Does severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study

Objective To compare the time course of organ dysfunction/failure, mortality and cause of death in patients with severe sepsis (SS) and patients with severe non-infectious systemic inflammatory response syndrome (SNISIRS). Design Secondary analysis of a multi-centre inception cohort study. Setting Twenty-three multidisciplinary intensive care units (ICUs) in Australia and New Zealand. Patients and participants 3,543 ICU admissions ≥48 h o