Efficacy and safety of secukinumab administration by autoinjector in patients with psoriatic arthritis: results from a randomized, placebo-controlled trial (FUTURE 3)

Background: The study aimed to assess 52-week efficacy and safety of secukinumab self-administration by autoinjector in patients with active psoriatic arthritis (PsA) in the FUTURE 3 study (ClinicalTrials.gov NCT01989468). Methods: Patients (≥ 18 years of age; N = 414) with active PsA were randomized 1:1:1 to subcutaneous (s.c.) secukinumab 300 mg, 150 mg, or placebo at baseline, weeks 1, 2, 3, and 4, and every 4 weeks thereafter. Per clinical response, placebo-treated patients were re-randomized to s.c. secukinumab 300 or 150 mg at week 16 (nonresponders) or week 24 (responders) and stratified at randomization by prior anti-tumor necrosis factor (TNF) therapy (anti-TNF-naïve, 68.1%; intolerant/inadequate response (anti-TNF-IR), 31.9%). The primary endpoint was the proportion of patients achieving at least 20% improvement in American College of Rheumatology response criteria (ACR20) at week 24. Autoinjector usability was evaluated by Self-Injection Assessment Questionnaire (SIAQ). Results: Overall, 92.1% (300 mg), 91.3% (150 mg), and 93.4% (placebo) of patients completed 24 weeks, and 84.9% (300 mg) and 79.7% (150 mg) completed 52 weeks. In the overall population (combined anti-TNF-naïve and anti-TNF-IR), ACR20 response rate at week 24 was significantly higher in secukinumab groups (300 mg, 48.2% (p < 0.0001); 150 mg, 42% (p < 0.0001); placebo, 16.1%) and was sustained through 52 weeks. SIAQ results showed that more than 93% of patients were satisfied/very satisfied with autoinjector usage. Secukinumab was well tolerated with no new or unexpected safety signals reported. Conclusions: Secukinumab provided sustained improvements in signs and symptoms in active PsA patients through 52 weeks. High acceptability of autoinjector was observed. The safety profile was consistent with that reported previously

Wigner's DD-matrix elements for SU(3)SU(3) - A Generating Function Approach

A generating function for the Wigner's $D$-matrix elements of $SU(3)$ is derived. From this an explicit expression for the individual matrix elements is obtained in a closed form.Comment: RevTex 3.0, 22 pages, no figure

Fire analysis of steel frames with the use of artificial neural networks

The paper presents an alternative approach to the modelling of the mechanical behaviour of steel frame material when exposed to the high temperatures expected in fires. Based on a series of stress-strain curves obtained experimentally for various temperature levels, an artificial neural network (ANN) is employed in the material modelling of steel. Geometrically and materially, a non-linear analysis of plane frame structures subjected to fire is performed by FEM. The numerical results of a simply supported beam are compared with our measurements, and show a good agreement, although the temperature-displacement curves exhibit rather irregular shapes. It can be concluded that ANN is an efficient tool for modelling the material properties of steel frames in fire engineering design studies. (c) 2007 Elsevier Ltd. All rights reserved

Chern-Simons theory and three-dimensional surfaces

There are two natural Chern-Simons theories associated with the embedding of a three-dimensional surface in Euclidean space; one is constructed using the induced metric connection -- it involves only the intrinsic geometry, the other is extrinsic and uses the connection associated with the gauging of normal rotations. As such, the two theories appear to describe very different aspects of the surface geometry. Remarkably, at a classical level, they are equivalent. In particular, it will be shown that their stress tensors differ only by a null contribution. Their Euler-Lagrange equations provide identical constraints on the normal curvature. A new identity for the Cotton tensor is associated with the triviality of the Chern-Simons theory for embedded hypersurfaces implied by this equivalence. The corresponding null surface stress capturing this information will be constructed explicitly.Comment: 10 pages, unnecessary details removed, typos fixed, references adde

Models for Light-Cone Meson Distribution Amplitudes

Leading-twist distribution amplitudes (DAs) of light mesons like pi,rho etc. describe the leading nonperturbative hadronic contributions to exclusive QCD reactions at large energy transfer, for instance electromagnetic form factors. They also enter B decay amplitudes described in QCD factorisation, in particular nonleptonic two-body decays. Being nonperturbative quantities, DAs cannot be calculated from first principles, but have to be described by models. Most models for DAs rely on a fixed order conformal expansion, which is strictly valid for large factorisation scales, but not always sufficient in phenomenological applications. We derive models for DAs that are valid to all orders in the conformal expansion and characterised by a small number of parameters which are related to experimental observables.Comment: 19 pages, 10 figure

Ground State Properties of an Asymmetric Hubbard Model for Unbalanced Ultracold Fermionic Quantum Gases

In order to describe unbalanced ultracold fermionic quantum gases on optical lattices in a harmonic trap, we investigate an attractive ($U<0$) asymmetric ($t_\uparrow\neq t_\downarrow$) Hubbard model with a Zeeman-like magnetic field. In view of the model's spatial inhomogeneity, we focus in this paper on the solution at Hartree-Fock level. The Hartree-Fock Hamiltonian is diagonalized with particular emphasis on superfluid phases. For the special case of spin-independent hopping we analytically determine the number of solutions of the resulting self-consistency equations and the nature of the possible ground states at weak coupling. Numerical results for unbalanced Fermi-mixtures are presented within the local density approximation. In particular, we find a fascinating shell structure, involving normal and superfluid phases. For the general case of spin-dependent hopping we calculate the density of states and the possible superfluid phases in the ground state. In particular, we find a new magnetized superfluid phase.Comment: 9 pages, 5 figure

Evaluación genética en etapa de vivero de áreas productoras de semillas (APS) de Pino Ponderosa en Nordpatagonia

El Pino Ponderosa (Pinus ponderosa Dougl. ex Laws) es la principal especie forestal implantada en secanoen la Patagonia. Su potencialidad productiva y la disponibilidad de tierras para su cultivo permiten proyectarla continuidad de su uso en plantaciones comerciales, para lo que es indispensable asegurar la provisión desemillas de adecuada calidad genética. Las semillas utilizadas en la última década se produjeron en una seriede rodales mediante ensayos para evaluar su descendencia. El objetivo del presente trabajo es evaluar estosrodales ensayando su descendencia. En este primer reporte presentamos los resultados de una evaluaciónen etapa de vivero. Se ensayaron 31 procedencias locales seleccionadas (Áreas Productoras de Semillas,APS) en dos sitios, midiendo altura y diámetro a la altura del cuello en plantines de 2 años de edad. A través de análisis de la varianza se probó un claro efecto de interacción entre las APS y los sitios, y también diferencias entre las APS dentro de cada sitio. Seguidamente, se establecieron rankings de las APS por sitio y variable evaluada. A través de comparaciones de a pares se formaron grupos homogéneos. También se estimó la estabilidad genotípica de las APS por medio del cálculo de sus ecovalencias. Los resultados son aún preliminares, pero el haber probado diferencias en tan temprana edad nos alerta sobre la importancia de la procedencia de las semillas a utilizar para la producción comercial. Se espera que estas diferencias se acentúen en edades más avanzadas. Para probarlo, ya se han establecido ensayos de plantación

Creating Ioffe-Pritchard micro-traps from permanent magnetic film with in-plane magnetization

We present designs for Ioffe-Pritchard type magnetic traps using planar patterns of hard magnetic material. Two samples with different pattern designs were produced by spark erosion of 40 $\mu$m thick FePt foil. The pattern on the first sample yields calculated axial and radial trap frequencies of 51 Hz and 6.8 kHz, respectively. For the second sample the calculated frequencies are 34 Hz and 11 kHz. The structures were used successfully as a magneto-optical trap for $^{87}$Rb and loaded as a magnetic trap. A third design, based on lithographically patterned 250 nm thick FePt film on a Si substrate, yields an array of 19 traps with calculated axial and radial trap frequencies of 1.5 kHz and 110 kHz, respectively.Comment: 8 pages, 5 figures Revised and accepted for EPJD, improved picture

Casimir effect due to a single boundary as a manifestation of the Weyl problem

The Casimir self-energy of a boundary is ultraviolet-divergent. In many cases the divergences can be eliminated by methods such as zeta-function regularization or through physical arguments (ultraviolet transparency of the boundary would provide a cutoff). Using the example of a massless scalar field theory with a single Dirichlet boundary we explore the relationship between such approaches, with the goal of better understanding the origin of the divergences. We are guided by the insight due to Dowker and Kennedy (1978) and Deutsch and Candelas (1979), that the divergences represent measurable effects that can be interpreted with the aid of the theory of the asymptotic distribution of eigenvalues of the Laplacian discussed by Weyl. In many cases the Casimir self-energy is the sum of cutoff-dependent (Weyl) terms having geometrical origin, and an "intrinsic" term that is independent of the cutoff. The Weyl terms make a measurable contribution to the physical situation even when regularization methods succeed in isolating the intrinsic part. Regularization methods fail when the Weyl terms and intrinsic parts of the Casimir effect cannot be clearly separated. Specifically, we demonstrate that the Casimir self-energy of a smooth boundary in two dimensions is a sum of two Weyl terms (exhibiting quadratic and logarithmic cutoff dependence), a geometrical term that is independent of cutoff, and a non-geometrical intrinsic term. As by-products we resolve the puzzle of the divergent Casimir force on a ring and correct the sign of the coefficient of linear tension of the Dirichlet line predicted in earlier treatments.Comment: 13 pages, 1 figure, minor changes to the text, extra references added, version to be published in J. Phys.