59 research outputs found
Modeling of Ti-W Solidification Microstructures Under Additive Manufacturing Conditions
Additive manufacturing (AM) processes have many benefits for the fabrication of alloy parts, including the potential for greater microstructural control and targeted properties than traditional metallurgy processes. To accelerate utilization of this process to produce such parts, an effective computational modeling approach to identify the relationships between material and process parameters, microstructure, and part properties is essential. Development of such a model requires accounting for the many factors in play during this process, including laser absorption, material addition and melting, fluid flow, various modes of heat transport, and solidification. In this paper, we start with a more modest goal, to create a multiscale model for a specific AM process, Laser Engineered Net Shaping (LENS™), which couples a continuum-level description of a simplified beam melting problem (coupling heat absorption, heat transport, and fluid flow) with a Lattice Boltzmann-cellular automata (LB-CA) microscale model of combined fluid flow, solute transport, and solidification. We apply this model to a binary Ti-5.5 wt pct W alloy and compare calculated quantities, such as dendrite arm spacing, with experimental results reported in a companion paper
The Simons Observatory: science goals and forecasts for the enhanced Large Aperture Telescope
We describe updated scientific goals for the wide-field, millimeter-wave survey that will be produced by the Simons Observatory (SO). Significant upgrades to the 6-meter SO Large Aperture Telescope (LAT) are expected to be complete by 2028, and will include a doubled mapping speed with 30,000 new detectors and an automated data reduction pipeline. In addition, a new photovoltaic array will supply most of the observatory's power. The LAT survey will cover about 60% of the sky at a regular observing cadence, with five times the angular resolution and ten times the map depth of the Planck satellite. The science goals are to: (1) determine the physical conditions in the early universe and constrain the existence of new light particles; (2) measure the integrated distribution of mass, electron pressure, and electron momentum in the late-time universe, and, in combination with optical surveys, determine the neutrino mass and the effects of dark energy via tomographic measurements of the growth of structure at redshifts z ≲ 3; (3) measure the distribution of electron density and pressure around galaxy groups and clusters, and calibrate the effects of energy input from galaxy formation on the surrounding environment; (4) produce a sample of more than 30,000 galaxy clusters, and more than 100,000 extragalactic millimeter sources, including regularly sampled AGN light-curves, to study these sources and their emission physics; (5) measure the polarized emission from magnetically aligned dust grains in our Galaxy, to study the properties of dust and the role of magnetic fields in star formation; (6) constrain asteroid regoliths, search for Trans-Neptunian Objects, and either detect or eliminate large portions of the phase space in the search for Planet 9; and (7) provide a powerful new window into the transient universe on time scales of minutes to years, concurrent with observations from the Vera C. Rubin Observatory of overlapping sky
319 BASELINE CHARACTERISTICS AND THE INCIDENCE OF AUTO-IMMUNE HEMOLYTIC ANEMIA IN MYELODYSPLASTIC SYNDROME (MDS) PATIENTS
Endogenous interleukin 6 production protects against histopathologic damage in a murine model of ischemia/reperfusion injury
Burden of comorbidity in patients with advanced NASH-a retrospective analysis using a large US insurance claims database
PGI6 ECONOMIC BURDEN OF PROGRESSION TO CIRRHOSIS IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS (NASH) IN THE UNITED STATES
DNA microarray analysis reveals variable immune and neuroendocrine gene expression in chronically inflamed ganglionic bowel of Hirschsprung’s disease
Intestinal production of IL-6 initiates systemic inflammation in a murine model of intestinal ischemia reperfusion 1 1The Society of Black Academic Surgeons expresses its appreciation to Dr. Walter Pories and the editorial staff of Current Surgery for their interest in the Society and the publication of these abstracts.
Endogenous interleukin 10 does not protect against local or systemic injury in a murine model of intestinal ischemia and reperfusion 1 1The Society of Black Academic Surgeons expresses its appreciation to Dr. Walter Pories and the editorial staff of Current Surgery for their interest in the Society and the publication of these abstracts.
Intestinal expression of interleukin 6 after intestinal ischemia and reperfusion injury: A primary mediator of multi-system organ failure?
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