239 research outputs found
Insights into How HIAs are Characterized in the Press: Findings from a Media Analysis of Widely Circulated United States Newspapers
Background: Health impact assessments (HIAs) are burgeoning tools in the policy arena, where media plays an important role by focusing attention on issues, informing the public, and influencing positions. Examining how media portrays HIAs is critical to understanding HIAs in the policy context. Methods: This study considered how widely circulated, U.S. newspapers represent HIAs. After searching newspaper databases, we used a qualitative document analysis method consisting of open and axial coding to examine specific phrases of HIA depictions. Results: In coding over 1,000 unique phrases from the 62 documents generated in our search, we found an uptick in HIA-related publications since 2010. Coding these documents identified 46 distinct codes across 10 different themes. The two most prominent HIA-centered themes focused on HIA engagement and the HIA setting. While themes of policy and science, health determinants, and explanations of HIAs were also frequently featured, specific mentions of projected impacts, HIA processes, HIA values, and health outcomes were less prevalent. Conclusion: HIA media portrayals warrant further inquiry by researchers and practitioners. Focusing on how media portrays HIAs is consistent with several HIA steps. It is also important for a broader strategy to educate stakeholders about HIAs and to understand HIAs’ utility. HIA practitioners should develop and implement guidelines for media interaction and tracking that encourage practitioners to seek additional media attention and to focus such attention on health impacts and outcomes, HIA recommendations, and HIA values. Building on our work, researchers should examine HIA media portrayals beyond the context of this study
New Active Asteroid 313P/Gibbs
We present initial observations of the newly-discovered active asteroid
313P/Gibbs (formerly P/2014 S4), taken to characterize its nucleus and
comet-like activity. The central object has a radius 0.5 km (geometric
albedo 0.05 assumed). We find no evidence for secondary nuclei and set (with
qualifications) an upper limit to the radii of such objects near 25 m, assuming
the same albedo. Both aperture photometry and a morphological analysis of the
ejected dust show that mass-loss is continuous at rates 0.2 to 0.4 kg
s, inconsistent with an impact origin. Large dust particles, with radii
50 to 100 m, dominate the optical appearance. At 2.4 AU from the
Sun, the surface equilibrium temperatures are too low for thermal or
desiccation stresses to be responsible for the ejection of dust. No gas is
spectroscopically detected (limiting the gas mass loss rate to 1.8 kg
s). However, the protracted emission of dust seen in our data and the
detection of another episode of dust release near perihelion, in archival
observations from 2003, are highly suggestive of an origin by the sublimation
of ice. Coincidentally, the orbit of 313P/Gibbs is similar to those of several
active asteroids independently suspected to be ice sublimators, including
P/2012 T1, 238P/Read and 133P/Elst-Pizarro, suggesting that ice is abundant in
the outer asteroid belt.Comment: 24 pages, 7 figures, accepted The Astronomical Journa
A Comet Active Beyond the Crystallization Zone
We present observations showing in-bound long-period comet C/2017 K2
(PANSTARRS) to be active at record heliocentric distance. Nucleus temperatures
are too low (60 K to 70 K) either for water ice to sublimate or for amorphous
ice to crystallize, requiring another source for the observed activity. Using
the Hubble Space Telescope we find a sharply-bounded, circularly symmetric dust
coma 10 km in radius, with a total scattering cross section of 10
km. The coma has a logarithmic surface brightness gradient -1 over much of
its surface, indicating sustained, steady-state dust production. A lack of
clear evidence for the action of solar radiation pressure suggests that the
dust particles are large, with a mean size 0.1 mm. Using a coma
convolution model, we find a limit to the apparent magnitude of the nucleus 25.2 (absolute magnitude 12.9). With assumed geometric albedo =
0.04, the limit to the nucleus circular equivalent radius is 9 km.
Pre-discovery observations from 2013 show that the comet was also active at
23.7 AU heliocentric distance. While neither water ice sublimation nor
exothermic crystallization can account for the observed distant activity, the
measured properties are consistent with activity driven by sublimating
supervolatile ices such as CO, CO, O and N. Survival of
supervolatiles at the nucleus surface is likely a result of the comet's recent
arrival from the frigid Oort cloud.Comment: 20 pages, 3 figures, 2 tables, published on Astrophysical Journal
Letters, 847:L19 (5pp), 2017 October
Coma Anisotropy and the Rotation Pole of Interstellar Comet 2I/Borisov
Hubble Space Telescope observations of interstellar comet 2I/Borisov near
perihelion show the ejection of large (>~100 um) particles at <~9 m/s speeds,
with estimated mass-loss rates of ~35 kg/s. The total mass loss from comet
Borisov corresponds to loss of a surface shell on the nucleus only ~0.4 m
thick. This shell is thin enough to be susceptible to past chemical processing
in the interstellar medium by cosmic rays, meaning that the ejected materials
cannot necessarily be considered as pristine. Our high-resolution images reveal
persistent asymmetry in the dust coma, best explained by a thermal lag on the
rotating nucleus causing peak mass loss to occur in the comet nucleus
afternoon. In this interpretation, the nucleus rotates with an obliquity of 30
deg (pole direction RA = 205 deg and Dec. = 52 deg). The subsolar latitude
varied from -35 deg (southern solstice) at the time of discovery to 0 deg
(equinox) in 2020 January, suggesting the importance of seasonal effects.
Subsequent activity likely results from regions freshly activated as the
northern hemisphere is illuminated for the first time.Comment: 8 pages, 7 figure
Fragmentation Kinematics in Comet 332P/Ikeya-Murakami
We present initial time-resolved observations of the split comet
332P/Ikeya-Murakami taken using the Hubble Space Telescope. Our images reveal a
dust-bathed cluster of fragments receding from their parent nucleus at
projected speeds in the range 0.06 to 3.5 m s from which we estimate
ejection times from October to December 2015. The number of fragments with
effective radii 20 m follows a differential power law with index
= -3.60.6, while smaller fragments are less abundant than
expected from an extrapolation of this power-law. We argue that, in addition to
losses due to observational selection, torques from anisotropic outgassing are
capable of destroying the small fragments by driving them quickly to rotational
instability. Specifically, the spin-up times of fragments 20 m in
radius are shorter than the time elapsed since ejection from the parent
nucleus. The effective radius of the parent nucleus is 275 m
(geometric albedo 0.04 assumed). This is about seven times smaller than
previous estimates and results in a nucleus mass at least 300 times smaller
than previously thought. The mass in solid pieces, kg, is about
4% of the mass of the parent nucleus. As a result of its small size, the parent
nucleus also has a short spin-up time. Brightness variations in time-resolved
nucleus photometry are consistent with rotational instability playing a role in
the release of fragments.Comment: 19 pages, 1 table, 4 figures, To be published on ApJ
Outburst and Splitting of Interstellar Comet 2I/Borisov
We present Hubble Space Telescope observations of a photometric outburst and
splitting event in interstellar comet 2I/Borisov. The outburst, first reported
with the comet outbound at 2.8 AU (Drahus et al.~2020), was caused by the
expulsion of solid particles having a combined cross-section about 100 sq. km
and a mass in 0.1 mm sized particles about 2e7 kg. The latter corresponds to
1e-4 of the mass of the nucleus, taken as a sphere of radius 500 m. A transient
``double nucleus'' was observed on UT 2020 March 30 (about three weeks after
the outburst), having a cross-section about 0.6 sq. km and corresponding dust
mass 1e5 kg. The secondary was absent in images taken on and before March 28,
and in images taken on and after April 03. The unexpectedly delayed appearance
and rapid disappearance of the secondary are consistent with an origin through
rotational bursting of one or more large (meter-sized) boulders under the
action of outgassing torques, following their ejection from the main nucleus.
Overall, our observations reveal that the outburst and splitting of the nucleus
are minor events involving a negligible fraction of the total mass: 2I/Borisov
will survive its passage through the planetary region largely unscathed.Comment: 21 pages, 5 figures, 1 appendi
The Nucleus of Interstellar Comet 2I/Borisov
We present high resolution imaging observations of interstellar comet
2I/Borisov (formerly C/2019 Q4) obtained using the Hubble Space Telescope.
Scattering from the comet is dominated by a coma of large particles
(characteristic size 0.1 mm) ejected anisotropically. Convolution modeling of
the coma surface brightness profile sets a robust limit to the
spherical-equivalent nucleus radius r_n < 0.5 km (geometric albedo 0.04
assumed). We obtain an independent constraint based on the non-gravitational
acceleration of the nucleus, finding r_n > 0.2 km (nucleus density 500 kg/m3
assumed). The profile and the non-gravitational constraints cannot be
simultaneously satisfied if density < 25 kg/m3; the nucleus of comet Borisov
cannot be a low density fractal assemblage of the type proposed elsewhere for
the nucleus of 1I/'Oumuamua. We show that the spin-up timescale to outgassing
torques, even at the measured low production rates, is comparable to or shorter
than the residence time in the Sun's water sublimation zone. The spin angular
momentum of the nucleus should be changed significantly during the current
solar fly-by. Lastly, we find that the differential interstellar size
distribution in the 0.5 mm to 100 m size range can be represented by power laws
with indices < 4 and that interstellar bodies of 100 m size scale strike Earth
every one to two hundred million years.Comment: 24 Pages, 5 Figure
Adolescent trajectories of fine motor and coordination skills and risk for schizophrenia
Premorbid motor dysfunction is one of the earliest of developmental antecedents identified among individuals who develop schizophrenia in adulthood. However, among individuals with schizophrenia, premorbid motor dysfunction is not apparent at all stages of childhood development and may reduce with increasing age. Currently, little is known about the trajectories of motor development during adolescence among youth at-risk for the disorder. One hundred and one participants were assessed repeatedly, at approximately 24-month intervals (time 1, aged 9–12 years; time 2, 11–14 years; and time 3, 13–16 years), on the Purdue Pegboard assessment, comprising four subtests: Dominant Hand (DH), Non-Dominant Hand (NDH), Both Hands (BH), and Assembly. Fine motor and coordination skills development between ages 9–16 years was compared between youth characterised by a triad of developmental antecedents of schizophrenia (ASz, N = 32); youth with at least one affected relative with schizophrenia/schizoaffective disorder (FHx; N = 26); and typically developing youth without antecedents or family history (TD, N = 43). Longitudinal mixed models for repeated measures indicated significant motor skills improvements with age in TD youth on the Assembly subtest only. Relative to TD youth, we found evidence for developmental deficits (i.e., dysfunction that emerged early and remained stable) among ASz youth on DH and BH subtests, and among FHx youth on the Assembly subtest. ASz youth were characterised by a developmental delay on the Assembly subtest (i.e., initial performance decrement in middle childhood that caught up with peers’ performance during adolescence). These divergences from normative motor development may reflect differences in structural and functional neural correlates.</p
Neutrophils in cancer: neutral no more
Neutrophils are indispensable antagonists of microbial infection and facilitators of wound healing. In the cancer setting, a newfound appreciation for neutrophils has come into view. The traditionally held belief that neutrophils are inert bystanders is being challenged by the recent literature. Emerging evidence indicates that tumours manipulate neutrophils, sometimes early in their differentiation process, to create diverse phenotypic and functional polarization states able to alter tumour behaviour. In this Review, we discuss the involvement of neutrophils in cancer initiation and progression, and their potential as clinical biomarkers and therapeutic targets
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