Effect of Adiabatic Phonons on Striped and Homogeneous Ground States

The effects of adiabatic phonons on a spin-fermion model for high T_c cuprates are studied using numerical simulations. In the absence of electron-phonon interactions (EPI), stripes in the ground state are observed for certain dopings while homogeneous states are stabilized in other regions of parameter space. Different modes of adiabatic phonons are added to the Hamiltonian:breathing, shear and half-breathing modes. Diagonal and off-diagonal electron-phonon couplings are considered. It is observed that strong diagonal EPI generate stripes in previously homogeneous states, while in striped ground states an increase in the diagonal couplings tends to stabilize the stripes, inducing a gap in the density of states (DOS) and rendering the ground state insulating. The off-diagonal terms, on the other hand, destabilize the stripes creating inhomogeneous ground states with a pseudogap at the chemical potential in the DOS. The breathing mode stabilizes static diagonal stripes; while the half-breathing (shear) modes stabilize dynamical (localized) vertical and horizontal stripes. The EPI induces decoherence of the quasi-particle peaks in the spectral functions.Comment: latex, 9 pages,13 figure

Impact of facial conformation on canine health: Brachycephalic Obstructive Airway Syndrome

The domestic dog may be the most morphologically diverse terrestrial mammalian species known to man; pedigree dogs are artificially selected for extreme aesthetics dictated by formal Breed Standards, and breed-related disorders linked to conformation are ubiquitous and diverse. Brachycephaly–foreshortening of the facial skeleton–is a discrete mutation that has been selected for in many popular dog breeds e.g. the Bulldog, Pug, and French Bulldog. A chronic, debilitating respiratory syndrome, whereby soft tissue blocks the airways, predominantly affects dogs with this conformation, and thus is labelled Brachycephalic Obstructive Airway Syndrome (BOAS). Despite the name of the syndrome, scientific evidence quantitatively linking brachycephaly with BOAS is lacking, but it could aid efforts to select for healthier conformations. Here we show, in (1) an exploratory study of 700 dogs of diverse breeds and conformations, and (2) a confirmatory study of 154 brachycephalic dogs, that BOAS risk increases sharply in a non-linear manner as relative muzzle length shortens. BOAS only occurred in dogs whose muzzles comprised less than half their cranial lengths. Thicker neck girths also increased BOAS risk in both populations: a risk factor for human sleep apnoea and not previously realised in dogs; and obesity was found to further increase BOAS risk. This study provides evidence that breeding for brachycephaly leads to an increased risk of BOAS in dogs, with risk increasing as the morphology becomes more exaggerated. As such, dog breeders and buyers should be aware of this risk when selecting dogs, and breeding organisations should actively discourage exaggeration of this high-risk conformation in breed standards and the show ring

Genetic influences on cost-efficient organization of human cortical functional networks

The human cerebral cortex is a complex network of functionally specialized regions interconnected by axonal fibers, but the organizational principles underlying cortical connectivity remain unknown. Here, we report evidence that one such principle for functional cortical networks involves finding a balance between maximizing communication efficiency and minimizing connection cost, referred to as optimization of network cost-efficiency. We measured spontaneous fluctuations of the blood oxygenation level-dependent signal using functional magnetic resonance imaging in healthy monozygotic (16 pairs) and dizygotic (13 pairs) twins and characterized cost-efficient properties of brain network functional connectivity between 1041 distinct cortical regions. At the global network level, 60% of the interindividual variance in cost-efficiency of cortical functional networks was attributable to additive genetic effects. Regionally, significant genetic effects were observed throughout the cortex in a largely bilateral pattern, including bilateral posterior cingulate and medial prefrontal cortices, dorsolateral prefrontal and superior parietal cortices, and lateral temporal and inferomedial occipital regions. Genetic effects were stronger for cost-efficiency than for other metrics considered, and were more clearly significant in functional networks operating in the 0.09–0.18 Hz frequency interval than at higher or lower frequencies. These findings are consistent with the hypothesis that brain networks evolved to satisfy competitive selection criteria of maximizing efficiency and minimizing cost, and that optimization of network cost-efficiency represents an important principle for the brain's functional organization

Social group behaviour of triads. Dependence on purpose and gender

We analysed a set of uninstructed pedestrian trajectories automatically tracked in a public area, and we asked a human coder to assess their group relationships. For those pedestrians who belong to the groups, we asked the coder to identify their apparent purpose of visit to the tracking area and apparent gender. We studied the quantitative dependence of the group dynamics on such properties in the case of triads (three people groups) and compared them to the two pedestrian group case (dyads), studied in a previous work. We found that the group velocity strongly depends on relation and gender for both triads and dyads, while the influence of these properties on spatial structure of groups is less clear in the triadic case. We discussed the relevance of these results to the modelling of pedestrian and crowd dynamics, and examined the possibility of the future works on this subject

Intrinsic group behaviour II: On the dependence of triad spatial dynamics on social and personal features; and on the effect of social interaction on small group dynamics

In a follow-up to our work on the dependence of walking dyad dynamics on intrinsic properties of the group, we now analyse how these properties affect groups of three people (triads), taking also in consideration the effect of social interaction on the dynamical properties of the group. We show that there is a strong parallel between triads and dyads. Work-oriented groups are faster and walk at a larger distance between them than leisure-oriented ones, while the latter move in a less ordered way. Such differences are present also when colleagues are contrasted with friends and families; nevertheless the similarity between friend and colleague behaviour is greater than the one between family and colleague behaviour. Male triads walk faster than triads including females, males keep a larger distance than females, and same gender groups are more ordered than mixed ones. Groups including tall people walk faster, while those with elderly or children walk at a slower pace. Groups including children move in a less ordered fashion. Results concerning relation and gender are particularly strong, and we investigated whether they hold also when other properties are kept fixed. While this is clearly true for relation, patterns relating gender often resulted to be diminished. For instance, the velocity difference due to gender is reduced if we compare only triads in the colleague relation. The effects on group dynamics due to intrinsic properties are present regardless of social interaction, but socially interacting groups are found to walk in a more ordered way. This has an opposite effect on the space occupied by non-interacting dyads and triads, since loss of structure makes dyads larger, but causes triads to lose their characteristic V formation and walk in a line (i.e., occupying more space in the direction of movement but less space in the orthogonal one)

Quantifying the Microvascular Origin of BOLD-fMRI from First Principles with Two-Photon Microscopy and an Oxygen-Sensitive Nanoprobe

The blood oxygenation level-dependent (BOLD) contrast is widely used in functional magnetic resonance imaging (fMRI) studies aimed at investigating neuronal activity. However, the BOLD signal reflects changes in blood volume and oxygenation rather than neuronal activity per se. Therefore, understanding the transformation of microscopic vascular behavior into macroscopic BOLD signals is at the foundation of physiologically informed noninvasive neuroimaging. Here, we use oxygen-sensitive two-photon microscopy to measure the BOLD-relevant microvascular physiology occurring within a typical rodent fMRI voxel and predict the BOLD signal from first principles using those measurements. The predictive power of the approach is illustrated by quantifying variations in the BOLD signal induced by the morphological folding of the human cortex. This framework is then used to quantify the contribution of individual vascular compartments and other factors to the BOLD signal for different magnet strengths and pulse sequences.National Institutes of Health (U.S.) (Grant P41RR14075)National Institutes of Health (U.S.) (Grant R01NS067050)National Institutes of Health (U.S.) (Grant R01NS057198)National Institutes of Health (U.S.) (Grant R01EB000790)American Heart Association (Grant 11SDG7600037)Advanced Multimodal NeuroImaging Training Program (R90DA023427

Estimating social relation from trajectories

This study focuses on social pedestrian groups in public spaces and makes an effort to identify the social relation between the group members. We particularly consider dyads having coalitional or mating relation. We derive several observables from individual and group trajectories, which are suggested to be distinctive for these two sorts of relations and propose a recognition algorithm taking these observables as features and yielding an estimation of social relation in a probabilistic manner at every sampling step. On the average, we detect coalitional relation with 87% and mating relation with 81% accuracy. To the best of our knowledge, this is the first study to infer social relation from joint (loco)motion patterns and we consider the detection rates to be a satisfactory considering the inherent challenge of the problem

Macroscopic and microscopic dynamics of a pedestrian cross-flow: Part I, experimental analysis

In this work we investigate the behaviour of a human crowd in a cross-flow by analysing the results of a set of controlled experiments in which subjects were divided into two groups, organised in such a way to explore different density settings, and asked to walk through the crossing area. We study the results of the experiment by defining and investigating a few macroscopic and microscopic observables. Along with analysing traditional indicators such as density and velocity, whose dynamics was, to the extent of our knowledge, poorly understood for this setting, we pay particular attention to walking and body orientation, studying how these microscopic observables are influenced by density. Furthermore, we report a preliminary but quantitative analysis on the emergence of self-organising patterns (stripes) in the crossing area, a phenomenon that had been previously qualitatively reported for human crowds, and reproduced in models, but whose quantitative analysis with respect to density conditions is, again according to our knowledge, a novel contribution

Identification of social relation within pedestrian dyads

This study focuses on social pedestrian groups in public spaces and makes an effort to identify the type of social relation between the group members. As a first step for this identification problem, we focus on dyads (i.e. 2 people groups). Moreover, as a mutually exclusive categorization of social relations, we consider the domain-based approach of Bugental, which precisely corresponds to social relations of colleagues, couples, friends and families, and identify each dyad with one of those relations. For this purpose, we use anonymized trajectory data and derive a set of observables thereof, namely, inter-personal distance, group velocity, velocity difference and height difference. Subsequently, we use the probability density functions (pdf) of these observables as a tool to understand the nature of the relation between pedestrians. To that end, we propose different ways of using the pdfs. Namely, we introduce a probabilistic Bayesian approach and contrast it to a functional metric one and evaluate the performance of both methods with appropriate assessment measures. This study stands out as the first attempt to automatically recognize social relation between pedestrian groups. Additionally, in doing that it uses completely anonymous data and proves that social relation is still possible to recognize with a good accuracy without invading privacy. In particular, our findings indicate that significant recognition rates can be attained for certain categories and with certain methods. Specifically, we show that a very good recognition rate is achieved in distinguishing colleagues from leisure-oriented dyads (families, couples and friends), whereas the distinction between the leisure-oriented dyads results to be inherently harder, but still possible at reasonable rates, in particular if families are restricted to parent-child groups. In general, we establish that the Bayesian method outperforms the functional metric one due, probably, to the difficulty of the latter to learn observable pdfs from individual trajectories