Electroconvulsive therapy mediates neuroplasticity of white matter microstructure in major depression.

Whether plasticity of white matter (WM) microstructure relates to therapeutic response in major depressive disorder (MDD) remains uncertain. We examined diffusion tensor imaging (DTI) correlates of WM structural connectivity in patients receiving electroconvulsive therapy (ECT), a rapidly acting treatment for severe MDD. Tract-Based Spatial Statistics (TBSS) applied to DTI data (61 directions, 2.5 mm(3) voxel size) targeted voxel-level changes in fractional anisotropy (FA), and radial (RD), axial (AD) and mean diffusivity (MD) in major WM pathways in MDD patients (n=20, mean age: 41.15 years, 10.32 s.d.) scanned before ECT, after their second ECT and at transition to maintenance therapy. Comparisons made at baseline with demographically similar controls (n=28, mean age: 39.42 years, 12.20 s.d.) established effects of diagnosis. Controls were imaged twice to estimate scanning-related variance. Patients showed significant increases of FA in dorsal fronto-limbic circuits encompassing the anterior cingulum, forceps minor and left superior longitudinal fasciculus between baseline and transition to maintenance therapy (P<0.05, corrected). Decreases in RD and MD were observed in overlapping regions and the anterior thalamic radiation (P<0.05, corrected). Changes in DTI metrics associated with therapeutic response in tracts showing significant ECT effects differed between patients and controls. All measures remained stable across time in controls. Altered WM microstructure in pathways connecting frontal and limbic areas occur in MDD, are modulated by ECT and relate to therapeutic response. Increased FA together with decreased MD and RD, which trend towards normative values with treatment, suggest increased fiber integrity in dorsal fronto-limbic pathways involved in mood regulation

Antiparasitic activity of chicory (Cichorium intybus) and its natural bioactive compounds in livestock: a review

Increasing drug resistance in gastrointestinal (GI) parasites of livestock and concerns about chemical residues in animal products and the environment are driving the development of alternative control strategies that are less reliant on the use of synthetic drugs. An increasingly investigated approach is the use of bioactive forages with antiparasitic properties as part of the animal’s diet (nutraceuticals) or as potential sources of novel, natural parasiticides. Chicory (Cichorium intybus) is a multi-purpose crop and one of the most promising bioactive forages in temperate regions, and numerous in vivo trials have explored its potential against parasitic nematodes in livestock. However, it is unclear whether chicory can induce a direct and broad activity against various GI parasites in different livestock species, and the levels of chicory in the diet that are required to exert an efficient antiparasitic effect. Moreover, the mechanisms leading to the reported parasiticidal activity of chicory are still largely unknown, and its bioactive phytochemicals have only recently been investigated. In this review, we summarise the progress in the study of the antiparasitic activity of chicory and its natural bioactive compounds against GI parasites in livestock, through examination of the published literature. The available evidence indicates that feeding chicory can reduce faecal egg counts and/or worm burdens of abomasal nematodes, but not infections with intestinal worms, in ruminants. Highly chicory-rich diets (≥ 70% of chicory dry matter in the diet) may be necessary to directly affect abomasal parasitism. Chicory is known to synthesise several bioactive compounds with potential antiparasitic activity, but most research has been devoted to the role of sesquiterpene lactones (SL). Recent in vitro studies have confirmed direct and potent activity of SL-rich extracts from chicory against different GI helminths of livestock. Chicory SL have also been reported to exhibit antimalarial properties and its potential antiprotozoal activity in livestock remains to be evaluated. Furthermore, the detailed identification of the main antiparasitic metabolites of chicory and their pharmacokinetics need further confirmation. Research gaps and perspectives on the potential use of chicory as a nutraceutical forage and a source of bioactive compounds for parasite control in livestock are discussed

Inter and intra-hemispheric structural imaging markers predict depression relapse after electroconvulsive therapy: a multisite study.

Relapse of depression following treatment is high. Biomarkers predictive of an individual's relapse risk could provide earlier opportunities for prevention. Since electroconvulsive therapy (ECT) elicits robust and rapidly acting antidepressant effects, but has a >50% relapse rate, ECT presents a valuable model for determining predictors of relapse-risk. Although previous studies have associated ECT-induced changes in brain morphometry with clinical response, longer-term outcomes have not been addressed. Using structural imaging data from 42 ECT-responsive patients obtained prior to and directly following an ECT treatment index series at two independent sites (UCLA: n = 17, age = 45.41±12.34 years; UNM: n = 25; age = 65.00±8.44), here we test relapse prediction within 6-months post-ECT. Random forests were used to predict subsequent relapse using singular and ratios of intra and inter-hemispheric structural imaging measures and clinical variables from pre-, post-, and pre-to-post ECT. Relapse risk was determined as a function of feature variation. Relapse was well-predicted both within site and when cohorts were pooled where top-performing models yielded balanced accuracies of 71-78%. Top predictors included cingulate isthmus asymmetry, pallidal asymmetry, the ratio of the paracentral to precentral cortical thickness and the ratio of lateral occipital to pericalcarine cortical thickness. Pooling cohorts and predicting relapse from post-treatment measures provided the best classification performances. However, classifiers trained on each age-disparate cohort were less informative for prediction in the held-out cohort. Post-treatment structural neuroimaging measures and the ratios of connected regions commonly implicated in depression pathophysiology are informative of relapse risk. Structural imaging measures may have utility for devising more personalized preventative medicine approaches

EURONU WP6 2009 yearly report: Update of the physics potential of Nufact, superbeams and betabeams

Many studies in the last ten years have shown that we can measure the unknown angle theta13, discover leptonic CP violation and determine the neutrino hierarchy in more precise neutrino oscillation experiments, searching for the subleading channel nue -> numu in the atmospheric range. In this first report of WP6 activities the following new results are reviewed: (1) Re-evaluation of the physics reach of the upcoming generation of experiments to measure theta13 and delta; (2) New tools to explore a larger parameter space as needed beyond the standard scenario; (3) Neutrino Factory: (a) evaluation of the physics reach of a Nufact regards sterile neutrinos; (b) evaluation of the physics reach of a Nufact as regards non-standard interactions; (c) evaluation of the physics reach of a Nufact as regards violation of unitarity; (d) critical assessment on long baseline tau-detection at Nufact; (e) new physics searches at a near detector in a Nufact; (4) Beta-beams: (a) choice of ions and location for a gamma = 100 CERN-based beta-beam; (b) re-evaluation of atmospheric neutrino background for the gamma = 100 beta-beam scenario; (c) study of a two baseline beta-beam; (d) measuring absolute neutrino mass with beta-beams; (e) progress on monochromatic beta-beams; (5) Update of the physics potential of the SPL super-beam. Eventually, we present an updated comparison of the sensitivity to theta13, delta and the neutrino mass hierarchy of several of the different proposed facilities.Comment: 2009 Yearly report of the Working Package 6 (Physics) of the EUROnu FP7 EU project. 55 pages, 21 figures

HERBVI - a program for simulation of baryon- and lepton- number violating processes

We describe a Monte Carlo event generator for the simulation of baryon- and lepton-number violating processes at supercolliders. The package, {\HERBVI}, is designed as a hard-process generator interfacing to the general hadronic event simulation program {\HW}. In view of the very high multiplicity of gauge bosons expected in such processes, particular attention is paid to the efficient generation of multiparticle phase space. The program also takes account of the expected colour structure of baryon-number violating vertices, which has important implications for the hadronization of the final state.Comment: 19 pages, standard LaTeX, no figure

Precision stellar radial velocity measurements with FIDEOS at the ESO 1-m telescope of La Silla

We present results from the commissioning and early science programs of FIDEOS, the new high-resolution echelle spectrograph developed at the Centre of Astro Engineering of Pontificia Universidad Catolica de Chile, and recently installed at the ESO 1m telescope of La Silla. The instrument provides spectral resolution R = 43,000 in the visible spectral range 420-800 nm, reaching a limiting magnitude of 11 in V band. Precision in the measurement of radial velocity is guaranteed by light feeding with an octagonal optical fibre, suitable mechanical isolation, thermal stabilisation, and simultaneous wavelength calibration. Currently the instrument reaches radial velocity stability of = 8 m/s over several consecutive nights of observation

The Mass-Radius Relationship for Very Low Mass Stars: Four New Discoveries from the HATSouth Survey

We report the discovery of four transiting F-M binary systems with companions between 0.1-0.2 Msun in mass by the HATSouth survey. These systems have been characterised via a global analysis of the HATSouth discovery data, combined with high-resolution radial velocities and accurate transit photometry observations. We determined the masses and radii of the component stars using a combination of two methods: isochrone fitting of spectroscopic primary star parameters, and equating spectroscopic primary star rotation velocity with spin-orbit synchronisation. These new very low mass companions are HATS550-016B (0.110 -0.006/+0.005 Msun, 0.147 -0.004/+0.003 Rsun), HATS551-019B (0.17 -0.01/+0.01 Msun, 0.18 -0.01/+0.01 Rsun), HATS551-021B (0.132 -0.005/+0.014 Msun, 0.154 -0.008/+0.006 Rsun), HATS553-001B (0.20 -0.02/+0.01 Msun, 0.22 -0.01/+0.01 Rsun). We examine our sample in the context of the radius anomaly for fully-convective low mass stars. Combining our sample with the 13 other well-studied very low mass stars, we find a tentative 5% systematic deviation between the measured radii and theoretical isochrone models.Comment: 17 pages, 8 figures, accepted for publication in MNRA

Measuring Dislocation Density in Aluminum with Resonant Ultrasound Spectroscopy

Dislocations in a material will, when present in enough numbers, change the speed of propagation of elastic waves. Consequently, two material samples, differing only in dislocation density, will have different elastic constants, a quantity that can be measured using Resonant Ultrasound Spectroscopy. Measurements of this effect on aluminum samples are reported. They compare well with the predictions of the theory.Comment: 4 pages, 2 figure

Negative time delay for wave reflection from a one-dimensional semi-harmonic well

It is reported that the phase time of particles which are reflected by a one-dimensional semi-harmonic well includes a time delay term which is negative for definite intervals of the incoming energy. In this interval, the absolute value of the negative time delay becomes larger as the incident energy becomes smaller. The model is a rectangular well with zero potential energy at its right and a harmonic-like interaction at its left.Comment: 6 pages, 5 eps figures. Talk presented at the XXX Workshop on Geometric Methods in Physics, Bialowieza, Poland, 201