15,512 research outputs found
Multivariable Repetitive-predictive Controllers using Frequency Decomposition
Repetitive control is a methodology for the tracking of a periodic reference signal. This paper develops a new approach to repetitive control systems design using receding horizon control with frequency decomposition of the reference signal. Moreover, design and implementation issues for this form of repetitive predictive control are investigated from the perspectives of controller complexity and the effects of measurement noise. The analysis is supported by a simulation study on a multi-input multi-output robot arm where the model has been constructed from measured frequency response data, and experimental results from application to an industrial AC motor
Control of Coercivities in (Ga,Mn)As Thin Films by Small Concentrations of MnAs Nanoclusters
We demonstrate that low concentrations of a secondary magnetic phase in
(Ga,Mn)As thin films can enhance the coercivity by factors up to ~100 without
significantly degrading the Curie temperature or saturation magnetisation.
Magnetic measurements indicate that the secondary phase consists of MnAs
nanoclusters, of average size ~7nm. This approach to controlling the coercivity
while maintaining high Curie temperature, may be important for realizing
ferromagnetic semiconductor based devices.Comment: 8 pages,4 figures. accepted for publication in Appl. Phys. Let
Targeting lentiviral vectors to antigen-specific immunoglobulins
Gene transfer into B cells by lentivectors can provide an alternative approach to managing B lymphocyte malignancies and autoreactive B cell-mediated autoimmune diseases. These pathogenic B cell Populations can be distinguished by their surface expression of monospecific immunoglobulin. Development of a novel vector system to deliver genes to these specific B cells could improve the safety and efficacy of gene therapy. We have developed an efficient rnethod to target lentivectors to monospecific immunoglobulin-expressing cells in vitro and hi vivo. We were able to incorporate a model antigen CD20 and a fusogenic protein derived from the Sindbis virus as two distinct molecules into the lentiviral Surface. This engineered vector could specifically bind to cells expressing Surface immunoglobulin recognizing CD20 (αCD20), resulting in efficient transduction of target cells in a cognate antigen-dependent manner in vitro, and in vivo in a xenografted tumor model. Tumor suppression was observed in vivo, using the engineered lentivector to deliver a suicide gene to a xenografted tumor expressing αCD20. These results show the feasibility of engineering lentivectors to target immunoglobulin-specific cells to deliver a therapeutic effect. Such targeting lentivectors also Could potentially be used to genetically mark antigen-specific B cells in vivo to study their B cell biology
Resonant Cyclotron Radiation Transfer Model Fits to Spectra from Gamma-Ray Burst GRB870303
We demonstrate that models of resonant cyclotron radiation transfer in a
strong field (i.e. cyclotron scattering) can account for spectral lines seen at
two epochs, denoted S1 and S2, in the Ginga data for GRB870303. Using a
generalized version of the Monte Carlo code of Wang et al. (1988,1989b), we
model line formation by injecting continuum photons into a static
plane-parallel slab of electrons threaded by a strong neutron star magnetic
field (~ 10^12 G) which may be oriented at an arbitrary angle relative to the
slab normal. We examine two source geometries, which we denote "1-0" and "1-1,"
with the numbers representing the relative electron column densities above and
below the continuum photon source plane. We compare azimuthally symmetric
models, i.e. models in which the magnetic field is parallel to the slab normal,
with models having more general magnetic field orientations. If the bursting
source has a simple dipole field, these two model classes represent line
formation at the magnetic pole, or elsewhere on the stellar surface. We find
that the data of S1 and S2, considered individually, are consistent with both
geometries, and with all magnetic field orientations, with the exception that
the S1 data clearly favor line formation away from a polar cap in the 1-1
geometry, with the best-fit model placing the line-forming region at the
magnetic equator. Within both geometries, fits to the combined (S1+S2) data
marginally favor models which feature equatorial line formation, and in which
the observer's orientation with respect to the slab changes between the two
epochs. We interpret this change as being due to neutron star rotation, and we
place limits on the rotation period.Comment: LaTeX2e (aastex.cls included); 45 pages text, 17 figures (on 21
pages); accepted by ApJ (to be published 1 Nov 1999, v. 525
Integrating fluctuations into distribution of resources in transportation networks
We propose a resource distribution strategy to reduce the average travel time
in a transportation network given a fixed generation rate. Suppose that there
are essential resources to avoid congestion in the network as well as some
extra resources. The strategy distributes the essential resources by the
average loads on the vertices and integrates the fluctuations of the
instantaneous loads into the distribution of the extra resources. The
fluctuations are calculated with the assumption of unlimited resources, where
the calculation is incorporated into the calculation of the average loads
without adding to the time complexity. Simulation results show that the
fluctuation-integrated strategy provides shorter average travel time than a
previous distribution strategy while keeping similar robustness. The strategy
is especially beneficial when the extra resources are scarce and the network is
heterogeneous and lowly loaded.Comment: 14 pages, 4 figure
The effects of spatial constraints on the evolution of weighted complex networks
Motivated by the empirical analysis of the air transportation system, we
define a network model that includes geographical attributes along with
topological and weight (traffic) properties. The introduction of geographical
attributes is made by constraining the network in real space. Interestingly,
the inclusion of geometrical features induces non-trivial correlations between
the weights, the connectivity pattern and the actual spatial distances of
vertices. The model also recovers the emergence of anomalous fluctuations in
the betweenness-degree correlation function as first observed by Guimer\`a and
Amaral [Eur. Phys. J. B {\bf 38}, 381 (2004)]. The presented results suggest
that the interplay between weight dynamics and spatial constraints is a key
ingredient in order to understand the formation of real-world weighted
networks
On the influence of ram-pressure stripping on the star formation of simulated spiral galaxies
We investigate the influence of ram-pressure stripping on the star formation
and the mass distribution in simulated spiral galaxies. Special emphasis is put
on the question where the newly formed stars are located. The stripping radius
from the simulation is compared to analytical estimates. Disc galaxies are
modelled in combined N-body/hydrodynamic simulations (GADGET-2) with
prescriptions for cooling, star formation, stellar feedback, and galactic
winds. These model galaxies move through a constant density and temperature
gas, which has parameters comparable to the intra-cluster medium (ICM) in the
outskirts of a galaxy cluster (T=3 keV ~3.6x10^7 K and rho=10^-28 g/cm^3). With
this numerical setup we analyse the influence of ram-pressure stripping on the
star formation rate of the model galaxy. We find that the star formation rate
is significantly enhanced by the ram-pressure effect (up to a factor of 3).
Stars form in the compressed central region of the galaxy as well as in the
stripped gas behind the galaxy. Newly formed stars can be found up to hundred
kpc behind the disc, forming structures with sizes of roughly 1 kpc in diameter
and with masses of up to 10^7 M_sun. As they do not possess a dark matter halo
due to their formation history, we name them 'stripped baryonic dwarf'
galaxies. We also find that the analytical estimate for the stripping radius
from a Gunn & Gott (1972) criterion is in good agreement with the numerical
value from the simulation. Like in former investigations, edge-on systems lose
less gas than face-on systems and the resulting spatial distribution of the gas
and the newly formed stars is different.Comment: 8 pages, 7 figures, accepted for publication in A&
The Structure of the Star-forming Cluster RCW 38
We present a study of the structure of the high mass star-forming region
RCW~38 and the spatial distribution of its young stellar population. Spitzer
IRAC photometry 3-8um are combined with 2MASS near-IR data to identify young
stellar objects by IR-excess emission from their circumstellar material.
Chandra X-ray data are used to identify class III pre-main sequence stars
lacking circumstellar material. We identify 624 YSOs: 23 class 0/I and 90 flat
spectrum protostars, 437 Class II stars, and 74 Class III stars. We also
identify 29 (27 new) O star candidates over the IRAC field. Seventy-two stars
exhibit IR-variability, including seven class 0/I and 12 flat spectrum YSOs. A
further 177 tentative candidates are identified by their location in the IRAC
[3.6] vs. [3.6]-[5.8] cmd. We find strong evidence of subclustering in the
region. Three subclusters were identified surrounding the central cluster, with
massive and variable stars in each subcluster. The central region shows
evidence of distinct spatial distributions of the protostars and pre-main
sequence stars. A previously detected IR cluster, DB2001_Obj36, has been
established as a subcluster of RCW 38. This suggests that star formation in RCW
38 occurs over a more extended area than previously thought. The gas to dust
ratio is examined using the X-ray derived hydrogen column density, N_H and the
K-band extinction, and found to be consistent with the diffuse ISM, in contrast
with Serpens & NGC1333. We posit that the high photoionising flux of massive
stars in RCW 38 affects the agglomeration of the dust grains.Comment: 98 pages, 15 figure
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