An introduction to interactive sonification

The research field of sonification, a subset of the topic of auditory display, has developed rapidly in recent decades. It brings together interests from the areas of data mining, exploratory data analysis, human–computer interfaces, and computer music. Sonification presents information by using sound (particularly nonspeech), so that the user of an auditory display obtains a deeper understanding of the data or processes under investigation by listening

Dental erosion: In vitro model of wine assessor's erosion

The document attached has been archived with permission from the Australian Dental Association. An external link to the publisher’s copy is included.Background: Wine makers and assessors frequently experience severe dental erosion. The objectives of this study were to develop an in vitro model of dental erosion caused by frequent wine contact with teeth, and to use this model to assess the effectiveness of a variety of methods which might protect against this form of erosion. Methods: An initial pilot study found that riesling style wine was more erosive than champagne style, and both more than claret. Wine tasting was simulated by subjecting exposed windows of enamel and root surfaces on 50 intact, extracted human teeth to 1400 one minute exposures to white wine (pH 3.2). A variety of dental materials were applied to the exposed windows on groups of teeth prior to erosive challenge, to assess their protective ability. Results: Protective resin coatings and fluoride varnishes protected both enamel and roots against wine induced erosion. A high degree of protection was provided by APF gel, with less by NaF gel. Conclusions: It was concluded that dentists may be able to help minimise erosion resulting from frequent wine-tasting in their patients by the clinical application of one or a combination of these agents at times prior to prolonged assessment periods.Tong Bee Mok, J McIntyre and D Hun

(63)Cu NQR Evidence for Spatial Variation of Hole Concentration in La(2-x)Sr(x)CuO(4)

We report experimental evidence for the spatial variation of hole concentration x_(hole) in the high Tc superconductor La(2-x)Sr(x)CuO(4) (0.04 <= x <= 0.16) by using (63)Cu NQR for (63)Cu isotope enriched samples. We demonstrate that the extent of the spatial variation of the local hole concentration D(x)_(hole) is reflected on (63)1/T1 and deduce the temperature dependence. D(x)_(hole) increases below 500 - 600K, and reaches values as large as D(x)_(hole)/x ~ 0.5 below ~ 150K. We estimate the length scale of the spatial variation in x_(hole) to be R_(hole) >~ 3nm from analysis of the NQR spectrum.Comment: Accepted for publication in Physical Review Letter

Investigation of compounds essential for the origin of life

Nucleic acid sequencing as a technique to determine the chemical and biological evolution of certain prokaryotic metabolic pathways is discussed. Protein in data and a microbiological organization of the prokaryotes is included

Review study and evaluation of possible flight experiments relating to cloud physics experiments in space

The general objectives of the Zero-Gravity Atmospheric Cloud Physics Laboratory Program are to improve the level of knowledge in atmospheric cloud research by placing at the disposal of the terrestrial-bound atmospheric cloud physicist a laboratory that can be operated in the environment of zero-gravity or near zero-gravity. This laboratory will allow studies to be performed without mechanical, aerodynamic, electrical, or other techniques to support the object under study. The inhouse analysis of the Skylab 3 and 4 experiments in dynamics of oscillations, rotations, collisions and coalescence of water droplets under low gravity-environment is presented

Data-driven control design for neuroprotheses: a virtual reference feedback tuning (VRFT) approach

This paper deals with design of feedback controllers for knee joint movement of paraplegics using functional electrical stimulation (FES) of the paralyzed quadriceps muscle group. The controller design approach, virtual reference feedback tuning (VRFT), is directly based on open loop measured data and fits the controller in such a way that the closed-loop meets a model reference objective. The use of this strategy, avoiding the modeling step, significantly reduces the time required for controller design and considerably simplifies the rehabilitation protocols. Linear and nonlinear controllers have been designed and experimentally tested, preliminarily on a healthy subject and finally on a paraplegic patient. Linear controller is effective when applied on small range of knee joint angle. The design of a nonlinear controller allows better performances. It is also shown that the control design is effective in tracking assigned knee angle trajectories and rejecting disturbances

PID and PID-like controller design by pole assignment within D-stable regions

This paper presents a new PID and PID-like controller design method that permits the designer to control the desired dynamic performance of a closed-loop system by first specifying a set of desired D-stable regions in the complex plane and then running a numerical optimisation algorithm to find the controller parameters such that all the roots of the closed-loop system are within the specified regions. This method can be used for stable and unstable plants with high order degree, for plants with time delay, for controller with more than three design parameters, and for various controller configurations. It also allows a unified treatment of the controller design for both continuous and discrete systems. Examples and comparative simulation results are pro-vided to illustrate its merit

Exchange-Rate Risk Mitigation with Price-Level-Adjusting Mortgages: The Case of the Mexican UDI

In 1995, Mexico introduced a credit system based on a price-level-adjusting unit of account called the Unidad de Inversion (UDI, pronounced “oo-dee”), which is Spanish for “unit of investment.” The Bank of Mexico maintains an UDI Index, which sets the peso value of an UDI on any given day. Loans denominated in UDIs maintain their purchasing power and provide a real rate of return in the local currency, pesos. The focus of this study is the real rate of return earned by dollar investors in UDI mortgages. Most dollar investors fear exposure to exchange rate losses in unstable currencies. In this paper, we examine the real-dollar rate of return and the extent to which the inflation adjusting aspect of the UDI mitigates the losses from currency devaluations. We also examine exchange-rate patterns relative to purchasing-power-parity to find investment strategies that increase the real-dollar rate of return on investments in Mexico’s UDI mortgages.

Multilayered folding with voids

In the deformation of layered materials such as geological strata, or stacks of paper, mechanical properties compete with the geometry of layering. Smooth, rounded corners lead to voids between the layers, while close packing of the layers results in geometrically-induced curvature singularities. When voids are penalized by external pressure, the system is forced to trade off these competing effects, leading to sometimes striking periodic patterns. In this paper we construct a simple model of geometrically nonlinear multi-layered structures under axial loading and pressure confinement, with non-interpenetration conditions separating the layers. Energy minimizers are characterized as solutions of a set of fourth-order nonlinear differential equations with contact-force Lagrange multipliers, or equivalently of a fourth-order free-boundary problem. We numerically investigate the solutions of this free boundary problem, and compare them with the periodic solutions observed experimentally

PRDM14 is expressed in germ cell tumors with constitutive overexpression altering human germline differentiation and proliferation.

Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate. One recently identified susceptibility loci for human GCT is PR (PRDI-BF1 and RIZ) domain proteins 14 (PRDM14). PRDM14 is expressed in early primate PGCs and is repressed as PGCs differentiate. To examine PRDM14 in human GCTs we profiled human GCT cell lines and patient samples and discovered that PRDM14 is expressed in embryonal carcinoma cell lines, embryonal carcinomas, seminomas, intracranial germinomas and yolk sac tumors, but is not expressed in teratomas. To model constitutive overexpression in human PGCs, we generated PGC-like cells (PGCLCs) from human pluripotent stem cells (PSCs) and discovered that elevated expression of PRDM14 does not block early PGC formation. Instead, we show that elevated PRDM14 in PGCLCs causes proliferation and differentiation defects in the germline