The views of older women towards mammographic screening: a qualitative and quantitative study

Purpose: Mammographic screening has improved breast cancer survival in the screened age group. This improved survival has not been seen in older women (>70 years) where screening uptake is low. This study explores the views, knowledge and attitudes of older women towards screening. Methods: Women (>70) were interviewed about breast screening. Interview findings informed the development of a questionnaire which was sent to 1000 women (>70) to quantify their views regarding screening. Results: Twenty-six women were interviewed and a questionnaire designed. The questionnaire response rate was 48.3% (479/992). Over half (52.9%, 241/456) of respondents were unaware they could request mammography by voluntary self-referral and were unaware of how to arrange this. Most (81.5% 383/470) had not attended breast screening since turning 70. Most (75.6%, 343/454) felt screening was beneficial and would attend if invited. Most, (90.1%, 412/457) felt screening should be offered to all women regardless of age or health. Conclusions: There is a lack of knowledge about screening in older women. The majority felt that invitation to screening should be extended to the older age group regardless of age or health. The current under-utilised system of voluntary self referral is not supported by older women

Use of sonic tomography to detect and quantify wood decay in living trees.

Premise of the studyField methodology and image analysis protocols using acoustic tomography were developed and evaluated as a tool to estimate the amount of internal decay and damage of living trees, with special attention to tropical rainforest trees with irregular trunk shapes.Methods and resultsLiving trunks of a diversity of tree species in tropical rainforests in the Republic of Panama were scanned using an Argus Electronic PiCUS 3 Sonic Tomograph and evaluated for the amount and patterns of internal decay. A protocol using ImageJ analysis software was used to quantify the proportions of intact and compromised wood. The protocols provide replicable estimates of internal decay and cavities for trees of varying shapes, wood density, and bark thickness.ConclusionsSonic tomography, coupled with image analysis, provides an efficient, noninvasive approach to evaluate decay patterns and structural integrity of even irregularly shaped living trees

Strong 3D correlations in vortex system of Bi2212:Pb

The experimental study of magnetic flux penetration under crossed magnetic fields in Bi2212:Pb single crystal performed by magnetooptic technique (MO) reveals remarkable field penetration pattern alteration (flux configuration change) and superconducting current anisotropy enhancement by the in-plane field. The anisotropy increases with the temperature rise up to $T_m = 54 \pm 2 K$. At $T = T_m$ an abrupt change in the flux behavior is found; the correlation between the in-plane magnetic field and the out-of-plane magnetic flux penetration disappears. No correlation is observed for $T > T_m$. The transition temperature $T_m$ does not depend on the magnetic field strength. The observed flux penetration anisotropy is considered as an evidence of a strong 3D - correlation between pancake vortices in different CuO planes at $T < T_m$. This enables understanding of a remarkable pinning observed in Bi2212:Pb at low temperatures.Comment: 8 pages, 9 figure

Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group.

Cancer immunotherapy has transformed the treatment of cancer. However, increasing use of immune-based therapies, including the widely used class of agents known as immune checkpoint inhibitors, has exposed a discrete group of immune-related adverse events (irAEs). Many of these are driven by the same immunologic mechanisms responsible for the drugs\u27 therapeutic effects, namely blockade of inhibitory mechanisms that suppress the immune system and protect body tissues from an unconstrained acute or chronic immune response. Skin, gut, endocrine, lung and musculoskeletal irAEs are relatively common, whereas cardiovascular, hematologic, renal, neurologic and ophthalmologic irAEs occur much less frequently. The majority of irAEs are mild to moderate in severity; however, serious and occasionally life-threatening irAEs are reported in the literature, and treatment-related deaths occur in up to 2% of patients, varying by ICI. Immunotherapy-related irAEs typically have a delayed onset and prolonged duration compared to adverse events from chemotherapy, and effective management depends on early recognition and prompt intervention with immune suppression and/or immunomodulatory strategies. There is an urgent need for multidisciplinary guidance reflecting broad-based perspectives on how to recognize, report and manage organ-specific toxicities until evidence-based data are available to inform clinical decision-making. The Society for Immunotherapy of Cancer (SITC) established a multidisciplinary Toxicity Management Working Group, which met for a full-day workshop to develop recommendations to standardize management of irAEs. Here we present their consensus recommendations on managing toxicities associated with immune checkpoint inhibitor therapy

Unsupervised Induction of Modern Standard Arabic Verb Classes

We exploit the resources in the Arabic Treebank (ATB) for the novel task of automatically creating lexical semantic verb classes for Modern Standard Arabic (MSA). Verbs are clustered into groups that share semantic elements of meaning as they exhibit similar syntactic behavior. The results of the clustering experiments are compared with a gold standard set of classes, which is approximated by using the noisy English translations provided in the ATB to create Levin-like classes for MSA. The quality of the clusters is found to be sensitive to the inclusion of information about lexical heads of the constituents in the syntactic frames, as well as parameters of the clustering algorithm. The best set of parameters yields an Fβ=1 score of 0.501, compared to a random baseline with an Fβ=1 score of 0.37