Life remade: critical animation in the digital age

Introduction to Special Issue of animation: an interdisciplinary journal. Animation and contemporary life are enmeshed like never before. A growing number of the media images we consume are in animated form (from fully animated features to CGI laden blockbusters and advertisements); recourse to common animation software and aesthetic approaches significantly blur the lines between previously distinct artistic and design practices (from video games, to special effects, to architecture and contemporary art); and through techniques of computational modelling and visualization, animation is increasingly fundamental to processes of knowledge production and the creation of various modes or elements of life. This appears therefore to be a particularly 'critical' moment to ponder animation's expanded cultural and political role. This special issue also provides an opportunity to consider animation's own powers of critique – the ways in which the digital animated image is increasingly being deployed explicitly as a means of intervening in social and political arenas ranging from human rights advocacy to ecological activism. And finally, we hope this collection of essays serves to further the already rich examination of the politics of more traditional forms of animation in the current digital age. This special issue thus builds upon recent scholarship that has already begun to contend with animation's expanded presence and its inherent political and critical significance..

Heavy and light roles: myosin in the morphogenesis of the heart

Myosin is an essential component of cardiac muscle, from the onset of cardiogenesis through to the adult heart. Although traditionally known for its role in energy transduction and force development, recent studies suggest that both myosin heavy-chain and myosin lightchain proteins are required for a correctly formed heart. Myosins are structural proteins that are not only expressed from early stages of heart development, but when mutated in humans they may give rise to congenital heart defects. This review will discuss the roles of myosin, specifically with regards to the developing heart. The expression of each myosin protein will be described, and the effects that altering expression has on the heart in embryogenesis in different animal models will be discussed. The human molecular genetics of the myosins will also be reviewed