Nel positively regulates the genesis of retinal ganglion cells by promoting their differentiation and survival during development

Peer reviewedPublisher PD

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum

Colloquy

Webster\u27s Dictionary defines colloquy as mutual discourse. Readers are encouraged to submit additions, corrections, and comments about earlier articles appearing in Word Ways. Comments received at least one month prior to publication of an issue will appear in that issue

An enhanced model for digital reference services

Digital Reference Service (DRS) play a vital role in the Digital Library (DL) research. DRS is a very valuable service provided by DL. Unfortunately, the reference service movement towards digital environment begins late, and this shift was not model based. So, a journey towards a digital environment without following a proper model raises some issues. A few researchers presented a general process model (GPM) in the late 1990s, but this process model could not overcome the problems of DRS. This paper proposes an enhanced model for DRS that use the storage and re-use mechanism with other vital components like DRS search engine and ready reference for solving the issues in DRS. Initially, storage and re-use mechanism are designed and finally, DRS search engine is designed to search appropriate answers in the knowledge base. We improved the GPM by incorporating the new components. The simulation results clearly states that the proposed model increased the service efficiency by reducing the response time from days to seconds for repeated questions and decreased the workload of librarian

Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism

7-carboxy-7-deazaguanine synthase (QueE) catalyzes a key S-adenosyl-L-methionine (AdoMet)- and Mg[superscript 2+]-dependent radical-mediated ring contraction step, which is common to the biosynthetic pathways of all deazapurine-containing compounds. QueE is a member of the AdoMet radical superfamily, which employs the 5′-deoxyadenosyl radical from reductive cleavage of AdoMet to initiate chemistry. To provide a mechanistic rationale for this elaborate transformation, we present the crystal structure of a QueE along with structures of pre- and post-turnover states. We find that substrate binds perpendicular to the [4Fe-4S]-bound AdoMet, exposing its C6 hydrogen atom for abstraction and generating the binding site for Mg[superscript 2+], which coordinates directly to the substrate. The Burkholderia multivorans structure reported here varies from all other previously characterized members of the AdoMet radical superfamily in that it contains a hypermodified ([β [subscript 6] over α [subscript 3]]) protein core and an expanded cluster-binding motif, CX[subscript 14]CX[subscript 2]C.United States. Dept. of Energy. Office of Biological and Environmental ResearchUnited States. Dept. of Energy. Office of Basic Energy SciencesNational Center for Research Resources (U.S.) (P41RR012408)National Institute of General Medical Sciences (U.S.) (P41GM103473)National Center for Research Resources (U.S.) (5P41RR015301-10)National Institute of General Medical Sciences (U.S.) (8 P41 GM 103403-10)United States. Dept. of Energy (Contract DE-AC02-06CH11357

Perspectives on Transitioning Uninsured Persons from an Emergency Department to Federally Qualified Health Centers in East Baltimore

Many people in the United States rely on the emergency department (ED) for their usual source of primary care. Linking these ED users to a source of longitudinal primary care could provide significant health benefits. To assess an intervention attempting to connect ED users to federally qualified health cents (FQHCs), we conducted semi-structured, in-depth interviews with volunteers, health facility providers, and a patient and a focus group with program volunteers. All sessions were digitally recorded, transcribed and analyzed to develop emergent themes highlighting the barriers and facilitating factors that affect the process of connecting patients to primary care. Themes included that 1) the ED is the preferred source of primary care over FQHCs, 2) there are limited links between EDs and FQHCs and 3) the evaluated intervention acts through and depends on patients’ prioritization of health and access to resources. Our findings suggest that, in addition to addressing individual needs, social services programs are well positioned to help increase communication between providers at FQHCs and EDs about both the services available to patients and patients’ medical care histories

44 Resistenzzüchtung / Widerstandsfähigkeit gegen Schadorganismen I

44-1 - Bewertung der Feldresistenz verschiedener Winterrapssorten gegenüber Verticillium longisporum mittels quantitativer PCRClassification of winter oilseed rape resistance towards the soilborne pathogen Verticillium longisporum by quantitative PCRJessica Knüfer, Daniel Teshome Lopisso, Birger Koopmann, Andreas von Tiedemann44-2 - Identification and characterization of three putative compatibility factor genes involved in the plant – Verticillium interactionIdentifikation und Charakterisierung drei putativer Kompatibilitätsfaktoren in der Pflanze – Verticillium InteraktionRoxana Hossain, Lisa Krapoth, Dirk Schenke, Daguang Cai44-3 - Impact of cultivar resistance to Verticillium longisporum on drought stress tolerance of winter oilseed rape (Brassica napus)Einfluss der Sortenresistenz gegen Verticillium longisporum auf die Trockenstresstoleranz von Winterraps (Brassica napus)Daniel Lopisso, Jessica Knüfer, Birger Koopmann, Andreas von Tiedemann44-4 - Wirksamkeit von Majorgenen in Raps gegenüber Phoma lingam unter Berücksichtigung steigender Temperaturen und des PathotypenspektrumsEfficacy of major genes in oilseed rape against Phoma lingam with regard to rising temperatures and the population structureMark Winter, Coretta Klöppel , Fadeke Fajemisin, Birger Koopmann44-5 - Anfälligkeit von Raps -Resynthesen und -Sorten auf den Rapsstängelrüssler (Ceutorhynchus napi Gyll.) Befall – potentielle ResistenzfaktorenSusceptibility of resynthesized lines and cultivars of oilseed rape on rape stem weevil (Ceutorhynchus napi Gyll.) infestation – potential plant traits responsible for resistanceHeike Schäfer-Kösterke, Bernd Ulber44-6 - Zweijähriges Rassen-Monitoring von Exserohilum turcicum in europäischen MaisanbaugebietenTwo-year race monitoring for Exserohilum turcicum in European maize growing regionsHendrik Hanekamp, Andreas von Tiedemann, Birger Koopmann44-7 - Smart breeding und Nutzung des Genpools von Wildarten zur Verbesserung der Krankheitsresistenz von KartoffelnSmart breeding and exploitation of the genepool from wild species for the improvement of disease resistance in potatoJanine König, Marion Nachtigall, Ramona Thieme, Jörg Schubert44-8 - Neue Ansätze für eine effizientere Resistenzzüchtung bei RebenNew approaches for increasing efficieny of grapevine resistance breedingRudolf Eibach, Reinhard Töpfe

Changes in the eruptive style of Stromboli Volcano before the 2019 paroxysmal phase discovered through SOM clustering of seismo-acoustic features compared with camera images and GBInSAR data

Two paroxysmal explosions occurred at Stromboli on 3 July and 28 August 2019, the first of which caused the death of a young tourist. After the first paroxysm an effusive activity began from the summit vents and affected the NW flank of the island for the entire period between the two paroxysms. We carried out an unsupervised analysis of seismic and infrasonic data of Strombolian explosions over 10 months (15 November 2018–15 September 2019) using a Self-Organizing Map (SOM) neural network to recognize changes in the eruptive patterns of Stromboli that preceded the paroxysms. We used a dataset of 14,289 events. The SOM analysis identified three main clusters that showed different occurrences with time indicating a clear change in Stromboli’s eruptive style before the paroxysm of 3 July 2019. We compared the main clusters with the recordings of the fixed monitoring cameras and with the Ground-Based Interferometric Synthetic Aperture Radar measurements, and found that the clusters are associated with different types of Strombolian explosions and different deformation patterns of the summit area. Our findings provide new insights into Strombolian eruptive mechanisms and new perspectives to improve the monitoring of Stromboli and other open conduit volcanoes