Interactive graphical computer-aided design system

System is used for design, layout, and modification of large-scale-integrated (LSI) metal-oxide semiconductor (MOS) arrays. System is structured around small computer which provides real-time support for graphics storage display unit with keyboard, slave display unit, hard copy unit, and graphics tablet for designer/computer interface

Flight elements: Fault detection and fault management

Fault management for an intelligent computational system must be developed using a top down integrated engineering approach. An approach proposed includes integrating the overall environment involving sensors and their associated data; design knowledge capture; operations; fault detection, identification, and reconfiguration; testability; causal models including digraph matrix analysis; and overall performance impacts on the hardware and software architecture. Implementation of the concept to achieve a real time intelligent fault detection and management system will be accomplished via the implementation of several objectives, which are: Development of fault tolerant/FDIR requirement and specification from a systems level which will carry through from conceptual design through implementation and mission operations; Implementation of monitoring, diagnosis, and reconfiguration at all system levels providing fault isolation and system integration; Optimize system operations to manage degraded system performance through system integration; and Lower development and operations costs through the implementation of an intelligent real time fault detection and fault management system and an information management system

AX J0049.4-7323 - a close look at a neutron star interacting with a circumstellar disk

Detailed evidence on the system AX J0049.4-7323 is presented here to show how the passage of the neutron star in the binary system disrupts the circumstellar disk of the mass donor Be star. A similar effect is noted in three other Be/X-ray binary systems. Together the observational data should provide valuable tools for modelling these complex interactions.Comment: 4 pages, accepted for publication in MNRA

Discovery of the Central Excess Brightness in Hard X-rays in the Cluster of Galaxies Abell 1795

Using the X-ray data from \ASCA, spectral and spatial properties of the intra-cluster medium (ICM) of the cD cluster Abell 1795 are studied, up to a radial distance of $\sim 12'$ ($\sim 1.3$ $h_{50}^{-1}$ kpc). The ICM temperature and abundance are spatially rather constant, although the cool emission component is reconfirmed in the central region. The azimuthally- averaged radial X-ray surface brightness profiles are very similar between soft (0.7--3 keV) and hard (3--10 keV) energy bands, and neither can be fitted with a single-$\beta$ model due to a strong data excess within $\sim5'$ of the cluster center. In contrast, double-$\beta$ models can successfully reproduce the overall brightness profiles both in the soft and hard energy bands, as well as that derived with the \ROSAT PSPC. Properties of the central excess brightness are very similar over the 0.2--10 keV energy range spanned by \ROSAT and \ASCA. Thus, the excess X-ray emission from the core region of this cluster is confirmed for the first time in hard X-rays above 3 keV. This indicates that the shape of the gravitational potential becomes deeper than the King-type one towards the cluster center. Radial profiles of the total gravitating matter, calculated using the double-$\beta$ model, reveal an excess mass of $\sim 3 \times 10^{13}~ M_{\odot}$ within $\sim 150 h^{-1}_{50}$ kpc of the cluster center. This suggests a hierarchy in the gravitational potential corresponding to the cD galaxy and the entire cluster.Comment: 27 pages, 8 figures; to appear ApJ 500 (June 20, 1998

Normalizing the Temperature Function of Clusters of Galaxies

We re-examine the constraints which can be robustly obtained from the observed temperature function of X-ray cluster of galaxies. The cluster mass function has been thoroughly studied in simulations and analytically, but a direct simulation of the temperature function is presented here for the first time. Adaptive hydrodynamic simulations using the cosmological Moving Mesh Hydro code of Pen (1997a) are used to calibrate the temperature function for different popular cosmologies. Applying the new normalizations to the present-day cluster abundances, we find $\sigma_8=0.53\pm 0.05 \Omega_0^{-0.45}$ for a hyperbolic universe, and $\sigma_8=0.53\pm 0.05 \Omega_0^{-0.53}$ for a spatially flat universe with a cosmological constant. The simulations followed the gravitational shock heating of the gas and dark matter, and used a crude model for potential energy injection by supernova heating. The error bars are dominated by uncertainties in the heating/cooling models. We present fitting formulae for the mass-temperature conversions and cluster abundances based on these simulations.Comment: 20 pages incl 5 figures, final version for ApJ, corrected open universe \gamma relation, results unchange

Metabolism of low-density lipoproteins by cultured hepatocytes from normal and homozygous familial hypercholesterolemic subjects

The profoundly elevated concentrations of low-density lipoproteins (LDL) present in homozygous familial hypercholesterolemia lead to symptomatic cardiovascular disease and death by early adulthood. Studies conducted in nonhepatic tissues demonstrated defective cellular recognition and metabolism of LDL in these patients. Since mammalian liver removes at least half of the LDL in the circulation, the metabolism of LDL by cultured hepatocytes isolated from familial hypercholesterolemic homozygotes was compared to hepatcytes from normal individuals. Fibroblast studies demonstrated that the familial hypercholesterolemic subjects studied were LDL receptor-negative (less than 1% normal receptor activity) and LDL receptor-de fective (18% normal receptor activity). Cholesterol-depleted hepatocytes from normal subjects bound and internalized 125I-labeled LDL (Bmax = 2.2 μg LDL/mg cell protein). Preincubation of normal hepatocytes with 200 μg/ml LDL reduced binding and internalization by approx. 40%. In contrast, 125I-labeled LDL binding and internalization by receptor-negative familial hypercholesterolemic hepatocytes was unaffected by cholesterol loading and considerably lower than normal. This residual LDL uptake could not be ascribed to fluid phase endocytosis as determined by [14C]sucrose uptake. The residual LDL binding by familial hypercholesterolemia hepatocytes led to a small increase in hepatocyte cholesterol content which was relatively ineffective in reducing hepatocyte 3-hydroxy-3-methylglutaryl-CoA reductase activity. Receptordefective familial hypercholesterolemia hepatocytes retained some degree of regulatable 125I-labeled LDL uptake, but LDL uptake did not lead to normal hepatocyte cholesterol content or 3-hydroxy-3-methylglutaryl-CoA reductase activity. These combined results indicate that the LDL receptor abnormality present in familial hypercholesterolemia fibroblasts reflects deranged hepatocyte LDL recognition and metabolism. In addition, a low-affinity, nonsaturable uptake process for LDL is present in human liver which does not efficiently modulate hepatocyte cholesterol content or synthesis. © 1986

A Very Hot, High Redshift Cluster of Galaxies: More Trouble for Omega_0 = 1

We have observed the most distant (z=0.829) cluster of galaxies in the Einstein Extended Medium Sensitivity Survey, with the ASCA and ROSAT satellites. We find an X-ray temperature of 12.3 +3.1/-2.2 keV for this cluster, and the ROSAT map reveals significant substructure. The high temperature of MS1054-0321 is consistent with both its approximate velocity dispersion, based on the redshifts of 12 cluster members we have obtained at the Keck and the Canada-France-Hawaii telescopes, and with its weak lensing signature. The X-ray temperature of this cluster implies a virial mass ~ 7.4 x 10^14 h^-1 solar masses, if the mean matter density in the universe equals the critical value, or larger if Omega_0 < 1. Finding such a hot, massive cluster in the EMSS is extremely improbable if clusters grew from Gaussian perturbations in an Omega_0 = 1 universe. Combining the assumptions that Omega_0 = 1 and that the intial perturbations were Gaussian with the observed X-ray temperature function at low redshift, we show that the probability of this cluster occurring in the volume sampled by the EMSS is less than a few times 10^{-5}. Nor is MS1054-0321 the only hot cluster at high redshift; the only two other $z > 0.5$ EMSS clusters already observed with ASCA also have temperatures exceeding 8 keV. Assuming again that the initial perturbations were Gaussian and Omega_0 = 1, we find that each one is improbable at the < 10^{-2} level. These observations, along with the fact that these luminosities and temperatures of the high-$z$ clusters all agree with the low-z L_X-T_X relation, argue strongly that Omega_0 < 1. Otherwise, the initial perturbations must be non-Gaussian, if these clusters' temperatures do indeed reflect their gravitational potentials.Comment: 20 pages, 4 figures, To appear in 1 Aug 1998 ApJ (heavily revised version of original preprint

Quasi-hydrostatic intracluster gas under radiative cooling

Quasi-hydrostatic cooling of the intracluster gas is studied. In the quasi-hydrostatic model, work done by gravity on the inflow gas with dP \neq 0, where P is the gas pressure, is taken into account in the thermal balance. The gas flows in from the outer part so as to compensate the pressure loss of the gas undergoing radiative cooling, but the mass flow is so moderate and smooth that the gas is considered to be quasi-hydrostatic. The temperature of the cooling gas decreases toward the cluster center, but, unlike cooling flows with dP = 0, approaches a constant temperature of \sim 1/3 the temperature of the non-cooling ambient gas. This does not mean that gravitational work cancels out radiative cooling, but means that the temperature of the cooling gas appears to approach a constant value toward the cluster center if the gas maintains the quasi-hydrostatic balance. We discuss the mass flow in quasi-hydrostatic cooling, and compare it with the standard isobaric cooling flow model. We also discuss the implication of \dot{M} for the standard cooling flow model.Comment: 5 pages, 1 figure, accepted for publication in A&

The binary period and outburst behaviour of the SMC X-ray binary pulsar system SXP504

A probable binary period has been detected in the optical counterpart to the X-ray source CXOU J005455.6-724510 = RX J0054.9-7245 = AXJ0054.8-7244 = SXP504 in the Small Magellanic Cloud. This source was detected by Chandra on 04 Jul 2002 and subsequently observed by XMM-Newton on 18 Dec 2003. The source is coincident with an Optical Gravitational Lensing (OGLE) object in the lightcurves of which several optical outburst peaks are visible at ~ 268 day intervals. Timing analysis shows a period of 268.6 +/- 0.1 days at > 99% significance. Archival Rossi X-ray Timing Explorer (RXTE) data for the 504s pulse-period has revealed detections which correspond closely with predicted or actual peaks in the optical data. The relationship between this orbital period and the pulse period of 504s is within the normal variance found in the Corbet diagram.Comment: Accepted by MNRAS. 1 LATEX page. 4 figure