LOW-LEVEL LASER THERAPY: ENHANCING SURGICAL OUTCOME OF CORONALLY ADVANCED FLAP OUTCOMES FOR ISOLATED GINGIVAL RECESSION

Background: Gingival recession is a common issue that can impact how your smile looks and your oral health. The coronally advanced flap (MCAF) is a surgical procedure to treat gingival recession and enhance the esthetics. This procedure is often combined with low level laser therapy (LLLT) which is believed to enhance overall treatment results. Objective: The goal of this research was to assess how effective LLLT is when used alongside MCAF in decreasing the depth and width of recession and improving the clinical attachment level within a span of 6 months. Methods: Twenty patients, with Miller Class I or II gingival recession defects were divided into two groups -one receiving MCAF alone and the other receiving MCAF along with LLLT treatment in a randomized manner. The clinical measurements of GRD (gingival recession depth) GRW (gingival recession width) and CAL (attachment level) were evaluated at the beginning of the study and at the 3 month and 6-month marks to evaluate the progress. The results, between the two groups were compared and statistically analyzed.Results: Both groups had same values, for GRD and GRW measurements initially. By month 3 of observation period the experimental group exhibited significant decreases in GRD (0.40 ± 0.35 mm vs. 1.10 ± 0.50 mm; p = 0.01) and GRH (0.50 ± 0.30 mm vs. 1.20 ± 0.60 mm; p = 0.002). The enhancements persisted after 6 months showing that those, in test group achieved results for gingival recession depth (0.50 ± 0.25 mm vs. 1.60 ± 0.45 mm; p = 0.001) as well as gingival recession width (0.60 ± 0.35 mm vs. 1.70 ± 0.55 mm; p = 0.001). The test group also experienced improvement, in clinical attachment level gain during both follow up periods. Conclusion: Low Level Laser Therapy (LLLT) greatly improves the results of MCAF procedure by decreasing Gingival Recession Depth (GRD) and Gingival Recession Width (GRW) while improvement in clinical Attachment Level (CAL) during the 6 months post treatment follow up. Thus, the incorporation of LLLT, in the treatment of gingival recession may be considered

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1

Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis is the myofibroblast, and fibroblast to myofibroblast differentiation is probably a crucial event. The cytokine TGF-β1 is reportedly the most important regulator of myofibroblastic differentiation in other species. The aim of this study was to isolate and characterise renal fibroblasts from cadaverous kidney tissue of cats with and without CKD, and to investigate the transcriptional response to TGF-β1

Conceivable security risks and authentication techniques for smart devices

With the rapidly escalating use of smart devices and fraudulent transaction of users’ data from their devices, efficient and reliable techniques for authentication of the smart devices have become an obligatory issue. This paper reviews the security risks for mobile devices and studies several authentication techniques available for smart devices. The results from field studies enable a comparative evaluation of user-preferred authentication mechanisms and their opinions about reliability, biometric authentication and visual authentication techniques

Correlation of lipid profile and anthropometry with aortic intima-media thickness in newborns of diabetic and non-diabetic mothers

Background: Exposure to diabetes in utero has been established as a significant factor for certain component of the clinical syndrome. Although complications of atherosclerosis occur in adult life, the process begins in early childhood. Hence, measuring aortic intima-media thickness (AIMT) in the newborn is a feasible, accurate, and sensitive marker of atherosclerotic risk. Objective: The objective of the study was to find an association of AIMT with cord blood lipid levels and anthropometric factors. Methods: Babies born to diabetic mothers (gestational diabetes mellitus/type 2 diabetes mellitus (34 weeks–42 weeks) who were taken as one group and babies born to non-diabetic mothers (34 weeks–42 weeks) who were taken as the other group were enrolled in this study. Lipid values were measured of umbilical cord blood, collected immediately after delivery. Atherogenic-indices were calculated; neonatal anthropometric measurements were taken within 24 h after delivery. Abdominal AIMT (aAIMT) was measured within 4 days of delivery using a high-resolution ultrasound B mode by a trained radiologist. Maternal age, parity, height, pre-pregnancy weight, gestational age, and other investigations were taken from maternal records. Results: In this study, birth weight (BW) was positively correlated with triglycerides (TG), cholesterol, high-density lipoprotein (HDL), very low-density lipoprotein (VLDL), and atherogenic-indices, whereas, it was negatively correlated with low-density lipoprotein (LDL) (p<0.01). A positive correlation was found between aAIMT and BW, abdominal circumference, TG, cholesterol, HDL, LDL, VLDL, and atherogenic-indices (p<0.001). Conclusions: In this study, infants born to diabetic mothers had higher anthropometry, lipid values, aAIMT compared to babies born to non-diabetic mothers without risk factors

Cortical bone architecture of hominid intermediate phalanges reveals functional signals of locomotion and manipulation

Abstract Objectives Reconstruction of fossil hominin manual behaviors often relies on comparative analyses of extant hominid hands to understand the relationship between hand use and skeletal morphology. In this context, the intermediate phalanges remain understudied. Thus, here we investigate cortical bone morphology of the intermediate phalanges of extant hominids and compare it to the cortical structure of the proximal phalanges, to investigate the relationship between cortical bone structure and inferred loading during manual behaviors. Materials and Methods Using micro-CT data, we analyze cortical bone structure of the intermediate phalangeal shaft of digits 2?5 in Pongo pygmaeus (n?=?6 individuals), Gorilla gorilla (n?=?22), Pan spp. (n?=?23), and Homo sapiens (n?=?23). The R package morphomap is used to study cortical bone distribution, cortical thickness and cross-sectional properties within and across taxa. Results Non-human great apes generally have thick cortical bone on the palmar shaft, with Pongo only having thick cortex on the peaks of the flexor sheath ridges, while African apes have thick cortex along the entire flexor sheath ridge and proximal to the trochlea. Humans are distinct in having thicker dorsal shaft cortex as well as thick cortex at the disto-palmar region of the shaft. Discussion Variation in cortical bone distribution and properties of the intermediate phalanges is consistent with differences in locomotor and manipulative behaviors in extant great apes. Comparisons between the intermediate and proximal phalanges reveals similar patterns of cortical bone distribution within each taxon but with potentially greater load experienced by the proximal phalanges, even in knuckle-walking African apes. This study provides a comparative context for the reconstruction of habitual hand use in fossil hominins and hominids

Cortical bone distribution of the proximal phalanges in great apes: Implications for reconstructing manual behaviours

Primate fingers are typically in direct contact with the environment during both locomotion and manipulation, and aspects of external phalangeal morphology are known to reflect differences in hand use. Since bone is a living tissue that can adapt in response to loading through life, the internal bone architecture of the manual phalanges should also reflect differences in manual behaviours. Here, we use the R package Morphomap to analyse high-resolution microCT scans of hominid proximal phalanges of digits 2–5 to determine whether cortical bone structure reflects variation in manual behaviours between bipedal (Homo), knuckle-walking (Gorilla, Pan) and suspensory (Pongo) taxa. We test the hypothesis that relative cortical bone distribution patterns and cross-sectional geometric properties will differ both among extant great apes and across the four digits due to locomotor and postural differences. Results indicate that cortical bone structure reflects the varied hand postures employed by each taxon. The phalangeal cortices of Pongo are significantly thinner and have weaker cross-sectional properties relative to the African apes, yet thick cortical bone under their flexor sheath ridges corresponds with predicted loading during flexed finger grips. Knuckle-walking African apes have even thicker cortical bone under the flexor sheath ridges, as well as in the region proximal to the trochlea, but Pan also has thicker diaphyseal cortices than Gorilla. Humans display a distinct pattern of distodorsal thickening, as well as relatively thin cortices, which may reflect the lack of phalangeal curvature combined with frequent use of flexed fingered hand grips during manipulation. Within each taxon, digits 2–5 have a similar cortical distribution in Pongo, Gorilla and, unexpectedly, Homo, which suggest similar loading of all fingers during habitual locomotion or hand use. In Pan, however, cortical thickness differs between the fingers, potentially reflecting differential loading during knuckle-walking. Inter- and intra-generic variation in phalangeal cortical bone structure reflects differences in manual behaviours, offering a comparative framework for reconstructing hand use in fossil hominins. © 2023 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society.<br

Assessment of Neuropharmacological Profile of Ethanolic Extract of Lawsonia Inermis Flowers

On preliminary basis neuropharmacological profile of ethanolic extract of flowers of Lawsonia inermis was carried out. For assessing the activity of flowers on central nervous system locomotor activity using actophotometer, muscle relaxant activity using rotarod apparatus, pentobarbital-induced hypnosis and anticonvulsant activity by maximal electroshock test was performed.&nbsp; Ethanolic extract of flowers of Lawsonia inermis decreased the motor activity by 48.63 % and showed 49.03% noteworthy muscle relaxation along with 127.73% potentiation of pentobarbital-induced sleeping time and 66.67% decreased the duration of tonic hind leg extension of seizures activity. &nbsp;The results conclude that the extract of flowers of Lawsonia inermis has significant central nervous system depressant activity. Further investigations are, however, necessary to explore mechanism(s) of action involved in these pharmacological activities

Syntheses and crystal structures of mixed-ligand copper(II)–imidazole–carboxylate complexes

Crystallographic data for the structures in this paper have been deposited with the Cambridge Crystallographic Data Center, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK. Copies of the data can be obtained free of charge on quoting depository numbers CCDC-1543434 (1), CCDC-1543435 (2) and CCDC-1543436 (3) (Fax:+44-1223-336–033; E-mail: [email protected]; http://www.ccdc.cam.ac.uk). Supplemental data for this article can be accessed at https://doi.org/10.1080/00958972.2018.1460471.Peer reviewedPostprin

Churg Strauss Syndrome – Case Report

We report a 49 year old male patient who presented with swelling in both thighs without pain and dyspnea. Platelet count was low (13,000/mm3) with increased eosinophils (48.9%). Patient developed pulmonary embolism. His ADAMTS 13 level was low and was therefore diagnosed as TTP. Treatment given was corticosteroid and plasma exchange. After a year he developed a lump in the skull. Histopathology report revealed vasculitis. Due to presence of vasculitis (TTP) along with eosinophilia, patient was finally diagnosed as a case of Churg Strauss Syndrome (CSS)

Development and Validation of Analytical Method for Losartan-Copper Complex Using UV-Vis Spectrophotometry

Purpose: To develop a new spectrophotometric method for the analysis of losartan potassium in pharmaceutical formulations by making its complex with copper.Method: A coloured complex based on UV/Vis spectroscopic method was developed for the determination of losartan potassium concentration in pharmaceutical formulations in the visible region. The colored complex of losartan was formed with cupric acetate (5:4). Analysis was carried out by the two methods - absorption ratio and calibration curve methods. The proposed method was validated in terms of linearity, accuracy and precision.Results: The λ maximum of the complex was recorded at 530 nm. Beer`s law was obeyed in the range of 10 - 50 μg/ml with a correlation coefficient (r2) of 0.9989. Mean analytical results from the calibration curve and absorption ratio methods were 99.42 and 99.16 % with relative standard deviation (RSD) of 0.97 and 0.82 %, respectively. Mean recovery was between 98.61 and 101.35 % and precision expressed as relative standard deviation (RSD) was 0.91 %.Conclusion: The proposed method is simple, easy to apply, low-cost, and requires relatively inexpensive instruments. Thus, it is a suitable alternative to currently used spectrophotometric methods for the determination of losartan in bulk and solid dosage forms.Keywords: Losartan, Copper complex, Spectrophotometry, Validatio