Botulinum Toxin A for the Treatment of Keloids

Introduction: Keloids are the result of excessive scar tissue formation. Besides their poor aesthetic appearance, keloids can be associated with severe clinical symptoms such as pain, itching, and rigidity. Unfortunately, most therapeutic approaches remain clinically unsatisfactory. Recently, injections with botulinum toxin A (BTA) were proposed for the treatment of established keloids in a clinical trial. In this study, we aimed to verify the effects of intralesional BTA for the treatment of therapy-resistant keloids using objective measurements. In addition, the underlying molecular mechanisms were investigated using cultured keloid-derived fibroblasts. Materials and Methods: Four patients received BTA (doses varying from 70 to 140 Speywood units per session) injected directly into their keloids every 2 months for up to 6 months. Differences in height and volume were evaluated clinically and measured with a 3-D optical profiling system. Keloid-derived fibroblasts were treated with different concentrations of BTA, and expression of collagen (COL)1A1, COL1A2, COL3A1, TGF-beta 1, TGF-beta 2, TGF-beta 3, fibronectin-1, laminin-beta 2, and alpha-SMA was determined by real-time quantitative PCR. MTT and BrdU assays were used to analyze the effects of BTA on fibroblast proliferation and metabolism. Results: Intralesional administration of BTA did not result in regression of keloid tissue. No differences in expression of ECM markers, collagen synthesis, or TGF-beta could be observed after BTA treatment of keloid fibroblasts. In addition, cell proliferation and metabolism of keloid fibroblasts was not affected by BTA treatment. Conclusion: The suggested clinical efficiency of intralesional BTA for the therapy of existent keloids could not be confirmed in this study. Based on our data, the potential mechanisms of action of BTA on keloid-derived fibroblasts remain unclear. Copyright (C) 2012 S. Karger AG, Base

GSFC short pulse radar, JONSWAP-75

In September 1975, the Goddard Space Flight Center operated a short pulse radar during ocean wave measuring experiments off the coast of West Germany in the North Sea. The experiment was part of JONSWAP-75. The radar system and operations during the experiment are described along with examples of data

Resonance f0(1500)f_0(1500): Is it a scalar glueball ?

The ratios of partial widths for the decay of a glueball into two pseudoscalar mesons are calculated under the assumption that the production of light quark pairs ($u\bar u,d\bar d,s\bar s$) in soft gluon-\-induced reactions goes on within universal symmetry breaking. Parameter of the violation of flavour symmetry is fixed by the central hadron production data in high energy hadron collisions and/or by the ratios of radiative decay amplitudes $J/\Psi \to \gamma\eta/\gamma\eta'$ and $J/\Psi \to \gamma \phi \phi/\gamma \omega \omega$. The ratios of coupling constants $glueball\to\pi\pi,K\bar K, \eta\eta,\eta\eta'$ which are calculated with this parameter coincide reasonably with those of $f_0(1500)$, supporting an idea about glueball nature of $f_0(1500)$.Comment: LaTex, 8 pages, 2 .eps figures in one uuencoded file, uses epsfi

Near-Threshold eta Meson Production in Proton-Proton Collisions

The production of eta mesons has been measured in the proton-proton interaction close to the reaction threshold using the COSY-11 internal facility at the cooler synchrotron COSY. Total cross sections were determined for eight different excess energies in the range from 0.5 MeV to 5.4 MeV. The energy dependence of the total cross section is well described by the available phase-space volume weighted by FSI factors for the proton-proton and proton-eta pairs.Comment: 9 pages, 1 table, 5 figure

Instanton Effects in the Decay of Scalar Mesons

We show that instanton effects may play a crucial role in the decay of scalar mesons into two pseudoscalars. Particularly the branching ratios of two meson decays of the $f_0(1500)$, which is considered as a glue-ball candidate, are then compatible with an ordinary $q \bar{q}$-structure of this resonance and a small positive SU(3) mixing angle, close to a result recently calculated with the same instanton-induced force.Comment: 9 pages, uuencoded latex including two figure

New results on the pd --> 3He eta production near threshold

Measurements on the eta meson production in proton-deuteron collisions have been performed using the COSY-11 facility at COSY Juelich. Here we present preliminary results on total and differential cross sections for the pd --> 3He eta reaction at five excess energies between Q = 5.1 and Q = 40.6 MeV. The obtained angular distributions for the emitted eta mesons in the center of mass system expose a transition from an almost isotropic emission to a highly anisotropic distribution. The extracted total cross sections support a strong eta-3He final state interaction and will be compared with model predictions.Comment: Presented at MESON 2004: 8th International Workshop on Meson Production, Properties and Interactions, Cracow, Poland, 4-8 Jun 2004, 3 pages, Submitted to Int. J. Mod. Phys.

The harmonic oscillator on Riemannian and Lorentzian configuration spaces of constant curvature

The harmonic oscillator as a distinguished dynamical system can be defined not only on the Euclidean plane but also on the sphere and on the hyperbolic plane, and more generally on any configuration space with constant curvature and with a metric of any signature, either Riemannian (definite positive) or Lorentzian (indefinite). In this paper we study the main properties of these `curved' harmonic oscillators simultaneously on any such configuration space, using a Cayley-Klein (CK) type approach, with two free parameters \ki, \kii which altogether correspond to the possible values for curvature and signature type: the generic Riemannian and Lorentzian spaces of constant curvature (sphere ${\bf S}^2$, hyperbolic plane ${\bf H}^2$, AntiDeSitter sphere {\bf AdS}^{\unomasuno} and DeSitter sphere {\bf dS}^{\unomasuno}) appear in this family, with the Euclidean and Minkowski spaces as flat limits. We solve the equations of motion for the `curved' harmonic oscillator and obtain explicit expressions for the orbits by using three different methods: first by direct integration, second by obtaining the general CK version of the Binet's equation and third, as a consequence of its superintegrable character. The orbits are conics with centre at the potential origin in any CK space, thereby extending this well known Euclidean property to any constant curvature configuration space. The final part of the article, that has a more geometric character, presents those results of the theory of conics on spaces of constant curvature which are pertinent.Comment: 29 pages, 6 figure

The long-time dynamics of two hydrodynamically-coupled swimming cells

Swimming micro-organisms such as bacteria or spermatozoa are typically found in dense suspensions, and exhibit collective modes of locomotion qualitatively different from that displayed by isolated cells. In the dilute limit where fluid-mediated interactions can be treated rigorously, the long-time hydrodynamics of a collection of cells result from interactions with many other cells, and as such typically eludes an analytical approach. Here we consider the only case where such problem can be treated rigorously analytically, namely when the cells have spatially confined trajectories, such as the spermatozoa of some marine invertebrates. We consider two spherical cells swimming, when isolated, with arbitrary circular trajectories, and derive the long-time kinematics of their relative locomotion. We show that in the dilute limit where the cells are much further away than their size, and the size of their circular motion, a separation of time scale occurs between a fast (intrinsic) swimming time, and a slow time where hydrodynamic interactions lead to change in the relative position and orientation of the swimmers. We perform a multiple-scale analysis and derive the effective dynamical system - of dimension two - describing the long-time behavior of the pair of cells. We show that the system displays one type of equilibrium, and two types of rotational equilibrium, all of which are found to be unstable. A detailed mathematical analysis of the dynamical systems further allows us to show that only two cell-cell behaviors are possible in the limit of $t\to\infty$, either the cells are attracted to each other (possibly monotonically), or they are repelled (possibly monotonically as well), which we confirm with numerical computations

Drift chamber with a c-shaped frame

We present the construction of a planar drift chamber with wires stretched between two arms of a c-shaped aluminium frame. The special shape of the frame allows to extendthe momentum acceptance of the COSY-11 detection system towards lower momenta without suppressing the high momentum particles. The proposed design allows for construction of tracking detectors covering small angles with respect to the beam, which can be installed and removed without dismounting the beam-pipe. For a three-dimensional track reconstruction a computer code was developed using a simple algorithm of hit preselection.Comment: submitted to Nucl. Instr. & Meth

Schottky-based band lineups for refractory semiconductors

An overview is presented of band alignments for small-lattice parameter, refractory semiconductors. The band alignments are estimated empirically through the use of available Schottky barrier height data, and are compared to theoretically predicted values. Results for tetrahedrally bonded semiconductors with lattice constant values in the range from C through ZnSe are presented. Based on the estimated band alignments and the recently demonstrated p-type dopability of GaN, we propose three novel heterojunction schemes which seek to address inherent difficulties in doping or electrical contact to wide-gap semiconductors such as ZnO, ZnSe, and ZnS