Regulating pacific seasonal labour in Australia

In 2008 the Australian government announced a new labour mobility scheme for Pacific workers, with the objectives of meeting seasonal demand for low-skilled labour in the horticulture industry and promoting economic development in Pacific Island countries. Modelled on New Zealand's Recognized Seasonal Employer scheme, it is a significant departure from Australia's long-standing preference for permanent migration that is non-discriminatory with respect to the country of origin. Any temporary migration program that draws a workforce from developing countries has the potential to exploit vulnerable foreign workers, but if Australia's pilot program is to be a success in the long term, it is imperative that seasonal workers from the Pacific are not exposed to that danger. This article examines the many layers of regulation that have been introduced to protect Pacific workers from exploitation, including bilateral intergovernmental agreements, supervision by government departments and use of external advisory bodies. In addition, Australia's regulatory framework governing workplace relations imposes a range of worker protections through equality laws, occupational health and safety principles, dispute settlement procedures and trade union involvement. To date, the Australian scheme has provided very limited opportunities for Pacific workers. This raises concerns about the long-term viability of this highly regulated scheme and the capacity to move beyond a pilot program to provide sustained opportunities for both Pacific workers and the horticulture industry.23 page(s

Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease

This work was supported by a research fellowship grant from the Crohn’s and Colitis in Childhood Research Association (CICRA) and a small project grant from Crohn’s and Colitis UK (CCUK). We would like to acknowledge Professor Ian Sanderson, who helped with the initial design of this work, and provided important support throughout. We would also like to thank Dr Gary Warne for his advice and assistance in the use of the sorting by flow cytometry. We would also like to thank Dr Raj Lahiri and Professor Graham Foster for the kind gift of the primers for the ISGs (2’5’ OAS and MxA)

Holocene sea level fluctuations and coastal evolution in the central Algarve (southern Portugal)

In Armação de Pêra Bay, southern Portugal, environmental changes during the Holocene can be interpreted based on the morphological and sedimentological similarities between older geomorphic features (cemented beach and dune rocks) and present coastal features. Using knowledge of the present beach and dune processes, we propose a two-step model for the evolution of Armação de Pêra Bay. First, during the rapid sea level rise between about 8800 and 6600 yr cal BP, the bay changed from a positive to a negative budget littoral cell and transgressive dunes formed, favoured by drought conditions. At about 5000 yr cal BP, during a sea level maximum, beach width was less than the critical fetch and dunes stabilized and underwent cementation during the wetter Atlantic climatic event. The second phase of dune accumulation started at about 3200 yr cal BP, due to a regression of sea level during which the bay changed back to a positive budget littoral cell in which beach width was greater than the critical fetch. Currently, the beach width is less than the critical fetch, dunes are inactive, and the sedimentary budget is negative due to sediment storage in local river systems.Fundação para a Ciência e a Tecnologia. FEDER, and OE (Project POCTI/CTA/34162/2000

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Protonophoric and mitochondrial uncoupling activity of aryl-carbamate substituted fatty acids.

Aryl-urea substituted fatty acids are protonophores and mitochondrial uncouplers that utilise a urea-based synthetic anion transport moiety to carry out the protonophoric cycle. Herein we show that replacement of the urea group with carbamate, a functional group not previously reported to possess anion transport activity, produces analogues that retain the activity of their urea counterparts. Thus, the aryl-carbamate substituted fatty acids uncouple oxidative phosphorylation and inhibit ATP production by collapsing the mitochondrial proton gradient. Proton transport proceeds via self-assembly of the deprotonated aryl-carbamates into membrane permeable dimeric species, formed by intermolecular binding of the carboxylate group to the carbamate moiety. These results highlight the anion transport capacity of the carbamate functional group

A secure fog-based platform for SCADA-based IoT critical infrastructure

© 2019 John Wiley & Sons, Ltd. The rapid proliferation of Internet of things (IoT) devices, such as smart meters and water valves, into industrial critical infrastructures and control systems has put stringent performance and scalability requirements on modern Supervisory Control and Data Acquisition (SCADA) systems. While cloud computing has enabled modern SCADA systems to cope with the increasing amount of data generated by sensors, actuators, and control devices, there has been a growing interest recently to deploy edge data centers in fog architectures to secure low-latency and enhanced security for mission-critical data. However, fog security and privacy for SCADA-based IoT critical infrastructures remains an under-researched area. To address this challenge, this contribution proposes a novel security “toolbox” to reinforce the integrity, security, and privacy of SCADA-based IoT critical infrastructure at the fog layer. The toolbox incorporates a key feature: a cryptographic-based access approach to the cloud services using identity-based cryptography and signature schemes at the fog layer. We present the implementation details of a prototype for our proposed secure fog-based platform and provide performance evaluation results to demonstrate the appropriateness of the proposed platform in a real-world scenario. These results can pave the way toward the development of a more secure and trusted SCADA-based IoT critical infrastructure, which is essential to counter cyber threats against next-generation critical infrastructure and industrial control systems. The results from the experiments demonstrate a superior performance of the secure fog-based platform, which is around 2.8 seconds when adding five virtual machines (VMs), 3.2 seconds when adding 10 VMs, and 112 seconds when adding 1000 VMs, compared to the multilevel user access control platform