 hours in 10 observing epochs spanning five months. The observed burst detection rate within this observation was inconsistent with a Poisson process with a constant average occurrence rate; three bursts arrived in the final 0.3 hr of a 2 hr observation on 2016 August 20. We therefore observed a change in the rate of detectable bursts during this observation, and we argue that boosting by diffractive interstellar scintillations may have played a role in the detectability. Understanding whether changes in the detection rate of bursts from FRB 121102 observed at other radio frequencies and epochs are also a product of propagation effects, such as scintillation boosting by the Galactic ISM or plasma lensing in the host galaxy, or an intrinsic property of the burst emission will require further observations.Comment: Accepted to ApJ. Minor typos correcte

Orbital effects of a monochromatic plane gravitational wave with ultra-low frequency incident on a gravitationally bound two-body system

We analytically compute the long-term orbital variations of a test particle orbiting a central body acted upon by an incident monochromatic plane gravitational wave. We assume that the characteristic size of the perturbed two-body system is much smaller than the wavelength of the wave. Moreover, we also suppose that the wave's frequency is much smaller than the particle's orbital one. We make neither a priori assumptions about the direction of the wavevector nor on the orbital geometry of the planet. We find that, while the semi-major axis is left unaffected, the eccentricity, the inclination, the longitude of the ascending node, the longitude of pericenter and the mean anomaly undergo non-vanishing long-term changes. They are not secular trends because of the slow modulation introduced by the tidal matrix coefficients and by the orbital elements themselves. They could be useful to indepenedently constrain the ultra-low frequency waves which may have been indirectly detected in the BICEP2 experiment. Our calculation holds, in general, for any gravitationally bound two-body system whose characteristic frequency is much larger than the frequency of the external wave. It is also valid for a generic perturbation of tidal type with constant coefficients over timescales of the order of the orbital period of the perturbed particle.Comment: LaTex2e, 24 pages, no figures, no tables. Changes suggested by the referees include

The PALFA Survey: Going to great depths to find radio pulsars

The on-going PALFA survey is searching the Galactic plane (|b| < 5 deg., 32 < l < 77 deg. and 168 < l < 214 deg.) for radio pulsars at 1.4 GHz using ALFA, the 7-beam receiver installed at the Arecibo Observatory. By the end of August 2012, the PALFA survey has discovered 100 pulsars, including 17 millisecond pulsars (P < 30 ms). Many of these discoveries are among the pulsars with the largest DM/P ratios, proving that the PALFA survey is capable of probing the Galactic plane for millisecond pulsars to a much greater depth than any previous survey. This is due to the survey's high sensitivity, relatively high observing frequency, and its high time and frequency resolution. Recently the rate of discoveries has increased, due to a new more sensitive spectrometer, two updated complementary search pipelines, the development of online collaborative tools, and access to new computing resources. Looking forward, focus has shifted to the application of artificial intelligence systems to identify pulsar-like candidates, and the development of an improved full-resolution pipeline incorporating more sophisticated radio interference rejection. The new pipeline will be used in a complete second analysis of data already taken, and will be applied to future survey observations. An overview of recent developments, and highlights of exciting discoveries will be presented.Comment: Proceedings of IAUS 291 "Neutron Stars and Pulsars: Challenges and Opportunities after 80 years", J. van Leeuwen (ed.); 6 pages, 4 figure

Pulsar Timing and its Application for Navigation and Gravitational Wave Detection

Pulsars are natural cosmic clocks. On long timescales they rival the precision of terrestrial atomic clocks. Using a technique called pulsar timing, the exact measurement of pulse arrival times allows a number of applications, ranging from testing theories of gravity to detecting gravitational waves. Also an external reference system suitable for autonomous space navigation can be defined by pulsars, using them as natural navigation beacons, not unlike the use of GPS satellites for navigation on Earth. By comparing pulse arrival times measured on-board a spacecraft with predicted pulse arrivals at a reference location (e.g. the solar system barycenter), the spacecraft position can be determined autonomously and with high accuracy everywhere in the solar system and beyond. We describe the unique properties of pulsars that suggest that such a navigation system will certainly have its application in future astronautics. We also describe the on-going experiments to use the clock-like nature of pulsars to "construct" a galactic-sized gravitational wave detector for low-frequency (f_GW ~1E-9 - 1E-7 Hz) gravitational waves. We present the current status and provide an outlook for the future.Comment: 30 pages, 9 figures. To appear in Vol 63: High Performance Clocks, Springer Space Science Review

A millisecond pulsar in an extremely wide binary system

International audienceWe report on 22 yrs of radio timing observations of the millisecond pulsar J1024−0719 by the telescopes participating in the European Pulsar Timing Array (EPTA). These observations reveal a significant second derivative of the pulsar spin frequency and confirm the discrepancy between the parallax and Shklovskii distances that has been reported earlier. We also present optical astrometry, photometry and spectroscopy of 2MASS J10243869−0719190. We find that it is a low-metallicity main-sequence star (K7V spectral type, [M/H] = −1.0, T eff = 4050 ± 50 K) and that its position, proper motion and distance are consistent with those of PSR J1024−0719. We conclude that PSR J1024−0719 and 2MASS J10243869−0719190 form a common proper motion pair and are gravitationally bound. The gravitational interaction between the main-sequence star and the pulsar accounts for the spin frequency derivatives , which in turn resolves the distance discrepancy. Our observations suggest that the pulsar and main-sequence star are in an extremely wide (P b > 200 yr) orbit. Combining the radial velocity of the companion and proper motion of the pulsar, we find that the binary system has a high spatial velocity of 384 ± 45 km s −1 with respect to the local standard of rest and has a Galactic orbit consistent with halo objects. Since the observed main-sequence companion star cannot have recycled the pulsar to millisecond spin periods, an exotic formation scenario is required. We demonstrate that this extremely wide-orbit binary could have evolved from a triple system that underwent an asymmetric supernova explosion, though find that significant fine-tuning during the explosion is required. Finally, we discuss the implications of the long period orbit on the timing stability of PSR J1024−0719 in light of its inclusion in pulsar timing arrays

From spin noise to systematics:stochastic processes in the first International Pulsar Timing Array data release

We analyse the stochastic properties of the 49 pulsars that comprise the first International Pulsar Timing Array (IPTA) data release. We use Bayesian methodology, performing model selection to determine the optimal description of the stochastic signals present in each pulsar. In addition to spin-noise and dispersion-measure (DM) variations, these models can include timing noise unique to a single observing system, or frequency band. We show the improved radio-frequency coverage and presence of overlapping data from different observing systems in the IPTA data set enables us to separate both system and band-dependent effects with much greater efficacy than in the individual pulsar timing array (PTA) data sets. For example, we show that PSR J1643-1224 has, in addition to DM variations, significant band-dependent noise that is coherent between PTAs which we interpret as coming from time-variable scattering or refraction in the ionized interstellar medium. Failing to model these different contributions appropriately can dramatically alter the astrophysical interpretation of the stochastic signals observed in the residuals. In some cases, the spectral exponent of the spin-noise signal can vary from 1.6 to 4 depending upon the model, which has direct implications for the long-term sensitivity of the pulsar to a stochastic gravitational-wave (GW) background. By using a more appropriate model, however, we can greatly improve a pulsar's sensitivity to GWs. For example, including system and band-dependent signals in the PSR J0437-4715 data set improves the upper limit on a fiducial GW background by similar to 60 per cent compared to a model that includes DM variations and spin-noise only