Two-machine flowshop scheduling with conditional deteriorating second operations

2005-2006 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Johnson's rule, composite jobs and the relocation problem

2008-2009 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Two-machine flowshop batching and scheduling

Author name used in this publication: T. C. E. Cheng2004-2005 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Scheduling in an assembly-type production chain with batch transfer

Author name used in this publication: T. C. E. Cheng2006-2007 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Single machine scheduling to minimize batch delivery and job earliness penalties

Version of RecordPublishe

Dorsal hippocampal involvement in conditioned-response timing and maintenance of temporal information in the absence of the CS

Involvement of the dorsal hippocampus (DHPC) in conditioned-response timing and maintaining temporal information across time gaps was examined in an appetitive Pavlovian conditioning task, in which rats with sham and DHPC lesions were first conditioned to a 15-s visual cue. After acquisition, the subjects received a series of non-reinforced test trials, on which the visual cue was extended (45 s) and gaps of different duration, 0.5, 2.5, and 7.5 s, interrupted the early portion of the cue. Dorsal hippocampal-lesioned subjects underestimated the target duration of 15 s and showed broader response distributions than the control subjects on the no-gap trials in the first few blocks of test, but the accuracy and precision of their timing reached the level of that of the control subjects by the last block. On the gap trials, the DHPC-lesioned subjects showed greater rightward shifts in response distributions than the control subjects. We discussed these lesion effects in terms of temporal versus non-temporal processing (response inhibition, generalisation decrement, and inhibitory conditioning)

Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation

[[abstract]]Although polychlorinated biphenyls (PCBs) have been shown to accumulate in the adrenal, little is known about the effects of these endocrine disruptors on adrenal steroidogenesis. Our previous studies showed that high concentrations of PCB126 stimulated CYP11B1 and CYP11B2 mRNA expression and consequently raised cortisol and aldosterone synthesis in the human adrenocortical H295R cells, respectively. In this study, we further investigated the mechanism underlying the PCB126-induced steroidogenic alterations. We first examined the role of the PCB126 nuclear receptor aryl hydrocarbon receptor (AhR) using a potent antagonist 3',4'-dimethoxyflavone (3',4'-DMF). Although 3',4'-DMF abolished AhR-dependent transcriptional activity, it could not block PCB126-stimulated CYP11B1 and CYP11B2 induction. Conversely, 3',4'-DMF synergistically increased the stimulatory effects of PCB126. Furthermore, PCB39, -77, -132, -156, and -169, whether AhR ligands or not, all could increase CYP11B1 and CYP11B2 mRNA accumulation. Promoter analyses demonstrated that PCB126 had little effects on the transcription rate of both genes, whereas RNA degradation assays showed that PCB126 protected both transcripts from degradation. In contrast, 3',4'-DMF exhibited positive effects on transcription but no influence on transcript stability. The synergistic induction of CYP11B1 and CYP11B2 mRNA levels by the PCB126/3',4'-DMF cotreatment might result from the combination of transcriptional regulation by 3',4'-DMF and posttranscriptional regulation by PCB126. This study also demonstrated that an internal region of CYP11B1 mRNA (nucleotides 881-1285) was important for PCB126-mediated transcript stabilization. From these findings, we concluded that PCB126 up-regulated steroidogenic CYP11B1 and CYP11B2 mRNA expression not via AhR-mediated transcriptional activation but by increasing posttranscriptional mRNA stability

Two-agent integrated scheduling of production and distribution operations with fixed departure times

202208_bcwwVersion of RecordOthersThe Hong Kong Polytechnic UniversityPublishedAIMS (2022