Gastrointestinal Stromal Tumors (GIST)

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, occurring predominantly in the stomach and small intestine. These tumors account for up to 3% of all gastrointestinal malignancies, with a reported annual incidence of 10–15 cases per million population. GISTs are thought to originate from interstitial cells of Cajal (ICC) or ICC precursor cells, and are characterized by activating mutations in the KIT (CD117) and platelet-derived growth factor receptor alpha (PDGFRα) proto-oncogenes in 85–95% of all cases. The clinical presentation and tumor biology of GISTs are widely variable, with several advances being made over the past two decades in the understanding of GIST tumor biology and pathophysiology. This has led to a paradigm shift in management from the purely surgical approach of the past, to a multi-modality treatment strategy with a greater role for targeted therapies in the form of tyrosine kinase inhibitors, resulting in significantly improved patient outcomes

When are net effects gross products? The power of influence and the influence of power in computer-mediated communication.

The rush to judgment about the social effects of the new communications media has branded them as positive and negative in equal measure. Alienation from "real world" relationships coupled with a lack of social regulation within the medium is balanced by liberation from the influences, inequalities, and identities to which people are subjected in face-to-face interaction. We argue that such general conclusions may in fact be turned upside down and propose that these media may actually strengthen social bonds but also reinforce power inequalities. Reviewing evidence of our research with university students, employing the social identity model of deindividuation effects, we show how these technologies can often be more "social," and socially regulated, than face-to-face interaction