Measurements of absolute, SI-traceable lunar irradiance with the airborne lunar spectral irradiance (air-LUSI) instrument

The airborne lunar spectral irradiance (air-LUSI) instrument is designed to make low uncertainty measurements of the lunar spectral irradiance from an ER-2 aircraft from altitudes above 95% of the atmosphere. Measurements cover the visible and near infrared spectral region (350 nm to 1050 nm) and are traceable to the international system of units. Five demonstration flights were conducted in November 2019 at NASA's Armstrong Flight Research Center. During that campaign, air-LUSI measured the spectral irradiance at lunar phase angles ranging from 10° to 60°. This work provides an overview of the air-LUSI instrument, the lunar irradiance measurements made during demonstration flights, a description of our calibration approach, and summary of the uncertainty budget. Based on the flight results and laboratory measurements, we estimate the instrument is capable of measuring lunar irradiance, propagated to the top-of-the atmosphere, with combined standard uncertainty of 1% (k = 1) or less over the spectral region from 450 nm to 980 nm. An examination of the uncertainty budget leads to a path forward toward potentially achieving uncertainties of 0.6% in lunar irradiance over much of the spectral range for future flights

The irradiance instrument subsystem (IRIS) on the airborne-lunar spectral irradiance (air-LUSI) instrument

The objective of the airborne lunar spectral irradiance (air-LUSI) project is to make low uncertainty, SI-traceable measurements of the LUSI in the visible to near-infrared region from an aircraft above most of the optically absorbing components of the atmosphere. The measurements are made from a NASA ER-2 aircraft, which can fly at altitudes of approximately 20 km above sea level. Air-LUSI measurements, corrected for residual atmospheric attenuation, are designed to provide a matrix of low uncertainty top-of-the-atmosphere lunar irradiances at known lunar phase and libration angles to be compared and combined with other lunar irradiance data sets to constrain the uncertainties in models of lunar irradiance and reflectance. The measurements are also expected to provide insight into the differences between models and satellite sensor measurements of lunar irradiance. This paper describes the development and characterization of the air-LUSI subsystem for acquiring lunar measurements, called the irradiance instrument subsystem, prior to flight

Alterations in cognitive performance during passive hyperthermia are task dependent

The objectives of this study were to (1) assess the effect of passive heating upon attention and memory task performance, and (2) evaluate the effectiveness of the application of cold packs to the head on preserving these functions. Using a counterbalance design 16 subjects underwent three trials: a control (CON, 20°C, 40% rH), hot (HOT, 50°C, 50% rH) and hot with the head kept cool (HHC). In each condition, three attention tests and two memory tests were performed. Mean core, forehead and tympanic temperatures were all significantly higher (p< 0.05) during HOT (38.6° ±0.1°, 39.6° ±0.2° and 38.8°±0.1°C, respectively) and HHC (38°±0.2, 37.7°±0.3° and 37.7°C, respectively) than in CON (37.1°±0.6°, 33.3° ±0.2° and 35.9°±0.3°C, respectively). Results indicate that there was impairment in working memory with heat exposure (p < 0.05) without alteration in attentional processes. The regular application of cold packs only prevented the detrimental effect of hyperthermia on short-term memory. Our results show that impairments in cognitive function with passive hyperthermia and the beneficial effect of head cooling are task dependent and suggests that exposure to a hot environment is a competing variable to the cognitive processes

Mapping the Risk of Anaemia in Preschool-Age Children: The Contribution of Malnutrition, Malaria, and Helminth Infections in West Africa

Ricardo Soares Magalhães and colleagues used national cross-sectional household-based demographic health surveys to map the distribution of anemia risk in preschool children in Burkina Faso, Ghana, and Mali

Path to Facilitate the Prediction of Functional Amino Acid Substitutions in Red Blood Cell Disorders – A Computational Approach

A major area of effort in current genomics is to distinguish mutations that are functionally neutral from those that contribute to disease. Single Nucleotide Polymorphisms (SNPs) are amino acid substitutions that currently account for approximately half of the known gene lesions responsible for human inherited diseases. As a result, the prediction of non-synonymous SNPs (nsSNPs) that affect protein functions and relate to disease is an important task.In this study, we performed a comprehensive analysis of deleterious SNPs at both functional and structural level in the respective genes associated with red blood cell metabolism disorders using bioinformatics tools. We analyzed the variants in Glucose-6-phosphate dehydrogenase (G6PD) and isoforms of Pyruvate Kinase (PKLR & PKM2) genes responsible for major red blood cell disorders. Deleterious nsSNPs were categorized based on empirical rule and support vector machine based methods to predict the impact on protein functions. Furthermore, we modeled mutant proteins and compared them with the native protein for evaluation of protein structure stability.We argue here that bioinformatics tools can play an important role in addressing the complexity of the underlying genetic basis of Red Blood Cell disorders. Based on our investigation, we report here the potential candidate SNPs, for future studies in human Red Blood Cell disorders. Current study also demonstrates the presence of other deleterious mutations and also endorses with in vivo experimental studies. Our approach will present the application of computational tools in understanding functional variation from the perspective of structure, expression, evolution and phenotype