49 research outputs found
Concept and Experiences of Prototyping in a Software-Engineering-Environment with Natural
Studiengangsmodellierung - Ein implementierter Diskussionsansatz
Brune H, Carolla M, Spitta T. Studiengangsmodellierung - Ein implementierter Diskussionsansatz. WI-MAW Rundbrief. Vol 35. Bonn: GI e.V.; 2013.Dieses Papier skizziert das konzeptionelle Datenmodell einer Studiengangsmodellierung für Campus-Management-Systeme. Nach den ersten Pilotprojekten scheint dies ein Schlüsselproblem für die Standardisierung solcher Systeme zu sein. Das Modell beschränkt sich auf die Grunddaten von Studiengängen, wodurch prosaische Studienordnungen nicht berücksichtigt werden müssen. Die Darstellung erfolgt als Objektsicht mit Attributen und einer Beziehungssicht als UML Klassendiagramm. Vorhandene Implementierungen produktiver Systeme werden als Wissensbasis für die Validation des Modells benutzt
Ein verteiltes System im Rahmen einer zentralen Logistik - Konzept, Einführung und strategischer Ausbau
Popp T, Spitta T. Ein verteiltes System im Rahmen einer zentralen Logistik - Konzept, Einführung und strategischer Ausbau. In: Nagl M, ed. Online-Kongress Hamburg. Vol C635. Online-Kongress; 1997: 1-13
Extrastriatal dopamine D2/3 receptor availability in alcohol use disorder and individuals at high risk
Introduction: Reduced striatal dopamine D2/3 receptor availability in alcohol use disorder (AUD) has been demonstrated in recent clinical studies and meta-analyses. However, only a limited number of studies investigated extrastriatal D2/3 availability in AUD or in at-risk populations. In line with a dimensional understanding of addiction, extrastriatal dopaminergic neuroadaptations have been suggested to be relevant from a pathobiological perspective.
Methods: We investigated D2/3 receptor availability via F-18-fallypride positron emission tomography applying a region of interest (ROI) approach. We selected ROIs for the prefrontal cortex (PFC) and the anterior cingulate cortex (ACC). Our sample included 19 healthy controls (low risk [LR]), 19 individuals at high risk (HR) to develop addiction, and 20 recently detoxified AUD patients.
Results: We found significantly higher D2/3 receptor availability of HR compared to AUD in the left and right rostral ACC (rACC), as well as in the left ventrolateral PFC (vlPFC). We did not observe a significant difference between AUD and LR. After corrections for multiple comparisons none of the ROIs reached significance throughout the group comparison. The D2/3 receptor availability in the left rACC was inversely correlated with symptom severity assessed with the Alcohol Dependency Scale.
Discussion: To our knowledge, the present work is the first study investigating extrastriatal D2/3 receptor availabilities in individuals at HR and patients with AUD. The observation that D2/3 receptor availabilities are highest in HR might suggest that their pathobiology differs from subjects with AUD. Future studies are necessary to clarify the intraindividual course of this biomarker over different disease stages and its possible role as a risk or protective factor
