4,711 research outputs found
Coordination in games with incomplete information: experimental results
We use experiments to study coordination in games with incomplete information and ask whether an informed player can use cheap talk strategically. Two players decide whether to enter a market where stage game payoffs either form a prisoner’s dilemma or a stag-hunt. One player knows which stage game is played while the other knows only the associated probabilities. When players engage in a prisoner’s dilemma each player prefers unilateral entry. When payoffs form a stag-hunt game, the outcome where neither enters Pareto dominates the outcome where both enter. We ask whether cheap talk aids coordination on the Pareto dominant outcome and whether the informed player can use cheap talk to engineer her preferred outcome. Consistent with previous literature, the benefit of cheap talk depends on the relationship between payoffs and risks. We find that cheap talk benefits informed players only when payoff risks are low. Key Words: cheap talk, coordination, experiments, incomplete information, risk dominance, payoff domiance
SpxA1 and SpxA2 act coordinately to fine-tune stress responses and virulence in Streptococcus pyogenes
SpxA is a unique transcriptional regulator highly conserved among members of the phylum Firmicutes that binds RNA polymerase and can act as an antiactivator. Why some Firmicutes members have two highly similar SpxA paralogs is not understood. Here, we show that the SpxA paralogs of the pathogen Streptococcus pyogenes, SpxA1 and SpxA2, act coordinately to regulate virulence by fine-tuning toxin expression and stress resistance. Construction and analysis of mutants revealed that SpxA1− mutants were defective for growth under aerobic conditions, while SpxA2− mutants had severely attenuated responses to multiple stresses, including thermal and oxidative stresses. SpxA1− mutants had enhanced resistance to the cationic antimicrobial molecule polymyxin B, while SpxA2− mutants were more sensitive. In a murine model of soft tissue infection, a SpxA1− mutant was highly attenuated. In contrast, the highly stress-sensitive SpxA2− mutant was hypervirulent, exhibiting more extensive tissue damage and a greater bacterial burden than the wild-type strain. SpxA1− attenuation was associated with reduced expression of several toxins, including the SpeB cysteine protease. In contrast, SpxA2− hypervirulence correlated with toxin overexpression and could be suppressed to wild-type levels by deletion of speB. These data show that SpxA1 and SpxA2 have opposing roles in virulence and stress resistance, suggesting that they act coordinately to fine-tune toxin expression in response to stress. SpxA2− hypervirulence also shows that stress resistance is not always essential for S. pyogenes pathogenesis in soft tissue
Delayed Slater determinant update algorithms for high efficiency quantum Monte Carlo
Within ab initio Quantum Monte Carlo simulations, the leading numerical cost
for large systems is the computation of the values of the Slater determinants
in the trial wavefunction. Each Monte Carlo step requires finding the
determinant of a dense matrix. This is most commonly iteratively evaluated
using a rank-1 Sherman-Morrison updating scheme to avoid repeated explicit
calculation of the inverse. The overall computational cost is therefore
formally cubic in the number of electrons or matrix size. To improve the
numerical efficiency of this procedure, we propose a novel multiple rank
delayed update scheme. This strategy enables probability evaluation with
application of accepted moves to the matrices delayed until after a
predetermined number of moves, K. The accepted events are then applied to the
matrices en bloc with enhanced arithmetic intensity and computational
efficiency via matrix-matrix operations instead of matrix-vector operations.
This procedure does not change the underlying Monte Carlo sampling or its
statistical efficiency. For calculations on large systems and algorithms such
as diffusion Monte Carlo where the acceptance ratio is high, order of magnitude
improvements in the update time can be obtained on both multi-core CPUs and
GPUs
Fuel cycles in nuclear reactors
Series numbering from publisher's list"61"--stamped on cover"Unclassified. NYO-2131."Originally issued by the first author as an Sc. D. thesis, Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 1959Contract AT(30-1)-207
Quadrupole collectivity beyond N=28: Intermediate-energy Coulomb excitation of 47,48Ar
We report on the first experimental study of quadrupole collectivity in the
very neutron-rich nuclei \nuc{47,48}{Ar} using intermediate-energy Coulomb
excitation. These nuclei are located along the path from doubly-magic Ca to
collective S and Si isotopes, a critical region of shell evolution and
structural change. The deduced transition strengths are confronted with
large-scale shell-model calculations in the shell using the
state-of-the-art SDPF-U and EPQQM effective interactions. The comparison
between experiment and theory indicates that a shell-model description of Ar
isotopes around N=28 remains a challenge.Comment: Accepted for publication in Physical Review Letters, typos fixed in
resubmission on April 1
Re-entrant ferroelectricity in liquid crystals
The ferroelectric (Sm C) -- antiferroelectric (Sm C) -- reentrant
ferroelectric (re Sm C) phase temperature sequence was observed for system
with competing synclinic - anticlinic interactions. The basic properties of
this system are as follows (1) the Sm C phase is metastable in temperature
range of the Sm C stability (2) the double inversions of the helix
handedness at Sm C -- Sm C and Sm C% -- re-Sm C phase
transitions were found (3) the threshold electric field that is necessary to
induce synclinic ordering in the Sm C phase decreases near both Sm
C -- Sm C and Sm C -- re-Sm C phase boundaries, and it has
maximum in the middle of the Sm C stability region. All these properties
are properly described by simple Landau model that accounts for nearest
neighboring layer steric interactions and quadrupolar ordering only.Comment: 10 pages, 5 figures, submitted to PR
Temperature dependence of binary and ternary recombination of H3+ ions with electron
We study binary and the recently discovered process of ternary He-assisted
recombination of H3+ ions with electrons in a low temperature afterglow plasma.
The experiments are carried out over a broad range of pressures and
temperatures of an afterglow plasma in a helium buffer gas. Binary and
He-assisted ternary recombination are observed and the corresponding
recombination rate coefficients are extracted for temperatures from 77 K to 330
K. We describe the observed ternary recombination as a two-step mechanism:
First, a rotationally-excited long-lived neutral molecule H3* is formed in
electron-H3+ collisions. Second, the H3* molecule collides with a helium atom
that leads to the formation of a very long-lived Rydberg state with high
orbital momentum. We present calculations of the lifetimes of H3* and of the
ternary recombination rate coefficients for para and ortho-H3+. The
calculations show a large difference between the ternary recombination rate
coefficients of ortho- and para-H3+ at temperatures below 300 K. The measured
binary and ternary rate coefficients are in reasonable agreement with the
calculated values.Comment: 15 page
Observation of mutually enhanced collectivity in self-conjugate Sr
The lifetimes of the first 2 states in the neutron-deficient
Sr isotopes were measured using a unique combination of the
-ray line-shape method and two-step nucleon exchange reactions at
intermediate energies. The transition rates for the 2 states were
determined to be (E2;2) = 2220(270) efm for
Sr and 1800(250) efm for Sr, corresponding to large
deformation of = 0.45(3) for Sr and 0.40(3) for Sr. The
present data provide experimental evidence for mutually enhanced collectivity
that occurs at = = 38. The systematic behavior of the excitation
energies and (E2) values indicates a signature of shape coexistence in
Sr, characterizing Sr as one of most deformed nuclei with an
unusually reduced (4)/(2) ratio.Comment: Accepted for publication in Physical Review C Rapid Communicatio
In-beam gamma-ray spectroscopy of 35Mg and 33Na
Excited states in the very neutron-rich nuclei 35Mg and 33Na were populated
in the fragmentation of a 38Si projectile beam on a Be target at 83 MeV/u beam
energy. We report on the first observation of gamma-ray transitions in 35Mg,
the odd-N neighbor of 34Mg and 36Mg, which are known to be part of the "Island
of Inversion" around N = 20. The results are discussed in the framework of
large- scale shell-model calculations. For the A = 3Z nucleus 33Na, a new
gamma-ray transition was observed that is suggested to complete the gamma-ray
cascade 7/2+ --> 5/2+ --> 3/2+ gs connecting three neutron 2p-2h intruder
states that are predicted to form a close-to-ideal K = 3/2 rotational band in
the strong-coupling limit.Comment: Accepted for publication Phys. Rev. C. March 16, 2011: Replaced
figures 3 and 5. We thank Alfredo Poves for pointing out a problem with the
two figure
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