Self modulated dynamics of a relativistic charged particle beam in plasma wake field excitation

Self modulated dynamics of a relativistic charged particle beam is reviewed within the context of the theory of plasma wake field excitation. The self-consistent description of the beam dynamics is provided by coupling the Vlasov equation with a Poisson-type equation relating the plasma wake potential to the beam density. An analysis of the beam envelope self-modulation is then carried out and the criteria for the occurrence of the instability are discussed thereby.Comment: This is a 10 pages manuscript which contain 4 figures. This manuscript is recently submitted in 'Nuclear Instruments and Methods in Physics Research Section A' as a proceeding of the conference 'EAAC 2015

Exosome-mediated Transfer of αvβ3 Integrin from Tumorigenic to Nontumorigenic Cells Promotes a Migratory Phenotype.

The αvβ3 integrin is known to be highly upregulated during cancer progression and promotes a migratory and metastatic phenotype in many types of tumors. We hypothesized that the αvβ3 integrin is transferred through exosomes and, upon transfer, has the ability to support functional aberrations in recipient cells. Here, for the first time, it is demonstrated that αvβ3 is present in exosomes released from metastatic PC3 and CWR22Pc prostate cancer cells. Exosomal β3 is transferred as a protein from donor to nontumorigenic and tumorigenic cells as β3 protein or mRNA levels remain unaffected upon transcription or translation inhibition in recipient cells. Furthermore, it is shown that upon exosome uptake, de novo expression of an αvβ3 increases adhesion and migration of recipient cells on an αvβ3 ligand, vitronectin. To evaluate the relevance of these findings, exosomes were purified from the blood of TRAMP mice carrying tumors where the expression of αvβ3 is found higher than in exosomes from wild-type mice. In addition, it is demonstrated that αvβ3 is coexpressed with synaptophysin, a biomarker for aggressive neuroendocrine prostate cancer. IMPLICATIONS: Overall this study reveals that the αvβ3 integrin is transferred from tumorigenic to nontumorigenic cells via exosomes, and its de novo expression in recipient cells promotes cell migration on its ligand. The increased expression of αvβ3 in exosomes from mice bearing tumors points to its clinical relevance and potential use as a biomarker. Mol Cancer Res; 14(11); 1136-46. ©2016 AACR

Connection between jets, winds and accretion in T Tauri stars: the X-shooter view

We have analysed the [OI]6300 A line in a sample of 131 young stars with discs in the Lupus, Chamaeleon and signa Orionis star forming regions, observed with the X-shooter spectrograph at VLT. The stars have mass accretion rates spanning from 10^{-12} to 10^{-7} Mo/yr. The line profile was deconvolved into a low velocity component (LVC, 40 km/s ), originating from slow winds and high velocity jets, respectively. The LVC is by far the most frequent component, with a detection rate of 77%, while only 30% of sources have a HVC. The [OI]6300 luminosity of both the LVC and HVC, when detected, correlates with stellar and accretion parameters of the central sources (i.e. Lstar , Mstar , Lacc , Macc), with similar slopes for the two components. The line luminosity correlates better with the accretion luminosity than with the stellar luminosity or stellar mass. We suggest that accretion is the main drivers for the line excitation and that MHD disc-winds are at the origin of both components. In the sub-sample of Lupus sources observed with ALMA a relationship is found between the HVC peak velocity and the outer disc inclination angle, as expected if the HVC traces jets ejected perpendicularly to the disc plane. Mass loss rates measured from the HVC span from ~ 10^{-13} to ~10^{-7} Mo/yr. The corresponding Mloss/Macc ratio ranges from ~0.01 to ~0.5, with an average value of 0.07. However, considering the upper limits on the HVC, we infer a ratio < 0.03 in more than 40% of sources. We argue that most of these sources might lack the physical conditions needed for an efficient magneto-centrifugal acceleration in the star-disc interaction region. Systematic observations of populations of younger stars, that is, class 0/I, are needed to explore how the frequency and role of jets evolve during the pre-main sequence phase.Comment: 15 pages, 14 figures, Accepted for publication in A&

Gaia DR2 view of the Lupus V-VI clouds: the candidate diskless young stellar objects are mainly background contaminants

Extensive surveys of star-forming regions with Spitzer have revealed populations of disk-bearing young stellar objects. These have provided crucial constraints, such as the timescale of dispersal of protoplanetary disks, obtained by carefully combining infrared data with spectroscopic or X-ray data. While observations in various regions agree with the general trend of decreasing disk fraction with age, the Lupus V and VI regions appeared to have been at odds, having an extremely low disk fraction. Here we show, using the recent Gaia data release 2 (DR2), that these extremely low disk fractions are actually due to a very high contamination by background giants. Out of the 83 candidate young stellar objects (YSOs) in these clouds observed by Gaia, only five have distances of 150 pc, similar to YSOs in the other Lupus clouds, and have similar proper motions to other members in this star-forming complex. Of these five targets, four have optically thick (Class II) disks. On the one hand, this result resolves the conundrum of the puzzling low disk fraction in these clouds, while, on the other hand, it further clarifies the need to confirm the Spitzer selected diskless population with other tracers, especially in regions at low galactic latitude like Lupus V and VI. The use of Gaia astrometry is now an independent and reliable way to further assess the membership of candidate YSOs in these, and potentially other, star-forming regions.Comment: Accepted for publication on Astronomy&Astrophysics Letter

Prediction of far-field acoustic emissions from cavitation clouds during shock wave lithotripsy for development of a clinical device

This study presents the key simulation and decision stage of a multi-disciplinary project to develop a hospital device for monitoring the effectiveness of kidney stone fragmentation by shock wave lithotripsy (SWL). The device analyses, in real time, the pressure fields detected by sensors placed on the patient's torso, fields generated by the interaction of the incident shock wave, cavitation, kidney stone and soft tissue. Earlier free-Lagrange simulations of those interactions were restricted (by limited computational resources) to computational domains within a few centimetres of the stone. Later studies estimated the far-field pressures generated when those interactions involved only single bubbles. This study extends the free-Lagrange method to quantify the bubble–bubble interaction as a function of their separation. This, in turn, allowed identification of the validity of using a model of non-interacting bubbles to obtain estimations of the far-field pressures from 1000 bubbles distributed within the focus of the SWL field. Up to this point in the multi-disciplinary project, the design of the clinical device had been led by the simulations. This study records the decision point when the project's direction had to be led by far more costly clinical trials instead of the relatively inexpensive simulations. <br/

X-Shooter study of accretion in Chamaeleon I: II. A steeper increase of accretion with stellar mass for very low mass stars?

The dependence of the mass accretion rate on the stellar properties is a key constraint for star formation and disk evolution studies. Here we present a study of a sample of stars in the Chamaeleon I star forming region carried out using the VLT/X-Shooter spectrograph. The sample is nearly complete down to M~0.1Msun for the young stars still harboring a disk in this region. We derive the stellar and accretion parameters using a self-consistent method to fit the broad-band flux-calibrated medium resolution spectrum. The correlation between the accretion luminosity to the stellar luminosity, and of the mass accretion rate to the stellar mass in the logarithmic plane yields slopes of 1.9 and 2.3, respectively. These slopes and the accretion rates are consistent with previous results in various star forming regions and with different theoretical frameworks. However, we find that a broken power-law fit, with a steeper slope for stellar luminosity smaller than ~0.45 Lsun and for stellar masses smaller than ~ 0.3 Msun, is slightly preferred according to different statistical tests, but the single power-law model is not excluded. The steeper relation for lower mass stars can be interpreted as a faster evolution in the past for accretion in disks around these objects, or as different accretion regimes in different stellar mass ranges. Finally, we find two regions on the mass accretion versus stellar mass plane empty of objects. One at high mass accretion rates and low stellar masses, which is related to the steeper dependence of the two parameters we derived. The second one is just above the observational limits imposed by chromospheric emission. This empty region is located at M~0.3-0.4Msun, typical masses where photoevaporation is known to be effective, and at mass accretion rates ~10^-10 Msun/yr, a value compatible with the one expected for photoevaporation to rapidly dissipate the inner disk.Comment: Accepted for publication on Astronomy & Astrophysics. Abstract shortened for arxiv constraints. Revised version after language editin

V1647 Orionis: One Year into Quiescence

We present new optical, near-IR, and mid-IR observations of the young eruptive variable star V1647 Orionis that went into outburst in late 2004 for approximately two years. Our observations were taken one year after the star had faded to its pre-outburst optical brightness and show that V1647Ori is still actively accreting circumstellar material. We compare and contrast these data with existing observations of the source from both pre-outburst and outburst phases. From near-IR spectroscopy we identify photospheric absorption features for the first time that allow us to constrain the classification of the young star itself. Our best fit spectral type is M0+-2 sub-classes with a visual extinction of 19+-2 magnitudes and a K-band veiling of rK~1.5+-0.2. We estimate that V1647Ori has a quiescent bolometric luminosity of ~9.5Lsun and a mass accretion rate of ~1.10^-6Msun yr^-1. Our derived mass and age, from comparison with evolutionary models, are 0.8+-0.2 Msun and ~0.5Myrs, respectively. The presence towards the star of shock excited optical [S II] and [Fe II] emission as well as near-IR H2 and [Fe II] emission perhaps suggests that a new Herbig-Haro flow is becoming visible close to the star.Comment: 22 pages, 19 Figures, accepted AJ 13 October 200

Statistical Theory for Incoherent Light Propagation in Nonlinear Media

A novel statistical approach based on the Wigner transform is proposed for the description of partially incoherent optical wave dynamics in nonlinear media. An evolution equation for the Wigner transform is derived from a nonlinear Schrodinger equation with arbitrary nonlinearity. It is shown that random phase fluctuations of an incoherent plane wave lead to a Landau-like damping effect, which can stabilize the modulational instability. In the limit of the geometrical optics approximation, incoherent, localized, and stationary wave-fields are shown to exist for a wide class of nonlinear media.Comment: 4 pages, REVTeX4. Submitted to Physical Review E. Revised manuscrip

Stability and collapse of localized solutions of the controlled three-dimensional Gross-Pitaevskii equation

On the basis of recent investigations, a newly developed analytical procedure is used for constructing a wide class of localized solutions of the controlled three-dimensional (3D) Gross-Pitaevskii equation (GPE) that governs the dynamics of Bose-Einstein condensates (BECs). The controlled 3D GPE is decomposed into a two-dimensional (2D) linear Schr\"{o}dinger equation and a one-dimensional (1D) nonlinear Schr\"{o}dinger equation, constrained by a variational condition for the controlling potential. Then, the above class of localized solutions are constructed as the product of the solutions of the transverse and longitudinal equations. On the basis of these exact 3D analytical solutions, a stability analysis is carried out, focusing our attention on the physical conditions for having collapsing or non-collapsing solutions.Comment: 21 pages, 14 figure