Higher Derivative CP(N) Model and Quantization of the Induced Chern-Simons Term

We consider higher derivative CP(N) model in 2+1 dimensions with the Wess-Zumino-Witten term and the topological current density squared term. We quantize the theory by using the auxiliary gauge field formulation in the path integral method and prove that the extended model remains renormalizable in the large N limit. We find that the Maxwell-Chern-Simons theory is dynamically induced in the large N effective action at a nontrivial UV fixed point. The quantization of the Chern-Simons term is also discussed.Comment: 8 pages, no figure, a minor change in abstract, added Comments on the quantization of the Chern-Simons term whose coefficient is also corrected, and some references are added. Some typos are corrected. Added a new paragraph checking the equivalence between (3) and (5), and a related referenc

The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers.

G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factor-seven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on the surface of leukocytes. The EGF domains on the N-terminus add significant size to these receptors and they are considered to be among the largest members of the TM7 family. Although not all of their ligands or downstream targets have been identified, there is evidence implicating the EGF-TM7 family diverse processes such as cell adhesion, migration, inflammation, and autoimmune disease. Recent studies have identified expression of EGF-TM7 family members on human neoplasms including those of the thyroid, stomach, colon, and brain. Their presence on these tissues is not surprising given the ubiquity of GPCRs, but because their functional significance and pathways are not completely understood, they are of tremendous clinical and scientific interest. Current evidence suggests that expression of certain EGF-TM7 receptors is correlated with tumor grade, confers a more invasive phenotype, and increases the likelihood of metastatic disease. In this review, we will discuss the structure, function, and regulation of these receptors. We also describe the expression of these receptors in human cancers and explore their potential mechanistic significance

On the sign of the pi-rho-omega coupling constant

It is shown that the relative sign between the $NN\omega$ and $\pi\rho\omega$ coupling constants can be determined most sensitively from $\omega$ production processes in $NN$ collisions. Recent data on these reactions clearly favor the sign of the $\pi\rho\omega$ coupling constant which is opposite to that inferred from studies of the photoproduction reaction in combination with the vector meson dominance assumption and used by many authors. Implication of this finding in the description of other reactions is discussed.Comment: 6 pages, 4 figures, REVTeX, to be published in Phys. Lett.

Splanchnic vein thrombosis in myeloproliferative neoplasms: Pathophysiology and molecular mechanisms of disease

Myeloproliferative neoplasms (MPNs) are the most common underlying prothrombotic disorder found in patients with splanchnic vein thrombosis (SVT). Clinical risk factors for MPN-associated SVTs include younger age, female sex, concomitant hypercoagulable disorders, and the JAK2 V617F mutation. These risk factors are distinct from those associated with arterial or deep venous thrombosis (DVT) in MPN patients, suggesting disparate disease mechanisms. The pathophysiology of SVT is thought to derive from local interactions between activated blood cells and the unique splanchnic endothelial environment. Other mutations commonly found in MPNs, including CALR and MPL, are rare in MPN-associated SVT. The purpose of this article is to review the clinical and molecular risk factors for MPN-associated SVT, with particular focus on the possible mechanisms of SVT formation in MPN patients