Increased rate of acceleration on Pine Island Glacier strongly coupled to changes in gravitational driving stress

Peer reviewe

Discovery and Orbital Determination of the Transient X-ray Pulsar GRO J1750-27

We report on the discovery and hard X-ray (20-70 keV) observations of the 4.45 s period transient X-ray pulsar GRO J1750-27 with the BATSE all-sky monitor on board CGRO. A relatively faint outburst (<30 mcrab peak) lasting at least 60 days was observed during which the spin-up rate peaked at 38 pHz s^(-1) and was correlated with the pulsed intensity. An orbit with a period of 29.8 days was found. The large spin-up rate, spin period, and orbital period together suggest that accretion is occurring from a disk and that the outburst is a "giant" outburst typical of a Be/X-ray transient system. No optical counterpart has yet been reported

Torque Reversal and Spin-Down of the Accretion-Powered Pulsar 4U 1626-67

Over 5 yr of hard X-ray (20-60 keV) monitoring of the 7.66 s accretion-powered pulsar 4U 1626-67 with the Compton Gamma Ray Observatory/BATSE large-area detectors has revealed that the neutron star is now steadily spinning down, in marked contrast to the steady spin-up observed during 1977-1989. This is the second accreting pulsar (the other is GX 1+4) that has shown extended, steady intervals of both spin-up and spin-down. Remarkably, the magnitudes of the spin-up and spin-down torques differ by only 15%, with the neutron star spin changing on a timescale |ν/dot ν| ≈ 5000 yr in both states. The current spin-down rate is itself decreasing on a timescale |dot ν/bar ν| ≈ 26 yr. The long-term timing history shows small-amplitude variations on a 4000 day timescale, which are probably due to variations in the mass transfer rate. The pulsed 20-60 keV emission from 4U 1626-67 is well-fitted by a power-law spectrum with photon index γ = 4.9 and a typical pulsed intensity of 1.5 × 10^(-10) ergs cm^(-2) s^(-1). The low count rates with BATSE prohibited us from constraining the reported 42 minute binary orbit, but we can rule out long-period orbits in the range 2 days lesssim Porb lesssim 900 days. We compare the long-term torque behavior of 4U 1626-67 to other disk-fed accreting pulsars and discuss the implications of our results for the various theories of magnetic accretion torques. The abrupt change in the sign of the torque is difficult to reconcile with the extremely smooth spin-down now observed. The strength of the torque noise in 4U 1626-67, ~10^(-22) Hz^2 s^(-2) Hz^(-1), is the smallest ever measured for an accreting X-ray pulsar, and it is comparable to the timing noise seen in young radio pulsars. We close by pointing out that the core temperature and external torque (the two parameters potentially relevant to internal sources of timing noise) of an accreting neutron star are also comparable to those of young radio pulsars

On generating functions in additive number theory, II: Lower-order terms and applications to PDEs

We obtain asymptotics for sums of the form $$\sum_{n=1}^P e(\alpha_kn^k + \alpha_1n),$$ involving lower order main terms. As an application, we show that for almost all $\alpha_2 \in [0,1)$ one has $$\sup_{\alpha_1 \in [0,1)} \Big| \sum_{1 \le n \le P} e(\alpha_1(n^3+n) + \alpha_2 n^3) \Big| \ll P^{3/4 + \varepsilon},$$ and that in a suitable sense this is best possible. This allows us to improve bounds for the fractal dimension of solutions to the Schr\"odinger and Airy equations

Tourism as connectedness.

Late modernity in developed nations is characterized by changing social and psychological conditions, including individualization, processes of competition and loneliness. Remaining socially connected is becoming increasingly important. In this situation, travel provides meaning through physical encounters, inclusion in traveller Gemeinschaft based on shared norms, beliefs and interests, and social status in societies increasingly defined by mobilities. As relationships are forged and found in mobility, travel is no longer an option, rather a necessity for sociality, identity construction, affirmation or alteration. Social contexts and the underlying motivations for tourism have changed fundamentally in late modernity: non-tourism has become a threat to self-conceptions. By integrating social and psychological perspectives, this paper expands and deepens existing travel and mobilities discussions to advance the understanding of tourism as a mechanism of social connectedness, and points to implications for future tourism research

The effect of physical activity on psychological distress, cortisol and obesity: results of the farming fit intervention program

Background:Rural and regional Australians have a higher likelihood of mental illness throughout their lifetime than people living in major cities, although the underlying reasons are not yet well defined. Additionally, rural populations experience more lifestyle associated co-morbidities including obesity, diabetes and cardiovascular disease. Research conducted by the National Centre for Farmer Health between 2004 and 2009 revealed a positive correlation between obesity and psychological distress among the farming community. Chronic stress is known to overstimulate the regulation of the hypothalamic-pituitary-adrenal (HPA) axis and cortisol secretion which are associated with abdominal adiposity. Increasing physical activity may normalise cortisol secretion and thereby positively impact both physical and mental health. This paper assesses the effects of increasing physical activity on obesity, health behaviors and mental health in Victorian farming men and women.Methods:Farming Fit was a six month quasi-experimental (convenience sample) longitudinal design control-intervention study. Overweight or obese (BMI ?25?kg/m2) farm men (n?=?43) and women (n?=?29) were recruited with demographic, health behaviors, anthropometric, blood pressure and biochemistry data collected at baseline and at a six months. Salivary cortisol and depression anxiety stress scale results were collected at baseline, three and six months. The intervention group (n?=?37) received a personalized exercise program and regular phone coaching to promote physical activity.Results:The intervention group showed significant reductions in body weight and waist circumference. Results indicated that following the six month exercise program, the intervention group were 2.64???0.65?kg lighter (p?&lt;?0.001), had reduced waist circumference by 2.01???0.86?cm (p?=?0.02) and BMI by 0.97???0.22?kg/m2 (p?&lt;?0.001) relative to the control group.Conclusion:Increasing physical activity altered measures of obesity in farm men and women but did not affect mental health measures or cortisol secretion levels

Prospectus, September 24, 1980

RODNEY DANGERFIELD GETS SOME RESPECT FROM PC; PCF group greets newcomers; Parkland offers COSMOS telecourse; Clerks to be on campus to register voters; Women\u27s Program discusses importance of adequate diet; Breakdown of budget: Where does all your money go?; Women\u27s Program presents last of self-care series; Parkland College Board of Trustees meets; Members needed; A friend is someone who...; Family Life Program offers Living in Step ; Chimera Inc. offers workshop; PACT presents seminar for expectant parents; Steve Goodman: A talented performer; The Ducks have a good time; Rodney Dangerfield: I don\u27t get no respect; He will always get respect in Champaign-Urbana ; Francis named Outstanding Young Men of America ; Eisner to hold celebration; Classifieds; Showcase and workshop Oct. 8; PACT presents program: Early childhood; Volleyballers win two; Upsets spoil Fast Freddy; All you lost freshman-- pay attention to this story; Fast Freddy Contesthttps://spark.parkland.edu/prospectus_1980/1020/thumbnail.jp

The European Transdisciplinary Assessment of Climate Engineering (EuTRACE): Removing Greenhouse Gases from the Atmosphere and Reflecting Sunlight away from Earth

The European Transdisciplinary Assessment of Climate Engineering (EuTRACE): Removing Greenhouse Gases from the Atmosphere and Reflecting Sunlight away from Eart

<i>ABCB1</i> (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells

BACKGROUND: Clinical response to chemotherapy for ovarian cancer is frequently compromised by the development of drug-resistant disease. The underlying molecular mechanisms and implications for prescription of routinely prescribed chemotherapy drugs are poorly understood. METHODS: We created novel A2780-derived ovarian cancer cell lines resistant to paclitaxel and olaparib following continuous incremental drug selection. MTT assays were used to assess chemosensitivity to paclitaxel and olaparib in drug-sensitive and drug-resistant cells±the ABCB1 inhibitors verapamil and elacridar and cross-resistance to cisplatin, carboplatin, doxorubicin, rucaparib, veliparib and AZD2461. ABCB1 expression was assessed by qRT-PCR, copy number, western blotting and immunohistochemical analysis and ABCB1 activity assessed by the Vybrant and P-glycoprotein-Glo assays. RESULTS: Paclitaxel-resistant cells were cross-resistant to olaparib, doxorubicin and rucaparib but not to veliparib or AZD2461. Resistance correlated with increased ABCB1 expression and was reversible following treatment with the ABCB1 inhibitors verapamil and elacridar. Active efflux of paclitaxel, olaparib, doxorubicin and rucaparib was confirmed in drug-resistant cells and in ABCB1-expressing bacterial membranes. CONCLUSIONS: We describe a common ABCB1-mediated mechanism of paclitaxel and olaparib resistance in ovarian cancer cells. Optimal choice of PARP inhibitor may therefore limit the progression of drug-resistant disease, while routine prescription of first-line paclitaxel may significantly limit subsequent chemotherapy options in ovarian cancer patients

The blameworthiness of health and safety rule violations

Man-made disasters usually lead to the tightening of safety regulations, because rule breaking is seen as a major cause of them. This reaction is based on the presumptions that the safety rules are good and that the rule-breakers are wrong. The reasons the personnel of a coke factory gave for breaking rules raise doubt about the tenability of these presumptions. It is unlikely that this result would have been achieved on the basis of a disaster evaluation or High-Reliability Theory. In both approaches, knowledge of the consequences of human conduct hinders an unprejudiced judgement about the blameworthiness of rule breaking